Piperacillin Sodium | 59703-84-3

Piperacillin Sodium Properties

Melting point	183-185 C (dec.)
Boiling point	793℃
refractive index	180 ° (C=0.8, H2O)
storage temp.	Inert atmosphere,2-8°C
solubility	H₂O: 50 mg/mL, clear, colorless to faintly yellow
form	Solid
color	White to Almost white
Water Solubility	Soluble in ethanol, water and methanol.
Merck	14,7463
BRN	5373920
Stability	Hygroscopic
InChIKey	WCMIIGXFCMNQDS-IDYPWDAWSA-M
CAS DataBase Reference	59703-84-3(CAS DataBase Reference)
FDA UNII	M98T69Q7HP

SAFETY

Risk and Safety Statements

Symbol(GHS)	GHS08
Signal word	Warning
Hazard statements	H317-H334
Precautionary statements	P261-P280g-P284-P304+P340-P342+P311a-P501a
Hazard Codes	Xn
Risk Statements	42/43
Safety Statements	22-36/37-45
WGK Germany	2
RTECS	XI0180000
HS Code	29411099
Toxicity	LD50 in mice, rats, dogs, monkeys (g/kg): 5, 2.7, >6, >4 i.v. (Takai)

Piperacillin Sodium price More Price(32)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
Sigma-Aldrich	P8396	Piperacillin sodium salt penicillin analog	59703-84-3	1g	$106	2024-03-01	Buy
Sigma-Aldrich	P8396	Piperacillin sodium salt penicillin analog	59703-84-3	5g	$428	2024-03-01	Buy
TCI Chemical	P1774	Piperacillin Sodium Salt >98.0%(N)	59703-84-3	1g	$88	2024-03-01	Buy
TCI Chemical	P1774	Piperacillin Sodium Salt >98.0%(N)	59703-84-3	5g	$321	2023-06-20	Buy
Alfa Aesar	J66419	Piperacillin sodium salt, 835-1007μg/mg	59703-84-3	1g	$80.65	2024-03-01	Buy

Product number	Packaging	Price	Buy
P8396	1g	$106	Buy
P8396	5g	$428	Buy
P1774	1g	$88	Buy
P1774	5g	$321	Buy
J66419	1g	$80.65	Buy

Piperacillin Sodium Chemical Properties,Uses,Production

Description

Piperacillin sodium is a new beta-lactam antibiotic developed in 1977 by Ueo et al. at Toyama Chemical Company Ltd of Japan. It is licensed and marketed by Lederle Laboratories as Pipracil in the United States. The chemical name of piperacillin sodium is sodium [2S-[2α, 5α, 6β(S*)]]-6-[[[[(4-ethyl-2,3-dioxo1 -piperazinyl) carbonyll-amino] phenylacetyl] amino] -3,3-dimethyl-7-oxo-4-thia- 1 -azabicyclo[3.2.0]heptane-2-carboxylate. It was originally referred to as T1220. Piperacillin is an acylampicillin derivative and is similar in many respects to the previously marketed carboxypenicillins carbenicillin and ticarcillin, the two new ureidopenicillins mezlocillin and azlocillin, and the third-generation cephalosporin (-like) agents cefotaxime, moxalactam, and cefoperazone (the latter is not yet marketed and is structurally similar to piperacillin)[1].

Chemical Properties

When reconstituted, piperacillin sodium is a white to off-white hydroscopic cryodesiccated crystalline that gives a colorless to pale yellow solution. The empirical formula is C23H26N5NaO7S (1.85 mEq or 42.55 mg sodium per gram). One gram of piperacillin is soluble in 1.4 ml of water at 23°C, and the pH of the aqueous solution is 5.5-7.0.

Indications

Piperacillin has been approved for patients with severe infection caused by susceptible strains of specific organisms in the intra-abdominal, urinary tract, gynecologic, lower respiratory tract, skin and skin structure, bone and joint, gonococcal infections, and septicemia. As with other penicillins, piperacillin has a low frequency of toxicity.

benefits

Piperacillin sodium is a beta-lactam antibiotic with a broad range of antibacterial activity that includes gram-negative bacilli, gram-positive cocci (except penicillinase-producing S. aureus), and anaerobic pathogens such as Clostridium difficile, and Bacteroides fragilis. Piperacillin inhibits many of the members of the Enterobacteriaceae, including Klebsiella sp and Pseudomonas, at lower concentrations than required for carbenicillin and ticarcillin.

