Human Epidermal Growth Factor
- CAS No.
- 62253-63-8
- Chemical Name:
- Human Epidermal Growth Factor
- Synonyms
- EGF;sh-Oligopeptide-1;HEGF;RHEGF;NepiderMin;rh-Oligopeptide-1;HUMAN EPIDERMAL GROWTH FACTOR;EGP;NMEGF;HOMG4
- CBNumber:
- CB00123934
- Molecular Formula:
- C270H401N73O83S7
- Molecular Weight:
- 6221.96724
- MDL Number:
- MFCD00132565
- MOL File:
- 62253-63-8.mol
- MSDS File:
- SDS
| storage temp. | -20°C |
|---|---|
| form | powder |
| color | white |
| InChIKey | GVUGOAYIVIDWIO-UFWWTJHBSA-N |
| EWG's Food Scores | 1 |
| NCI Dictionary of Cancer Terms | EGF; epidermal growth factor |
| FDA UNII | TZK30RF92W |
| NCI Drug Dictionary | recombinant human epidermal growth factor |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|---|---|
| Signal word | Warning |
| Hazard statements | H335-H319-H315 |
| Precautionary statements | P264-P280-P302+P352-P321-P332+P313-P362-P264-P280-P305+P351+P338-P337+P313P |
| WGK Germany | 3 |
| RTECS | KB4518000 |
| F | 10-21 |
| HS Code | 2937190000 |
Human Epidermal Growth Factor price More Price(29)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | E9644 | hEGF EGF, recombinant, expressed in E. coli, lyophilized powder, suitable for cell culture | 62253-63-8 | 0.2mg | $254 | 2024-03-01 | Buy |
| Sigma-Aldrich | SAB4501796 | Anti-TACD1 antibody produced in rabbit affinity isolated antibody | 62253-63-8 | 100μg | $506 | 2024-03-01 | Buy |
| Sigma-Aldrich | E9644 | hEGF EGF, recombinant, expressed in E. coli, lyophilized powder, suitable for cell culture | 62253-63-8 | 0.5mg | $377 | 2024-03-01 | Buy |
| Sigma-Aldrich | E5036 | Epidermal Growth Factor, human, animal component free EGF, recombinant, expressed in Escherichia coli, >97% (SDS-PAGE) | 62253-63-8 | 200μg | $358 | 2024-03-01 | Buy |
| Sigma-Aldrich | E5036 | Epidermal Growth Factor, human, animal component free EGF, recombinant, expressed in Escherichia coli, >97% (SDS-PAGE) | 62253-63-8 | 500μg | $432 | 2024-03-01 | Buy |
Human Epidermal Growth Factor Chemical Properties,Uses,Production
Description
An ophthalmic formulation of epidermal growth factor (urogastrone) has been launched for stimulation of healing of the corneal epithelium following various corneal diseases.
Chemical Properties
Endotoxin < 0.1 ng per μg (1EU/ug) of EGF
Originator
Inpharzam (Italy)
Uses
This product is used as a mitogen, triggering the cell to commence mitosis, in a variety of cell lines. In tissue cultures, EGF acts to reduce or eliminate the requirement for serum and can be used in conjunction with other media additives and hormones.
Uses
EGF (epidermal growth factor) human has been used in the culture medium for the maintenance of MCF10A cells (human mammary epithelial cells).
Uses
Epidermal Growth Factor, human, animal component free has been used:
- as a supplement in in LHC-8 medium to culture liver cell lines
- in the fetal bovine serum (FBS)-Dulbecco′s modified essential medium (DMEM) /F12 medium for primary culture of human glioma cells
- as an additive in the conditional medium of normal fibroblasts (NFs) to study its effect on the migration and invasion of endometrial cancer (EC) cells
- as a component in tumorsphere medium
Application
Epidermal Growth Factor (EGF) is a human protein that is involved in the regulation of cell growth, differentiation and survival. Recombinant EGF is an antigen binding molecule that can be used as a cancer treatment. Recombinant EGF has been shown to stimulate cellular transformation by binding to the epidermal growth factor receptor. It also has been shown to inhibit the growth of breast cancer cells with the HER2 gene mutation. The molecular weight of rec EGF is approximately 25 kDa and is composed of 165 amino acids. Recombinant EGF can be used in immunoassays, as a model system for studying biological properties, or as an antibody production tool.
