PD 173074
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- CAS-Nr.
- 219580-11-7
- Englisch Name:
- PD 173074
- Synonyma:
- CS-458;PD176074;PD-0173074;PD173074, >=98%;PD173074/PD-173074;PD 173074, Free Base;Cholest-5-en-3-ol,(9α)-;PD-173074 FGFR1 FGFR3 inhibitor ab141117;FGF/VEGF Receptor Tyrosine Kinase Inhibitor;FGF/VEGF Receptor Tyrosine Kinase Inhibitor, PD173074
- CBNumber:
- CB9497090
- Summenformel:
- C28H41N7O3
- Molgewicht:
- 523.67
- MOL-Datei:
- 219580-11-7.mol
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PD 173074 Eigenschaften
- Schmelzpunkt:
- 82-85°C
- Dichte
- 1.163
- storage temp.
- 2-8°C
- Löslichkeit
- DMSO: 21 mg/mL
- Aggregatzustand
- solid
- pka
- 10.12±0.43(Predicted)
- Farbe
- yellow
- Stabilität:
- Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20° for up to 3 months.
PD 173074 Chemische Eigenschaften,Einsatz,Produktion Methoden
R-Sätze Betriebsanweisung:
R36/37/38:Reizt die Augen, die Atmungsorgane und die Haut.
S-Sätze Betriebsanweisung:
S26:Bei Berührung mit den Augen sofort gründlich mit Wasser abspülen und Arzt konsultieren.
Chemische Eigenschaften
Yellow Solid
Verwenden
PD 173074
ar signal-related kinase phosphorylation.
Definition
ChEBI: A member of the class of ureas that is 1-tert-butylurea in which one of the hydrogens attached to N3 is substituted by a pyrido[2,3-d]pyrimidin-7-yl group, which is itself substituted at pos
tions 2 and 6 by a 4-(diethylamino)butyl]amino group and a 3,5-dimethoxyphenyl group, respectively. It is a FGF/VEGF receptor tyrosine kinase inhibitor.
Biologische Aktivität
Selective FGFR1 and FGFR3 inhibitor (IC 50 values are 5, 21.5, ~100, 17600 and 19800 nM for FGFR3, FGFR1, VEGFR2, PDGFR and c-Src respectively, and > 50000 nM for EGFR, InsR, MEK and PKC). Inhibits VEGF- and FGF-induced angiogenesis in the mouse cornea model of angiogenesis. Inhibits proliferation and differentiation of oligodendrocyte progenitors.
PD 173074 Upstream-Materialien And Downstream Produkte
Upstream-Materialien
Downstream Produkte
PD 173074 Anbieter Lieferant Produzent Hersteller Vertrieb Händler.
Global( 165)Lieferanten
- n-[2-[[4-(diethylamino)butyl]amino-6-(3,5-dimethoxyphenyl)pyrido[2,3-d]pyrimidin-7-yl]-n'-(1,1-dimethylethyl)urea
- N-[2-[[4-(diethylaMino)butyl]aMino]-6-(3,5-diMethoxyphenyl)pyrido[2,3-d ]pyriMidin-7-yl]-N'-(1,1-diMethylethyl)-
- PD173074/PD-173074
- 1-(tert-butyl)-3-(2-((4-(diethylaMino)butyl)aMino)-6-(3,5-diMethoxyphenyl)pyrido[2,3-d]pyriMidin-7-yl)urea
- 1-(tert-Butyl)-3-(2-((4-(diethylamino)butyl)amino)-6-(3,5-dimethoxyphenyl)pyrido[2,3-d]pyrimidin-
- Urea, N-[2-[[4-(diethylaMino)butyl]aMino]-6-(3,5-diMethoxyphenyl)pyrido[2,3-d]pyriMidin-7-yl]-N'-(1,1-diMethylethyl)-
- PD176074
- N-[2-[[4-(Diethylamino)butyl]amino]-6-(3,5-dimethoxyphenyl)pyrido[2,3-d]pyrimidin-7-yl]-N'-(1,1-dimethylethyl)urea PD 173074
- PD 173074
N-[2-[[4-(Diethylamino)butyl]amino]-6-(3,5-dimethoxyphenyl)pyrido[2,3-d]pyrimidin-7-yl]-N'-(1,1-dimethylethyl)urea
- PD-0173074
- 1-(tert-Butyl)-3-(2-((4-(diethylamino)butyl)amino)-6-(3,5-dimethoxyphenyl)pyrido[2,3-d]pyrimid
- FGF/VEGF Receptor Tyrosine Kinase Inhibitor, PD173074
- PD 173074, Free Base
- PD173074, >=98%
- CS-458
- FGF/VEGF Receptor Tyrosine Kinase Inhibitor, PD173074 - CAS 219580-11-7 - Calbiochem
- FGF/VEGF Receptor Tyrosine Kinase Inhibitor
- PD 173074;PD-173074;FGF/VEGF RECEPTOR TYROSINE KINASE INHIBITOR
- 1-(tert-Butyl)-3-[7-[[4-(diethylamino)butyl]amino]-3-(3,5-dimethoxyphenyl)pyrido[2,3-d]pyrimidin-2-yl]urea
- Cholest-5-en-3-ol,(9α)-
- PD-173074 FGFR1 FGFR3 inhibitor ab141117
- Inhibitor,Fibroblast growth factor receptor,PD173074,Apoptosis,Vascular endothelial growth factor receptor,inhibit,PD 173074,FGFR,PD-173074,VEGFR
- N-[2-[[4-(diethylamino)butyl]amino-6-(3,5-dimethoxyphenyl)pyrido[2,3-d]pyrimidin-7-yl]-N'-(1,1-dimethylethyl)urea
- 219580-11-7
- C28H41N7O3
- Antineoplastic
- API
- Aromatics
- Bases & Related Reagents
- Heterocycles
- Inhibitors
- Intermediates & Fine Chemicals
- Nucleotides
- Pharmaceuticals
