Anti-ER degradation enhancer, mannosidase alpha-like 3 Chemische Eigenschaften,Einsatz,Produktion Methoden
Verwenden
Anti-EDEM3 (C-terminal) antibody produced in rabbit is suitable for immunoprecipitation at a concentration of 1-2μL using mouse 3T3 cell lysates and western blotting (at a dilution of 1:1,000-1:2,000 using whole extract of human HEK-293T cells and at a dilution of 1:500-1:1,000 using whole extrct of rat PC12 cells).
Biochem/physiol Actions
ER degradation-enhancing α-mannosidase-like 3 is an enzyme encoded by the EDEM3 gene in humans and consists of 931 amino acids. It consists of motifs of Class I α-mannosidases (glycosyl hydrolase family 47) in its N-terminal domain and a protease-associated motif in its C-terminal region. EDEM3 has α1,2-mannosidase activity. EDEM3 is also aasociated with folding-incompetent proteins carrying N-glycans that are extracted from futile folding cycles in the calnexin chaperone system.
Anti-ER degradation enhancer, mannosidase alpha-like 3 Upstream-Materialien And Downstream Produkte
Upstream-Materialien
Downstream Produkte