Metabolism

Piperacillin sodium is administered by intramuscular and intravenous injection and is widely distributed throughout body fluids and tissues. Like other newer penicillins, piperacillin is excreted by both renal and biliary mechanisms. The primary route of elimination is by glomerular filtration, which results in high urinary concentrations of the unchanged compound.

References

[1] C L Fortner, S C Schimpff, R S Finley. “Piperacillin sodium: antibacterial spectrum, pharmacokinetics, clinical efficacy, and adverse reactions.” Pharmacotherapy 2 6 (1982): 287–99.

Piperacillin Sodium Preparation Products And Raw materials

Raw materials

Preparation Products

Piperacillin Sodium Suppliers

Global( 312)Suppliers

Supplier	Tel	Email	Country	ProdList	Advantage
Hebei Mojin Biotechnology Co., Ltd	+8613288715578	sales@hbmojin.com	China	12459	58
Sinoway Industrial co., ltd.	0592-5800732; +8613806035118	xie@china-sinoway.com	China	990	58
Hangzhou ICH Biofarm Co., Ltd	+86-0571-28186870; +undefined8613073685410	sales@ichemie.com	China	985	58
Shaanxi Haibo Biotechnology Co., Ltd	+undefined18602966907	qinhe02@xaltbio.com	China	1000	58
Ouhuang Engineering Materials (Hubei) Co., Ltd	+86-86177	admin@hbouhuang.com	China	2952	58
career henan chemical co	+86-0371-86658258 +8613203830695	sales@coreychem.com	China	29897	58
Hubei Jusheng Technology Co.,Ltd.	18871490254	linda@hubeijusheng.com	CHINA	28180	58
Hebei Guanlang Biotechnology Co., Ltd.	+86-19930503282	alice@crovellbio.com	China	8826	58
Xiamen AmoyChem Co., Ltd	+86-592-6051114 +8618959220845	sales@amoychem.com	China	6387	58
HubeiwidelychemicaltechnologyCo.,Ltd	18627774460	faith@widelychemical.com	CHINA	742	58

Supplier	Advantage
Hebei Mojin Biotechnology Co., Ltd	58
Sinoway Industrial co., ltd.	58
Hangzhou ICH Biofarm Co., Ltd	58
Shaanxi Haibo Biotechnology Co., Ltd	58
Ouhuang Engineering Materials (Hubei) Co., Ltd	58
career henan chemical co	58
Hubei Jusheng Technology Co.,Ltd.	58
Hebei Guanlang Biotechnology Co., Ltd.	58
Xiamen AmoyChem Co., Ltd	58
HubeiwidelychemicaltechnologyCo.,Ltd	58

View Lastest Price from Piperacillin Sodium manufacturers

Image	Update time	Product	Price	Min. Order	Purity	Supply Ability	Manufacturer
	2023-08-21	Sodium tetraborate pentahydrate 12179-04-3		1kg	99%	100tons	Anhui Ruihan Technology Co., Ltd

Sodium tetraborate pentahydrate
12179-04-3
99%
Anhui Ruihan Technology Co., Ltd

Piperacillin sodium salt Spectrum

Piperacillin sodium salt(59703-84-3)¹HNMR

59703-84-3(Piperacillin Sodium)Related Search:

ISOXADIFEN-ETHYL Ethylparaben Ethyl acetate Selenium dioxide N-Aminoethylpiperazine

Sodium gluconate 1,4-Dioxane Sodium hydroxide Diclofenac sodium 2-Ethylhexyl ferulate

