Entospletinib (GS-9973)

Entospletinib (GS-9973) Struktur
1229208-44-9
CAS-Nr.
1229208-44-9
Englisch Name:
Entospletinib (GS-9973)
Synonyma:
Entospletinib;6-(1H-indazol-6-yl)-N-(4-morpholinophenyl)imidazo[1,2-a]pyrazin-8-amine;GS-9973;CS-1602;GS-9973;GS 9973;GS-9973, Entospletinib;Entospletinib (GS-9973);Entospletinib Dimesylate;GS9973; GS 9973; ENTOSPLETINIB;Entospletinib (GS-9973) USP/EP/BP
CBNumber:
CB92703799
Summenformel:
C23H21N7O
Molgewicht:
411.46
MOL-Datei:
1229208-44-9.mol

Entospletinib (GS-9973) Eigenschaften

Dichte
1.45±0.1 g/cm3(Predicted)
storage temp. 
Desiccate at -20°C
Löslichkeit
insoluble in EtOH; insoluble in H2O; ≥20.55 mg/mL in DMSO
Aggregatzustand
solid
pka
12.54±0.40(Predicted)
Farbe
White to gray

Sicherheit

Entospletinib (GS-9973) Chemische Eigenschaften,Einsatz,Produktion Methoden

Beschreibung

Spleen tyrosine kinase (Syk) is a non-receptor tyrosine kinase that upon phosphorylation binds to immunoreceptor tyrosine-based activation motifs of FcRγ chains and mediates downstream signaling related to platelet function and inflammation. GS-9973 is a potent Syk inhibitor (IC50 = 7.7 nM) that demonstrates 10-35-fold selectivity for Syk over a panel of 359 nonmutant kinases. In conjunction with the PI3Kδ inhibitor CAL-101 , it has been used to reduce chronic lymphocytic leukemia cell survival and to disrupt chemokine signaling at nanomolar concentrations.

Verwenden

GS 9973 is a selective and orally bioavailable inhibitor of spleen tyrosine kinase (Syk).

Entospletinib (GS-9973) Upstream-Materialien And Downstream Produkte

Upstream-Materialien

Downstream Produkte


Entospletinib (GS-9973) Anbieter Lieferant Produzent Hersteller Vertrieb Händler.

Global( 124)Lieferanten
Firmenname Telefon E-Mail Land Produktkatalog Edge Rate
ATK CHEMICAL COMPANY LIMITED
+undefined-21-51877795
ivan@atkchemical.com China 32957 60
Hubei Jusheng Technology Co.,Ltd.
18871490254
linda@hubeijusheng.com CHINA 28172 58
BOC Sciences
+1-631-485-4226
inquiry@bocsci.com United States 19553 58
career henan chemical co
+86-0371-86658258 +8613203830695
factory@coreychem.com China 29811 58
TargetMol Chemicals Inc.
+1-781-999-5354 +1-00000000000
marketing@targetmol.com United States 32165 58
HANGZHOU CLAP TECHNOLOGY CO.,LTD
86-571-88216897,88216896 13588875226
sales@hzclap.com CHINA 6312 58
Dideu Industries Group Limited
+86-29-89586680 +86-15129568250
1026@dideu.com China 22883 58
Zhejiang J&C Biological Technology Co.,Limited
+1-2135480471 +1-2135480471
sales@sarms4muscle.com China 10473 58
InvivoChem
+1-708-310-1919 +1-13798911105
sales@invivochem.cn United States 6391 58
Coresyn Pharmatech Co., Ltd.
+86-571-86626709 +86-18157142896
cbc@coresyn.com China 9984 58

  • GS-9973
  • 6-(1H-Indazol-6-yl)-N-[4-(4-morpholinyl)phenyl]imidazo[1,2-a]pyrazin-8-amine
  • Entospletinib (GS-9973)
  • Entospletinib Dimesylate
  • GS-9973, Entospletinib
  • GS-9973;GS 9973
  • CS-1602
  • GS9973; GS 9973; ENTOSPLETINIB
  • 6-(1H-indazol-6-yl)-N-(4-morpholin-4-ylphenyl)imidazo[1,2-a]pyrazin-8-amine
  • 6-(1H-INDAZOL-6-YL)-N-(4-MORPHOLINOPHENYL)IMIDAZO[1,2-A]PYRAZIN-8-AMINE,GS-9973
  • Imidazo[1,2-a]pyrazin-8-amine, 6-(1H-indazol-6-yl)-N-[4-(4-morpholinyl)phenyl]-
  • Entospletinib (GS-9973) USP/EP/BP
  • Entospletinib
  • 6-(1H-indazol-6-yl)-N-(4-morpholinophenyl)imidazo[1,2-a]pyrazin-8-amine
  • 1229208-44-9
  • Inhibitors
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