lumateperone (Tosylate)
|
|
|
- CAS-Nr.
- 1187020-80-9
- Englisch Name:
- lumateperone (Tosylate)
- Synonyma:
- Lumateperone, Caplyta;ITI 007;ITI007 tosylate;ITI722 tosylate;ITI 007 tosylate;ITI 722 tosylate;ITI-007 tosylate;ITI-722 tosylate;Lumateperone(ITI-007);Lumateperone PTSA salt
- CBNumber:
- CB93121116
- Summenformel:
- C31H36FN3O4S
- Molgewicht:
- 565.7
- MOL-Datei:
- 1187020-80-9.mol
|
lumateperone (Tosylate) Eigenschaften
- storage temp.
- Store at -20°C
- Löslichkeit
- DMF: 25 mg/ml; DMF:PBS (pH 7.2) (1:7): 0.12 mg/ml; DMSO: 10 mg/ml; Ethanol: 1 mg/ml
- Aggregatzustand
- A solid
- Farbe
- White to gray
- InChIKey
- LHAPOGAFBLSJJQ-HXLBOWIHNA-N
- SMILES
- S(C1C=CC(C)=CC=1)(O)(=O)=O.CN1CCN2[C@@]3([H])CCN(CCCC(C4C=CC(F)=CC=4)=O)C[C@@]3([H])C3=CC=CC1=C32 |&1:16,34,r|
Sicherheit
- Risiko- und Sicherheitserklärung
- Gefahreninformationscode (GHS)
| Bildanzeige (GHS) |
 
|
| Alarmwort |
Warnung |
| Gefahrenhinweise |
| Code |
Gefahrenhinweise |
Gefahrenklasse |
Abteilung |
Alarmwort |
Symbol |
P-Code |
| H336 |
Kann Schläfrigkeit und Benommenheit verursachen. |
Spezifische Zielorgan-Toxizität (einmalige Exposition) |
Kategorie 3 (Schläfrigkeit und Benommenheit) |
Warnung |
|
P261, P271, P304+P340, P312,P403+P233, P405, P501 |
|
| Sicherheit |
| P202 |
Vor Gebrauch alle Sicherheitshinweise lesen und verstehen. |
| P261 |
Einatmen von Staub vermeiden. |
| P271 |
Nur im Freien oder in gut belüfteten Räumen verwenden. |
| P280 |
Schutzhandschuhe/Schutzkleidung/Augenschutz tragen. |
| P308+P313 |
BEI Exposition oder falls betroffen: Ärztlichen Rat einholen/ärztliche Hilfe hinzuziehen. |
|
lumateperone (Tosylate) Chemische Eigenschaften,Einsatz,Produktion Methoden
Verwenden
lumateperone (Tosylate) is a new second-generation antipsychotic indicated for treating schizophrenia that can potentially alleviate positive and negative symptoms. This drug interacts with dopamine, serotonin, and glutamate, making it unique compared to other antipsychotics. Its highly selective nature for D2R receptors in specific brain regions decreases unfavorable adverse effects and makes it a safer drug[1].
Biochem/physiol Actions
Lumateperone tosylate (ITI-007) is an orally active, potent 5-HT2A antagonist, postsynaptic D2 antagonist, and serotonin transporter SERT inhibitor (Ki = 0.5, 32, 62 nM, respectively) with in vivo antipsychotic efficacy and no effect toward receptors associated with cognitive and metabolic side effects of antipsychotic drugs (e.g., H1, 5-HT2C, muscarinic). ITI-007 blocks DOI-induced headtwitch (ID50 = 0.09 mg/kg, po.) and D-AMPH-induced hyperlocomotion in mice (ID50 = 0.95 mg/kg, po.), while also acting as a partial agonist at presynaptic striatal D2 receptors.
lumateperone (Tosylate) Upstream-Materialien And Downstream Produkte
Upstream-Materialien
Downstream Produkte
lumateperone (Tosylate) Anbieter Lieferant Produzent Hersteller Vertrieb Händler.
Global( 123)Lieferanten
1187020-80-9()Verwandte Suche:
- 1-(4-Fluorophenyl)-4-[(6bR,10aS)-2,3,6b,9,10,10a-hexahydro-3-methyl-1H-pyrido[3',4':4,5]pyrrolo[1,2,3-de]quinoxalin-8(7H)-yl]-1-butanone 4-methylbenzenesulfonate (1:1)
- Lumateperone(ITI-007)
- lumateperone (Tosylate)
- ITI 007
- ITI-007;ITI 007;ITI007;LUMATEPERONE;1187020-80-9
- ITI-722; ITI722; ITI 722; ITI-007; ITI007; ITI 007; LUMATEPERONE, CAPLYTA,
- lumateperone (Tosylate) ISO 9001：2015 REACH
- Lumateperone toluenesulfonic acid (PTSA salt)
- Lumateperone, Caplyta
- Lumateperone PTSA salt
- Dopamine Receptor,ITI007,schizophrenia,lumateperone Tosylate,Inhibitor,inhibit,dopamine D1 receptor,5-HT2A,5-hydroxytryptamine Receptor,presynaptic D2 receptor,5-HT Receptor,Lumateperone,ITI 007,postsynaptic D2 receptor,Serotonin Receptor
- 1-(4-Fluorophenyl)-4-((6bR,10aS)-3-methyl-2,3,6b,7,10,10a-hexahydro-1H-pyrido[3',4':4,5]pyrrolo[1,2,3-de]quinoxalin-8(9H)-yl)butan-1-one 4-methylbenzenesulfonate
- Lumateperone P-toluenesulfonate Salt
- ITI 007 tosylate
- ITI 722 tosylate
- ITI007 tosylate
- ITI-007 tosylate
- ITI722 tosylate
- ITI-722 tosylate
- 1-(4-Fluorophenyl)-4-((6bR,10aS)-3-methyl-2,3,6b,7,10,10a-hexahydro-1H-pyrido[3',4':4,5]pyrrolo[1,2,3-de]quinoxalin-8(9H)-yl)butan-1-one 4-methylbenzenesulfonate
- 1187020-80-9
- C24H28FN3OC7H8O3S
