4-(Diphenylmethylen)-1,1-dimethyl-piperidinium-methyl-sulfat
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- CAS-Nr.
- 62-97-5
- Bezeichnung:
- 4-(Diphenylmethylen)-1,1-dimethyl-piperidinium-methyl-sulfat
- Englisch Name:
- Diphemanil Methylsulfate
- Synonyma:
- prantal;variton;Talpran;demotil;nivelona;diphemanil;diphenatil;vagophemanil;diphenmethanil;Diphemanil mesylate
- CBNumber:
- CB9505795
- Summenformel:
- C20H24N.CH3O4S
- Molgewicht:
- 389.51
- MOL-Datei:
- 62-97-5.mol
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4-(Diphenylmethylen)-1,1-dimethyl-piperidinium-methyl-sulfat Eigenschaften
- Schmelzpunkt:
- 194-195℃
- storage temp.
- Inert atmosphere,Store in freezer, under -20°C
- Wasserlöslichkeit
- Soluble in water
- Löslichkeit
- : 16.67 mg/mL (42.80 mM; Need ultrasonic)
- Aggregatzustand
- powder to crystal
- Farbe
- White to Almost white
- Stabilität:
- Hygroscopic
Sicherheit
- Risiko- und Sicherheitserklärung
- Gefahreninformationscode (GHS)
HS Code |
2933.39.4100 |
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Toxizität |
LD50 in rats, mice, guinea pigs (mg/kg): 1107, 64, 404 orally (Margolin) |
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Bildanzeige (GHS) |
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Alarmwort |
Warnung |
Gefahrenhinweise |
Code |
Gefahrenhinweise |
Gefahrenklasse |
Abteilung |
Alarmwort |
Symbol |
P-Code |
H302 |
Gesundheitsschädlich bei Verschlucken. |
Akute Toxizität oral |
Kategorie 4 |
Warnung |
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P264, P270, P301+P312, P330, P501 |
H315 |
Verursacht Hautreizungen. |
Hautreizung |
Kategorie 2 |
Warnung |
src="/GHS07.jpg" width="20" height="20" /> |
P264, P280, P302+P352, P321,P332+P313, P362 |
H319 |
Verursacht schwere Augenreizung. |
Schwere Augenreizung |
Kategorie 2 |
Warnung |
src="/GHS07.jpg" width="20" height="20" /> |
P264, P280, P305+P351+P338,P337+P313P |
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Sicherheit |
P264 |
Nach Gebrauch gründlich waschen. |
P264 |
Nach Gebrauch gründlich waschen. |
P270 |
Bei Gebrauch nicht essen, trinken oder rauchen. |
P280 |
Schutzhandschuhe/Schutzkleidung/Augenschutz tragen. |
P302+P352 |
BEI BERÜHRUNG MIT DER HAUT: Mit viel Wasser/... (Hersteller kann, falls zweckmäßig, ein Reinigungsmittel angeben oder, wenn Wasser eindeutig ungeeignet ist, ein alternatives Mittel empfehlen) waschen. |
P305+P351+P338 |
BEI KONTAKT MIT DEN AUGEN: Einige Minuten lang behutsam mit Wasser spülen. Eventuell vorhandene Kontaktlinsen nach Möglichkeit entfernen. Weiter spülen. |
P332+P313 |
Bei Hautreizung: Ärztlichen Rat einholen/ärztliche Hilfe hinzuziehen. |
P337+P313 |
Bei anhaltender Augenreizung: Ärztlichen Rat einholen/ärztliche Hilfe hinzuziehen. |
P501 |
Inhalt/Behälter ... (Entsorgungsvorschriften vom Hersteller anzugeben) zuführen. |
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4-(Diphenylmethylen)-1,1-dimethyl-piperidinium-methyl-sulfat Chemische Eigenschaften,Einsatz,Produktion Methoden
Beschreibung
Diphemanil is a quaternary ammonium anticholinergic agent. It induces relaxation of isolated guinea pig trachea strips precontracted with methacholine (EC
50 = 0.12 nM). Diphemanil reverses increases in lung resistance and decreases in dynamic lung compliance induced by the non-selective acetylcholine receptor agonist carbachol (carbamoylcholine; ) in vagotomized cats (ED
50s = 17.5 and 19.3 μg/kg, respectively). It reduces salivation induced by the muscarinic acetylcholine receptor agonist pilocarpine in mice when administered subcutaneously at doses ranging from 1.25 to 10 mg/kg.
