MMP-2 SUBSTRATE, FLUOROGENIC

MMP-2 SUBSTRATE, FLUOROGENIC Struktur
CAS-Nr.
Englisch Name:
MMP-2 SUBSTRATE, FLUOROGENIC
Synonyma:
390 MMP FRET SUBSTRATE III;MCA-PLA-NVA-DAP(DNP)-AR-NH2;MMP-2 SUBSTRATE, FLUOROGENIC;MCA-PRO-LEU-ALA-NVA-DPA-ALA-ARG-NH2;MCA-PRO-LEU-ALA-NVA-DAP(DNP)-ALA-ARG-NH2
CBNumber:
CB9354821
Summenformel:
C50H70N14O15
Molgewicht:
1107.18
MOL-Datei:
Mol file

MMP-2 SUBSTRATE, FLUOROGENIC Eigenschaften

storage temp. 
-20°C

Sicherheit

MMP-2 SUBSTRATE, FLUOROGENIC Chemische Eigenschaften,Einsatz,Produktion Methoden

Verwenden

Matrix metalloproteinases (MMP) are a family of zinc-dependent endopeptidases that degrade matrix proteins. MMPs include collagenases, gelatinases, matrilysins, enamelysins, metalloelastases, stromelysins and other structural protein and receptor lysins. The activity of these enzymes is selectively inhibited or measured by appropriately labeled peptides. MCA-Pro-Leu-Ala-Nva-DNP-Dap-Ala-Arg-NH2; DNP-Pro-Leu-Gly-Met-Trp-Ser-Arg (DNP-PLGMWSR), Dnp-Pro-Leu-Gly-Leu-Trp-Ala-D-Arg-NH2 (DNP-PLGLWA-D-R-NH2), Dnp-Pro-Gln-Gly-Ile-Ala-Gly-Gln-D-Arg-OH (DNP-PQGIAGQ-D-R-OH) and MOCAc [(7-methoxy coumarin-4-yl) acetyl]-RPKPYANvaWMK(Dnp[2,4-dinitrophenyl])-NH(2) are substrates for matrix metalloproteinase 2.

Allgemeine Beschreibung

Matrix metalloproteinases (MMPs) are localized to the nucleus, mitochondria, vesicles and cytoplasm. MMP family comprises of 25 members, of which 24 are present in mammals. MMPs are encoded as inactive enzymes and are localized to cell membranes. All MMP members possess pro domain (80 amino acids) and catalytic domains.

Biochem/physiol Actions

Matrix metalloproteinases (MMPs) are responsible for degrading membrane proteins, such as basal lamina proteins of cerebral blood vessels. Proteolysis of intracellular substrates by MMPs is associated with the innate immune system and apoptosis. They are also involved in disease conditions such as oncogenesis, cardiac, neurological and autoimmune disorders. MMPs are also associated with pathogenesis related to protein conformational changes. Elevated expression of a number of MMPs is observed in myocardial infarction and heart failure.

MMP-2 SUBSTRATE, FLUOROGENIC Upstream-Materialien And Downstream Produkte

Upstream-Materialien

Downstream Produkte


MMP-2 SUBSTRATE, FLUOROGENIC Anbieter Lieferant Produzent Hersteller Vertrieb Händler.

Global( 16)Lieferanten
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GL Biochem (Shanghai) Ltd 21-61263452 13641803416
ymbetter@glbiochem.com China 9981 64
Sigma-Aldrich 021-61415566 800-8193336
orderCN@merckgroup.com China 51471 80
Hangzhou Peptidego Biotech Co.,Ltd. 0571-87213919
eric@peptidego.com China 6526 58
Nanjing Meihao Pharmaceutical Technology Co., Ltd. meitaochem@126.com
meitaochem@126.com China 19105 58
Wuxi Helen Biotechnology Co., Ltd., 0510-85629785 18013409632
sales@reading-chemicals.com China 14092 58
Hangzhou Sinoda Pharmaceutical Technology Co. LTD 0571-87213919 17306812703
3007955328@qq.com China 6213 58
Shanghai Toyang Biotechnology Co., LTD 021-59555769 13524932310
1405894150@qq.com China 8221 58
Wuhan Peptide Core Biotechnology Co., Ltd 027-65317797 13667154760
1096814016@qq.com China 9753 58

  • MCA-PRO-LEU-ALA-NVA-DAP(DNP)-ALA-ARG-NH2
  • MCA-PRO-LEU-ALA-NVA-DPA-ALA-ARG-NH2
  • MCA-PLA-NVA-DAP(DNP)-AR-NH2
  • 390 MMP FRET SUBSTRATE III
  • MMP-2 SUBSTRATE, FLUOROGENIC
  • peptide
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