brand name
Gentel
General Description
Epidermal Growth Factor (EGF) is a small mitogenic polypeptide (～6 kDa), which is present in many mammalian species and is distributed throughout a wide number of tissues and body fluids.? Human EGF is identical to β-urogastrone, a polypeptide which was recognized and isolated on the basis of its ability to inhibit gastric acid secretion.? EGF is a member of a growth factor family, which is characterized by the presence of 6 conserved cysteine motifs that form three disulfide bonds. The location of 3 intrachain disulfide bonds in recombinant human EGF is identical to that of mouse EGF.? EGF is homologous to a sequence contained in a 19 kDa protein of vaccinia virus,? which appears to utilize the EGF receptor to gain entry into cell? EGF is mitogenic for a variety of epidermal and epithelial cells, including fibroblasts, glial cells, mammary epithelial cells, vascular and corneal endothelial cells, bovine granulosa, rabbit chondrocytes, HeLa cells, and SV40-3T3 cells.?
Biochem/physiol Actions
Epidermal growth factor (EGF) helps to induce cell growth, proliferation and differentiation. It participates in the repairing of renal tissues in the kidney. It promotes the reabsorption of magnesium with the help of the transient receptor potential cation channel 6 (TRMP6). EGF is known to participate in the pathophysiology of drug-induced renal magnesium loss.
Human Epidermal Growth Factor Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Chengdu Youngshe Chemical Co., Ltd. | +8618108235634 | Cecilia@youngshechem.com | China | 2345 | 58 |
| Hebei Weibang Biotechnology Co., Ltd | +8615531157085 | abby@weibangbio.com | China | 8810 | 58 |
| Hebei Mojin Biotechnology Co., Ltd | +86 13288715578 +8613288715578 | sales@hbmojin.com | China | 12839 | 58 |
| Anhui Ruihan Technology Co., Ltd | +8617756083858 | daisy@anhuiruihan.com | China | 973 | 58 |
| Shandong Hanjiang Chemical Co., Ltd | +86-0533-2066820 +8618369939125 | hanson@sdhanjiang.com | China | 999 | 58 |
| HEBEI SHENGSUAN CHEMICAL INDUSTRY CO.,LTD | +8615350851019 | admin@86-ss.com | China | 1001 | 58 |
| Shanghai Daken Advanced Materials Co.,Ltd | +86-371-66670886 | info@dakenam.com | China | 18775 | 58 |
| Henan Tianfu Chemical Co.,Ltd. | +86-0371-55170693 +86-19937530512 | info@tianfuchem.com | China | 21634 | 55 |
| Rixing Chemical CO.,LTD | +86-13237129059 -13237129059 | sales@rixingchemi.com | CHINA | 229 | 55 |
| career henan chemical co | +86-0371-86658258 +8613203830695 | sales@coreychem.com | China | 29881 | 58 |
View Lastest Price from Human Epidermal Growth Factor manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2024-09-23 | EPIDERMAL GROWTH FACTOR, HUMAN
62229-50-9
|
US $70.00 / kg | 1kg | 0.99 | 1000000tons | Wuhan Quanjinci New Material Co.,Ltd. | |
 |
2019-07-06 | EPIDERMAL GROWTH FACTOR, HUMAN
62229-50-9
|
US $8.00 / kg | 1kg | 98% | 10MT | Career Henan Chemical Co |
-
- EPIDERMAL GROWTH FACTOR, HUMAN
62229-50-9
- US $70.00 / kg
- 0.99
- Wuhan Quanjinci New Material Co.,Ltd.
-
- EPIDERMAL GROWTH FACTOR, HUMAN
62229-50-9
- US $8.00 / kg
- 98%
- Career Henan Chemical Co