Verwenden
Bronchodilatator;Anticholinergic
Definition
ChEBI: The alkene resulting from the formal Wittig olefination of benzophenone and 1,1-dimethyl-4-bromopiperidinium methylsulfate. A quaternary ammonium anticholinergic, it binds muscarinic acetycholine receptors and thereby decreases secretory excretion of stoma
h acids, saliva and sweat, It is used topically in the treatment of hyperhidorsis (excessive sweating).
Allgemeine Beschreibung
Diphemanil methylsulfate,4-(diphenylmethylene)-1,1-dimethylpiperidiniummethylsulfate (Prantal), or diphemanil methylsulfate is apotent cholinergic blocking agent. In the usual dosagerange, it acts as an effective parasympatholytic by blockingnerve impulses at the parasympathetic ganglia, but it doesnot invoke a sympathetic ganglionic blockade. It is claimedto be highly specific in its action on those innervations thatactivate gastric secretion and GI motility. Although thisdrug can produce atropine-like side effects, they rarelyoccur at recommended doses. The highly specific nature ofits action on gastric functions makes the drug useful inthe treatment of peptic ulcer, and its lack of atropine-likeeffects makes its use much less distressing than other antispasmodicdrugs. In addition to its action in decreasinggastric hypermotility, diphemanil methylsulfate is valuablein hyperhidrosis in low doses (50 mg twice daily) or topically.The drug is not well absorbed from the GI tract,particularly in the presence of food, and should be administeredbetween meals. The methylsulfate salt was chosen asthe best, because the chloride is hygroscopic and the bromideand iodide ions have exhibited toxic manifestations inclinical use.
4-(Diphenylmethylen)-1,1-dimethyl-piperidinium-methyl-sulfat Upstream-Materialien And Downstream Produkte
Upstream-Materialien
Downstream Produkte
4-(Diphenylmethylen)-1,1-dimethyl-piperidinium-methyl-sulfat Anbieter Lieferant Produzent Hersteller Vertrieb Händler.
Global( 96)Lieferanten
62-97-5(4-(Diphenylmethylen)-1,1-dimethyl-piperidinium-methyl-sulfat)Verwandte Suche:
- nivelona
- p-(alpha-phenylbenzylidene)-1,1-dimethylpiperidiniummethylsulfate
- prantal
- prantalmethylsulfate
- vagophemanil
- vagophemanilmethylsulfate
- variton
- DIPHEMANIL METHYLSULFATE (500 MG) DISCON-TINUED
- 4-(diphenylmethylene)-1,1-dimethyl-piperidiniumethylsulfate
- n,n-dimethyl-4-piperidylidene-1,1-diphenylmethanemethylsulfate
- Diphemanil mesylate
- diphemanil metilsulfate
- Diphenmanil methosulfate
- Talpran
- 4-benzhydrylidene-1,1-dimethyl-piperidin-1-ium
- 4-benzhydrylidene-1,1-dimethylpiperidin-1-ium
- Piperidinium, 4-(diphenylmethylene)-1,1-dimethyl-, methyl sulfate
- Piperidinium, 4-(diphenylmethylene)-1,1-dimethyl-, methyl sulfate (1:1)
- 4-(diphenylmethylene)-1,1-dimethylpiperidiniummethylsulfate
- demotil
- diphemanil
- diphemanilmethylsulfate
- diphenatil
- diphenmanilmethylsulfate
- diphenmethanil
- diphenmethanilmethylsulfate
- DIPHEMANIL METHYLSULFAT
- 4-(Diphenylmethylene)-1,1-dimethylpiperidin-1-ium Methyl Sulfate
- Diphemanil Methylsulfate USP/EP/BP
- iphemanilmethylsulfate
- 62-97-5
- 62-97-6
- C20H24NCH3O4S
- Other APIs