Gap19

1507930-57-5

CAS-Nr.: 1507930-57-5

Englisch Name:: Gap19

Synonyma:: Gap19;KQIEIKKFK;L-Lysine, L-lysyl-L-glutaminyl-L-isoleucyl-L-α-glutamyl-L-isoleucyl-L-lysyl-L-lysyl-L-phenylalanyl-;myocardial,Gap19,cytoplasmic,Cx40/pannexin-1,inhibit,Gap Junction Protein,C-terminus,Gap 19,hemichannel,Inhibitor,loop,Gap-19,Cx43,channels,connexin;(2S,5S,8S,11S,14S,17S)-17-((2S,3S)-2-((S)-5-Amino-2-((S)-2,6-diaminohexanamido)-5-oxopentanamido)-3-methylpentanamido)-2,8,11-tris(4-aminobutyl)-5-benzyl-14-((S)-sec-butyl)-4,7,10,13,16-pentaoxo-3,6,9,12,15-pentaazaicosane-1,20-dioic acid;(2S,5S,8S,11S,14S,17S)-17-((2S,3S)-2-((S)-5-Amino-2-((S)-2,6-diaminohexanamido)-5-oxopentanamido)-3-methylpentanamido)-2,8,11-tris(4-aminobutyl)-5-benzyl-14-((S)-sec-butyl)-4,7,10,13,16-pentaoxo-3,6,9,12,15-pentaazaicosane-1,20-dioic acid , Gap19

CBNumber:: CB94632530

Summenformel:: C55H96N14O13

Molgewicht:: 1161.46

MOL-Datei:: 1507930-57-5.mol

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Eigenschaften Sicherheit Verwendungswort Produktionsfirma 55

Gap19 Eigenschaften

Siedepunkt:: 1511.4±65.0 °C(Predicted)

Dichte: 1.212±0.06 g/cm3(Predicted)

storage temp.: -20°C

Löslichkeit: ≥58.07 mg/mL in H2O; insoluble in EtOH; ≥26.55 mg/mL in DMSO

Aggregatzustand: powder

pka: 3.30±0.10(Predicted)

Farbe: white to off-white

Wasserlöslichkeit: Soluble to 2 mg/ml in water

Sicherheit

Gap19 Chemische Eigenschaften,Einsatz,Produktion Methoden

Verwenden

Gap19 is a short peptide that inhibits hemichannels specifically for connexin-43 (Cx43), a cardiac connexin involved with gap junction formation. Gap junctions facilitate the exchange of ions and metabolites between cytoplasm and extracellular milieu. Reagents that inhibit hemichannels may have cardioprotective properties.

Biochem/physiol Actions

Gap19, nonapeptide from the cytoplasmic loop of Connexin-43, is a selective blocker of connexin 43 (Cx43) hemichannel that does not block GJ or Cx40/Panx-1 channels in cardiomyocytes and astrocytes. Gap19 prevents Cx43 hemichannel opening and protect against myocardial ischemia/reperfusion injury.

Gap19 Upstream-Materialien And Downstream Produkte

Upstream-Materialien

Downstream Produkte

Gap19 Anbieter Lieferant Produzent Hersteller Vertrieb Händler.

Global( 55)Lieferanten

Firmenname	Telefon	E-Mail	Land	Produktkatalog	Edge Rate
Shenzhen Nexconn Pharmatechs Ltd	+86-755-89396905 +86-15013857715	admin@nexconn.com	China	10310	58
Career Henan Chemica Co	+86-0371-86658258 +8613203830695	laboratory@coreychem.com	China	30240	58
BOC Sciences	16314854226; +16314854226	inquiry@bocsci.com	United States	19741	58
Zhejiang J&C Biological Technology Co.,Limited	+1-2135480471 +1-2135480471	sales@sarms4muscle.com	China	10473	58
TargetMol Chemicals Inc.		support@targetmol.com	United States	38632	58
Nanjing TGpeptide	+86-13347807150 +86-13347807150	support@tgpeptide.com	China	3279	58
Sichuan Jisheng Biopharmaceutical	+86-0833-2598903 +8619981963231	jane@jsjpharm.cn	China	175	58
Aladdin Scientific	+1-+1(833)-552-7181	sales@aladdinsci.com	United States	57505	58
Changsha MOL Changes Biotechnology Co., Ltd.	+8619375158599	info@molchanges.com	China	5225	58
ShangHai Caerulum Pharma Discovery Co., Ltd.	18149758185 18149758185	sales-cpd@caerulumpharma.com	China	3466	58

Gap19
L-Lysine, L-lysyl-L-glutaminyl-L-isoleucyl-L-α-glutamyl-L-isoleucyl-L-lysyl-L-lysyl-L-phenylalanyl-
myocardial,Gap19,cytoplasmic,Cx40/pannexin-1,inhibit,Gap Junction Protein,C-terminus,Gap 19,hemichannel,Inhibitor,loop,Gap-19,Cx43,channels,connexin
KQIEIKKFK
(2S,5S,8S,11S,14S,17S)-17-((2S,3S)-2-((S)-5-Amino-2-((S)-2,6-diaminohexanamido)-5-oxopentanamido)-3-methylpentanamido)-2,8,11-tris(4-aminobutyl)-5-benzyl-14-((S)-sec-butyl)-4,7,10,13,16-pentaoxo-3,6,9,12,15-pentaazaicosane-1,20-dioic acid , Gap19
(2S,5S,8S,11S,14S,17S)-17-((2S,3S)-2-((S)-5-Amino-2-((S)-2,6-diaminohexanamido)-5-oxopentanamido)-3-methylpentanamido)-2,8,11-tris(4-aminobutyl)-5-benzyl-14-((S)-sec-butyl)-4,7,10,13,16-pentaoxo-3,6,9,12,15-pentaazaicosane-1,20-dioic acid
1507930-57-5
C55H96N14O13