7,11b-Dihydrobenz[b]indeno[1,2-d]pyran-3,6a,9,10(6H)-tetrol

7,11b-Dihydrobenz[b]indeno[1,2-d]pyran-3,6a,9,10(6H)-tetrol Chemische Eigenschaften,Einsatz,Produktion Methoden

Beschreibung

Brazilin is an isoflavonoid originally isolated from C. sappan that has diverse biological activities, including neuroprotective, anti-inflammatory, antibacterial, and antioxidant properties. Brazilin inhibits Aβ (1-42) fibrillogenesis (IC₅₀ = 1.5 μM) more potently than (-)-epigallocatechin gallate , cucurmin , and resveratrol. It also prevents remodeling of mature Aβ (1-42) fibrils. Brazilin inhibits the production of cytokines, including PGE₂ and TNF-α (IC₅₀s = 12.6 and 87.2 μM). It is effective against Gram-positive and Gram-negative bacteria with MICs ranging from 31.3 to 250 μg/ml. In addition, brazilin inhibits osteoclast differentiation mediated by RANKL and is protective against LPS-induced osteoporosis in mice at a dose of 100 mg/kg.

Brazilin family of natural products.

Verwenden

inhibits platelet aggregation, PLA2, PKC, protein phosphatase, insulin receptor kinase, nitric oxide synthase, antineoplastic

Definition

ChEBI: Brazilin is a tertiary alcohol, a member of catechols and an organic heterotetracyclic compound. It has a role as an antioxidant, a biological pigment, an antibacterial agent, an antineoplastic agent, a hepatoprotective agent, an anti-inflammatory agent, an apoptosis inducer, a NF-kappaB inhibitor, a plant metabolite and a histological dye.

läuterung methode

Brazilin crystallises from EtOH as yellow crystals which become orange when exposed to light and air, and is yellow in dilute acid but crimson in dilute alkali. When crystallised from H2O, it has m 247-248o. It forms coloured metal salts and is oxidized in air to Brazilein the quinonoid form. The (±)-form has been resolved, and the (+)-enantiomer has [] 20 +121o (c 1, MeOH). [Craig et al. J Org Chem 30 1573 1965,Morsingh & Robinson Tetrahedron 26 281 1970, Beilstein 17 H 194, 17 II 244, 17 III/IV 2711.]

7,11b-Dihydrobenz[b]indeno[1,2-d]pyran-3,6a,9,10(6H)-tetrol Upstream-Materialien And Downstream Produkte

Upstream-Materialien

Downstream Produkte

7,11b-Dihydrobenz[b]indeno[1,2-d]pyran-3,6a,9,10(6H)-tetrol Anbieter Lieferant Produzent Hersteller Vertrieb Händler.

Firmenname	Telefon	E-Mail	Land	Produktkatalog	Edge Rate
Chengdu Herbpurify Co.Ltd.	2355253622; 18981954830	2355253622@qq.com;	China	1089	58
Chembest Research Laboratories Limited	021-20908456	sales@BioChemBest.com	China	5996	61
Nanjing Chemlin Chemical Co., Ltd	025-83697070 13770331960	info@chemlin.com.cn	China	15343	64
Shenzhen Sungening Bio-Tech Co., Ltd	+86-0755-89668383	sales@sungening.com	China	1319	65
Dalian Meilun Biotech Co., Ltd.	0411-62910999 13889544652	sales@meilune.com	China	4760	58
BioBioPha Co., Ltd.	0871-65217109	y.liu@mail.biobiopha.com	China	5641	65
ShangHai YuanYe Biotechnology Co., Ltd.	18916372613	shyysw007@163.com	China	4993	60
Chengdu Ai Keda Chemical Technology Co., Ltd.	4008-755-333 18080918076	800078821@qq.com	China	9706	55
Chengdu Biopurify Phytochemicals Ltd.	+86-028-82633397 18982077548	cwb1@biopurify.cn	China	2376	60
Chengdu Climax Biotech Co., Ltd.	028-83311324 1278112614	climaxbiotech@gmail.com	China	925	58

474-07-7(7,11b-Dihydrobenz[b]indeno[1,2-d]pyran-3,6a,9,10(6H)-tetrol)Verwandte Suche:

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• NSC 56652
• 7,11b-dihydroindeno[2,1-c]chromene-3,6a,9,10(6H)-tetrol
• 2-d)pyran-3,6a,9,10(6h)-tetrol,7,11b-dihydro-benz(b)indeno(
• 6a,9,10(6h)-tetrol,7,11b-dihydro-2-d]pyran-(6as-cis)-benz[b]indeno[
• 7,11b-dihydrobenz(b)indeno(1,2-d)pyran-3,6a,9,10(6h)-tetrol
• brasilin
• braziletto
• hypernicextract
• limawoodextract
• pernambucoextract
• BRAZILIN (C.I. 75280)
• CI 75280
• BRAZILIN
• superbresiline
• Benz[b]indeno[1,2-d]pyran-3,6a,9,10(6H)-tetrol,7,11b-dihydro-, (6aS,11bR)-
• Brazilin(6CI)
• enz[b]indeno[1,2-d]pyran-3,6a,9,10(6H)-tetrol,7,11b-dihydro-,(6aS-cis)-(7CI,8CI)
• razilin
• (6aS,11bR)-7,11b-Dihydrobenz[b]indeno[1,2-d]pyran-3,6a,9,10(6H)-tetrol
• Brazilin >=98% (HPLC)
• (+)-Brazilin
• Brazilin, 98%, from Caesalpinia sappanL.
• (6aS,11bR)-6,6a,7,11b-tetrahydroindeno[2,1-c]chromene-3,6a,9,10-tetraol
• (6aS,11bR)-7,11b-Dihydroindeno[2,1-c]chromene-3,6a,9,10(6H)-tetraol
• Brazilin-RM
• Arginine Impurity 3 Hydrochloride (Arginine EP Impurity C Hydrochloride)(Ornithine Hydrochloride)
• Brazilin, 10 mM in DMSO
• Brazilin - Bio-X ?
• (6aS,11bR)-6,6a,7,11b-Tetrahydroindeno[2,1-c]chromen-3,6a,9,10-tetraol
• Brazilin (Standard)
• 474-07-7
• chemical reagent
• pharmaceutical intermediate
• phytochemical
• reference standards from Chinese medicinal herbs (TCM).
• standardized herbal extract