Lysine-specific Demethylase Inhibitor (1C) Chemische Eigenschaften,Einsatz,Produktion Methoden
Allgemeine Beschreibung
A bisguanidine polyamine analogue that exhibits noncompetitive and specific LSD1 inhibition, with 14.1% remaining LSD1 activity at 10 μM
in vitro, and is shown to significantly increase methylation at the histone 3 lysine 4 chromatin mark (H3K4me1 and H3K4me2) dose-dependently from 0.25 μM to 10 μM, without affecting global H3K9me2 (which is not a LSD1 substrate) levels in HCT116 human colon carcinoma cells. This compound induces reexpression of several epigenetically silenced genes including
SFRP1,
SFRP4,
SFRP5, and
GATA5 more effectively when compared with siRNA treatment, particularly in the case of
SFRP4 and
SFRP5.
Lysine-specific Demethylase Inhibitor (1C) Upstream-Materialien And Downstream Produkte
Upstream-Materialien
Downstream Produkte
