ZK 200775
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- CAS-Nr.
- 161605-73-8
- Englisch Name:
- ZK 200775
- Synonyma:
- MPQX;Fanapanel;ZK 200775;Fanapanel(ZK200775);MPQX;ZK200775;ZK-200775;7-Morpholino-2,3-dioxo-6-(trifluoromethyl)-1,2,3,4-tetrahydroquinoxalin-1-ylmethylphosphonic acid;((7-morpholino-2,3-dioxo-6-(trifluoromethyl)-3,4-dihydroquinoxalin-1(2H)-yl)methyl)phosphonic acid;[[3,4-Dihydro-7-(4-morpholinyl)-2,3-dioxo-6-(trifluoromethyl)-1(2H)-quinoxalinyl]methyl]phosphonicacid;[[3,4-DIHYDRO-7-(4-MORPHOLINYL)-2,3-DIOXO-6-(TRIFLUOROMETHYL)-1(2H)-QUINOXALINYL]METHYL]PHOSPHONIC ACID;P-[[3,4-Dihydro-7-(4-morpholinyl)-2,3-dioxo-6-(trifluoromethyl)-1(2H)-quinoxalinyl]methyl]phosphonic acid
- CBNumber:
- CB9848467
- Summenformel:
- C14H15F3N3O6P
- Molgewicht:
- 409.25
- MOL-Datei:
- 161605-73-8.mol
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ZK 200775 Eigenschaften
- Dichte
- 1.615±0.06 g/cm3(Predicted)
- storage temp.
- Inert atmosphere,2-8°C
- Löslichkeit
- DMSO: ≥20mg/mL
- pka
- 2.09±0.10(Predicted)
- Aggregatzustand
- powder
- Farbe
- off-white to light brown
ZK 200775 Chemische Eigenschaften,Einsatz,Produktion Methoden
Verwenden
ZK 200775 is a competitive AMPA/kainate antagonist. Neuronal protection against cerebral ischemia.
Biologische Aktivität
Competitive AMPA/kainate antagonist. In rat cortical membranes, displays high affinity for [ 3 H]-AMPA (K i = 120 nM) and [ 3 H]-CNQX (K i = 32 nM) binding sites and low affinity for kainate and NMDA channel-associated binding sites (IC 50 values range from 2.5 to 11 μ M). Inhibits currents induced by AMPA, kainate and NMDA with IC 50 values of 21 nM, 27 nM, and > 1 μ M respectively. Displays anxiolytic, anticonvulsant and muscle relaxant activity in vivo .
ZK 200775 Upstream-Materialien And Downstream Produkte
Upstream-Materialien
Downstream Produkte
ZK 200775 Anbieter Lieferant Produzent Hersteller Vertrieb Händler.
Global( 53)Lieferanten
- ZK 200775
- [[3,4-Dihydro-7-(4-morpholinyl)-2,3-dioxo-6-(trifluoromethyl)-1(2H)-quinoxalinyl]methyl]phosphonicacid
- Fanapanel
- MPQX
- 7-Morpholino-2,3-dioxo-6-(trifluoromethyl)-1,2,3,4-tetrahydroquinoxalin-1-ylmethylphosphonic acid
- [[3,4-Dihydro-7-(4-morpholinyl)-2,3-dioxo-6-(trifluoromethyl)-1(2H)-quinoxalinyl]methyl]-phosphonic acid hydrate
- P-[[3,4-Dihydro-7-(4-morpholinyl)-2,3-dioxo-6-(trifluoromethyl)-1(2H)-quinoxalinyl]methyl]phosphonic acid
- [[3,4-DIHYDRO-7-(4-MORPHOLINYL)-2,3-DIOXO-6-(TRIFLUOROMETHYL)-1(2H)-QUINOXALINYL]METHYL]PHOSPHONIC ACID
- Phosphonic acid, P-[[3,4-dihydro-7-(4-morpholinyl)-2,3-dioxo-6-(trifluoromethyl)-1(2H)-quinoxalinyl]methyl]-
- MPQX;ZK200775;ZK-200775
- Fanapanel(ZK200775)
- ((7-morpholino-2,3-dioxo-6-(trifluoromethyl)-3,4-dihydroquinoxalin-1(2H)-yl)methyl)phosphonic acid
- 161605-73-8
- C14H15F3N3O6P
- C14H15N3O6F3P
