ReModelin
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- CAS-Nr.
- 949912-58-7
- Englisch Name:
- ReModelin
- Synonyma:
- CS-2149;ReModelin;Reaxys ID: 18559527;4-[2-(2-Cyclopentylidenehydrazinyl)-4-thiazolyl]benzonitrile;4-(2-(2-Cyclopentylidenehydrazineyl)thiazol-4-yl)benzonitrile;4- (2- (2-cyclopentylidenehydrazine) thiazol-4-yl) benzonitrile;Benzonitrile, 4-[2-(2-cyclopentylidenehydrazinyl)-4-thiazolyl]-;4-[2-(2-Cyclopentylidenehydrazinyl)-4-thiazolyl]-benzonitrile hydrobromide
- CBNumber:
- CB92729373
- Summenformel:
- C15H14N4S
- Molgewicht:
- 282.36
- MOL-Datei:
- 949912-58-7.mol
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ReModelin Eigenschaften
- Siedepunkt:
- 498.9±47.0 °C(Predicted)
- Dichte
- 1.31±0.1 g/cm3(Predicted)
- storage temp.
- 2-8°C
- Löslichkeit
- DMSO: soluble20mg/mL, clear
- Aggregatzustand
- powder
- pka
- 14.40±0.20(Predicted)
- Farbe
- white to beige
- Stabilität:
- Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 3 months.
Sicherheit
- Risiko- und Sicherheitserklärung
- Gefahreninformationscode (GHS)
| Kennzeichnung gefährlicher |
Xn |
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| R-Sätze: |
22 |
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| WGK Germany |
3 |
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| Bildanzeige (GHS) |
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| Alarmwort |
Warnung |
| Gefahrenhinweise |
| Code |
Gefahrenhinweise |
Gefahrenklasse |
Abteilung |
Alarmwort |
Symbol |
P-Code |
| H302 |
Gesundheitsschädlich bei Verschlucken. |
Akute Toxizität oral |
Kategorie 4 |
Warnung |
![GHS hazard pictograms]() src="/GHS07.jpg" width="20" height="20" /> |
P264, P270, P301+P312, P330, P501 |
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| Sicherheit |
| P280 |
Schutzhandschuhe/Schutzkleidung/Augenschutz tragen. |
| P305+P351+P338 |
BEI KONTAKT MIT DEN AUGEN: Einige Minuten lang behutsam mit Wasser spülen. Eventuell vorhandene Kontaktlinsen nach Möglichkeit entfernen. Weiter spülen. |
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ReModelin Chemische Eigenschaften,Einsatz,Produktion Methoden
Beschreibung
Progeria is a genetic disorder that results in the appearance of premature aging. Genetically, progeria is characterized by a mutation in lamin A, which results in misshapen cell nuclei and DNA damage. Remodelin is a 2-thiazolylhydrazone derivative that, at 10 μM, improves nuclear architecture, chromatin organization, and survival of both cells lacking lamin A and cells from patients with progeria. Remodelin is an inhibitor of N-acetyltransferase 10 (NAT10), which acetylates both histones and microtubules. Mutation of NAT10 mimics the effects of remodelin on nuclear morphology, suggesting that these effects of remodelin require NAT10. Remodelin also has cytotoxic effects against some species of the fungus
Candida.
Verwenden
Remodelin improves nuclear architecture, chromatin organization, and fitness of both human lamin A/C-depleted cells and Hutchinson-Gilford progeria syndrome (HGPS)-derived patient cells. N-acetyltransferase 10 (NAT10) inhibitor.
ReModelin Upstream-Materialien And Downstream Produkte
Upstream-Materialien
Downstream Produkte
ReModelin Anbieter Lieferant Produzent Hersteller Vertrieb Händler.
Global( 98)Lieferanten
- ReModelin
- 4-[2-(2-Cyclopentylidenehydrazinyl)-4-thiazolyl]-benzonitrile hydrobromide
- 4-[2-(2-Cyclopentylidenehydrazinyl)-4-thiazolyl]benzonitrile
- CS-2149
- Benzonitrile, 4-[2-(2-cyclopentylidenehydrazinyl)-4-thiazolyl]-
- Reaxys ID: 18559527
- 4-(2-(2-Cyclopentylidenehydrazineyl)thiazol-4-yl)benzonitrile
- 4- (2- (2-cyclopentylidenehydrazine) thiazol-4-yl) benzonitrile
- 949912-58-7