Sodium formate Ethanol Sodium bicarbonate Piperacillin Ethyl acrylate

Sodium acetate Sodium benzoate Sodium chloride Piperacillin Sodium

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PIPERACILLIN NA [2s-[2alpha,5alpha,6beta(s*)]]-6-[[[[(4-ethyl-2,3-dioxo-1-piperazinyl)carbonyl]amino]phenylacetyl]amino]-3,3-dimethyl-7-oxo-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid monosodium salt (2s-(2-alpha,5-alpha,6-beta(s*)))-msal 3-dimethyl-7-oxo--piperazinyl)carbonyl)amino)phenylacetyl)amino)-monosodiu 4-thia-1-azabicyclo(3.2.0)heptane-2-carboxylicacid,6-(((((4-ethyl-2,3-dioxo-1 cl227193 pentcillin pipril sodiumpiperacillin t1220 4-Thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid, 6-[[[[(4-ethyl-2,3-dioxo-1-piperazinyl)carbonyl]amino]phenylacetyl]amino]-3,3-dimethyl-7-oxo-, monosodium salt, [2S-[2alpha,5alpha,6beta(S*)]]- Piperacillin sodium sterile PIPERACILLIN SODIUM IMP. E (EP): 1-ETHYLPIPERAZINE-2,3-DIONE MM(CRM STANDARD) PIPERACILLIN SODIUM IMP. H (EP): 6-AMINOPENICILLANIC ACID MM(CRM STANDARD) PIPERACILLIN SODIUM MM(CRM STANDARD) PEPERACILLIN SODIUM 4-Thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid, 6-[[(2R)-[[(4-ethyl-2,3-dioxo-1-piperazinyl)carbonyl]amino]phenylacetyl]amino]-3,3-dimethyl-7-oxo-, monosodium salt, (2S,5R,6R)- (9CI) 4-Thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid, 6-[[[[(4-ethyl-2,3-dioxo-1-piperazinyl)carbonyl]amino]phenylacetyl]amino]-3,3-dimethyl-7-oxo-, monosodium salt, [2S-[2a,5a,6b(S*)]]- Piperacillin sodium salt DBL Piperacillin 6α-[(R)-Phenyl[(4-ethyl-2,3-dioxo-1-piperazinyl)carbonylamino]acetylamino]penicillanic acid sodium salt 6α-[[(R)-(4-Ethyl-2,3-dioxo-1-piperazinylcarbonylamino)phenylacetyl]amino]penicillanic acid sodium salt C07361 TazobactaM SodiuM (sterile one) 4-Thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid, 6-[[(2R)-2-[[(4-ethyl-2,3-dioxo-1-piperazinyl)carbonyl]amino]-2-phenylacetyl]amino]-3,3-dimethyl-7-oxo-, sodium salt (1:1), (2S,5R,6R)- (2s-(2alpha,5alpha,6beta(s*)))-6-(((((4-ethyl-2,3-dioxo-1-piperazinyl)carbonyl)amino)phenylacetyl)amino)-3,3-dimethyl-7-oxo-4-thia-1-azabicyclo(3.2.0)heptane-2-carboxylic acid mono TazobactaM SodiuM / Piperacillin SodiuM (2S,5R,6R)-6-[(R)-2-(4-Ethyl-2,3-dioxo-1-piperazinecarboxamido)-2-phenylacetamido]-3,3-dimethyl-7-oxo-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid sodium salt Piperacilin Sodium + Tazobactam Sodium(8：1) sodium (2R,5S,6S)-6-[[(2R)-2-[[(4-ethyl-2,3-dioxo-1-piperazinyl)-oxomethyl]amino]-1-oxo-2-phenylethyl]amino]-3,3-dimethyl-7-oxo-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylate Piperacillin sodium salt, 98%,HPLC Piperacilin Sodium Salt PiperacillinSodiumSalt> Piperacillin Sodium/Tazobactam Sodium(8:1) Sodium (2S,5R,6R)-6-((R)-2-(4-ethyl-2,3-dioxopiperazine-1-carboxamido)-2-phenylacetamido)-3,3-dimethyl-7-oxo-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylate Piperacillin sodium salt USP/EP/BP Piperacillin sodiumQ: What is Piperacillin sodium Q: What is the CAS Number of Piperacillin sodium Q: What is the storage condition of Piperacillin sodium Q: What are the applications of Piperacillin sodium PIPERACILLIN SODIUM Pipracillin sodium salt Glecaprevir Impurity 4 Sodium piperacillin|||CL227193|||Piperacillin sodium salt 59703-84-3 C23H26N5NaO7S C23H27N5O7SNa C6H10O4C4H10N2 C23H28N5O7SNa C23H26N5O7SNa BioChemical Antibiotics Antibiotics N-S Antibiotics A to Z Interferes with Cell Wall SynthesisSpectrum of Activity Antibacterial Antibiotics Antibiotics A to Antibiotics N-SAntibiotics Chemical Structure Class L - ZAntibiotics