Estramustin
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- CAS-Nr.
- 2998-57-4
- Bezeichnung:
- Estramustin
- Englisch Name:
- Estramustine
- Synonyma:
- LEO 275;Estracty;NSC89201;NSC 89201;NSC-89201;Estamustine;Estramustin;ESTRAMUSTINE;Alestramustine;Estramustine USP/EP/BP
- CBNumber:
- CB9127416
- Summenformel:
- C23H31Cl2NO3
- Molgewicht:
- 440.4
- MOL-Datei:
- 2998-57-4.mol
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Estramustin Eigenschaften
- Schmelzpunkt:
- 104-105°
- alpha
- D20 +50° (in dioxane)
- Siedepunkt:
- 565.8±50.0 °C(Predicted)
- Dichte
- 1.253±0.06 g/cm3(Predicted)
- storage temp.
- Store at -20°C
- Aggregatzustand
- Solid
- pka
- 15.05±0.40(Predicted)
- Farbe
- White to off-white
- Wasserlöslichkeit
- 1mg/L(30 ºC)
- CAS Datenbank
- 2998-57-4(CAS DataBase Reference)
Sicherheit
- Risiko- und Sicherheitserklärung
- Gefahreninformationscode (GHS)
| Bildanzeige (GHS) |
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| Alarmwort |
Warnung |
| Gefahrenhinweise |
| Code |
Gefahrenhinweise |
Gefahrenklasse |
Abteilung |
Alarmwort |
Symbol |
P-Code |
| H302 |
Gesundheitsschädlich bei Verschlucken. |
Akute Toxizität oral |
Kategorie 4 |
Warnung |
![GHS hazard pictograms]() src="/GHS07.jpg" width="20" height="20" /> |
P264, P270, P301+P312, P330, P501 |
| H315 |
Verursacht Hautreizungen. |
Hautreizung |
Kategorie 2 |
Warnung |
![GHS hazard pictograms]() src="/GHS07.jpg" width="20" height="20" /> |
P264, P280, P302+P352, P321,P332+P313, P362 |
| H319 |
Verursacht schwere Augenreizung. |
Schwere Augenreizung |
Kategorie 2 |
Warnung |
![GHS hazard pictograms]() src="/GHS07.jpg" width="20" height="20" /> |
P264, P280, P305+P351+P338,P337+P313P |
| H335 |
Kann die Atemwege reizen. |
Spezifische Zielorgan-Toxizität (einmalige Exposition) |
Kategorie 3 (Atemwegsreizung) |
Warnung |
![GHS hazard pictograms]() src="/GHS07.jpg" width="20" height="20" /> |
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| Sicherheit |
| P261 |
Einatmen von Staub vermeiden. |
| P305+P351+P338 |
BEI KONTAKT MIT DEN AUGEN: Einige Minuten lang behutsam mit Wasser spülen. Eventuell vorhandene Kontaktlinsen nach Möglichkeit entfernen. Weiter spülen. |
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Estramustin Chemische Eigenschaften,Einsatz,Produktion Methoden
Verwenden
Antineoplastic.
Definition
ChEBI: A carbamate ester obtained by the formal condensation of the hydroxy group of 17beta-estradiol with the carboxy group of bis(2-chloroethyl)carbamic acid.
Indications
Estramustine phosphate sodium (Emcyt) is a hybrid
structure combining estradiol and a nitrogen mustard in
a single molecule. The drug has been approved for use
in prostatic carcinomas and will produce clinical remissions
in one-third of patients who have failed to respond
to previous estrogen therapy. The mechanism of
action of estramustine is not well defined, but it does
not appear to require either alkylation of DNA or the
presence of estrogen receptors in tumor cells.
Nonetheless, the toxicities of the drug are similar to
those of estrogen therapy: breast tenderness and enlargement
(gynecomastia), fluid retention, mild nausea,
and an increased risk of thrombophlebitis and pulmonary
embolism.The drug is not myelosuppressive.
Biologische Funktion
Estramustine has a low affinity for the βm tubulin isotype, which often is overexpressed in estramustineresistant prostatic neoplasms as one defense against this therapeutic intervention.
Mechanism of action
Because this anticancer agent contains a carbamylated nitrogen mustard moiety, it is most commonly classified as a DNA alkylator; however, it is now known that its primary mechanism of antineoplastic action is inhibition of mitosis.
Estramustin Upstream-Materialien And Downstream Produkte
Upstream-Materialien
Downstream Produkte
Estramustin Anbieter Lieferant Produzent Hersteller Vertrieb Händler.
Global( 90)Lieferanten
2998-57-4(Estramustin)Verwandte Suche:
N,N'-Bis(2-chlorethyl)-nitrosoharnstoff
Methanol
Kresoxim-methyl
Acetonitril
Bendamustine hydrochloride
Basic Violet 1
2-Chlor-N-(2-chlorethyl)-N-methyl-ethanamin-hydrochlorid
Methyl-4-hydroxybenzoat
Paraquat-dichlorid
Chlorambucil
Bendamustine
Estra-1,3,5(10)-trien-3,17α-diol
3,6-Bis[(4-chlor-2-phosphonophenyl)azo]-4,5-dihydroxynaphthalin-2,7-disulfonsure
Methylacrylat
Methyl
Estra-1,3,5(10)-trien-3,17-diol-(17β)-, 3-[Bis(2-chlorethyl)carbamat] 17-(Dihydrogen-phosphat), Dinatriumsalz
Estra-1,3,5(10)-trien-3,17β-diol-3-[bis(2-chloroethyl)carbamat]-17-(dihydrogenphosphat)
Chlormethin
- 3,5(10)-triene-3,17-diol(17beta)-estra-3-(bis(2-chloroethyl)carbamate)
- LEO 275
- 1,3,5(10)-Estratriene-3,17β-diol 3-[bis(2-chloroethyl)carbamate]
- 1,3,5(10)-Estratriene-3,17β-diol 3-[N,N-bis(2-chloroethyl)carbamate]
- Estamustine
- estradiol,3-(bis(2-chloroethyl)carbamate)
- ESTRAMUSTINE
- Estramustin
- Estra-1,3,5(10)-triene-3,17-diol (17b)-, 3-[bis(2-chloroethyl)carbamate]
- Estra-1,3,5(10)-triene-3,17-diol, 3-(bis(2-chloroethyl)carbamate), (17 beta)-
- Alestramustine
- (17-Hydroxy-13-methyl-6,7,8,9,11,12,14,15,16,17-decahydrocyclopenta[a]phenanthren-3-yl) N,N-bis(2-chloroethyl)carbamate
- Estra-1,3,5(10)-triene-3,17-diol (17beta)-, 3-(bis(2-chloroethyl)carbamate)
- Estracty
- Estradiol 3-[N,N-bis(2-chloroethyl)carbamate]
- Estra-1,3,5(10)-triene-3,17-diol (17β)-, 3-[bis(2-chloroethyl)carbamate]
- Estramustine Na USP/EP/BP
- Estramustine USP/EP/BP
- NSC 89201
- NSC89201
- NSC-89201
- Microtubule/Tubulin,Estramustine,inhibit,prostate tumor,Inhibitor,antineoplastic,depolymerization,antimitotic
- 2998-57-4
- C23H31Cl2NO3NaO3P
- C23H31Cl2NO3
