Phenethylamine
- CAS No.
- 64-04-0
- Chemical Name:
- Phenethylamine
- Synonyms
- Phenylethylamine;PHENETHYLAMINE;BENZENEETHANAMINE;2-Phenylethanamine;2-PHENETHYLAMINE;BETA-PHENYLETHYLAMINE;β-phenylethylamine;FEMA 3220;Phenethylamine, 99.5%;beta-Phenylaethylamin
- CBNumber:
- CB00126130
- Molecular Formula:
- C8H11N
- Molecular Weight:
- 121.18
- MDL Number:
- MFCD00008184
- MOL File:
- 64-04-0.mol
| Melting point | -60 °C |
|---|---|
| Boiling point | 197-200 °C (lit.) |
| Density | 0.962 g/mL at 20 °C (lit.) |
| vapor density | 4.18 (vs air) |
| vapor pressure | 0.4 hPa (20 °C) |
| refractive index |
n |
| FEMA | 3220 | PHENETHYLAMINE |
| Flash point | 195 °F |
| storage temp. | Store below +30°C. |
| solubility | alcohol: freely soluble(lit.) |
| pka | 9.84(at 25℃) |
| form | liquid |
| color | clear, colorless |
| PH | 11.5 (4.3g/l, H2O, 20℃) |
| Odor | fishy odor |
| PH Range | 11.5 at 4.3 g/l at 20 °C |
| explosive limit | 1.0-5.5%(V) |
| Odor Type | fishy |
| Viscosity | 2.40 mm2/s at 23 °C |
| Water Solubility | SOLUBLE |
| Sensitive | Air Sensitive |
| JECFA Number | 1589 |
| Merck | 14,6026 |
| BRN | 507488 |
| Stability | Stable. Combustible. Incompatible with strong oxidizing agents, strong acids. |
| InChIKey | BHHGXPLMPWCGHP-UHFFFAOYSA-N |
| LogP | 1.46 |
| Substances Added to Food (formerly EAFUS) | PHENETHYLAMINE |
| CAS DataBase Reference | 64-04-0(CAS DataBase Reference) |
| EWG's Food Scores | 1 |
| FDA UNII | 327C7L2BXQ |
| NIST Chemistry Reference | Benzeneethanamine(64-04-0) |
| EPA Substance Registry System | Phenethylamine (64-04-0) |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |   GHS05,GHS06 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Danger | |||||||||
| Hazard statements | H290-H301-H314 | |||||||||
| Precautionary statements | P234-P270-P280-P303+P361+P353-P304+P340+P310-P305+P351+P338 | |||||||||
| Hazard Codes | C | |||||||||
| Risk Statements | 22-34 | |||||||||
| Safety Statements | 26-36/37/39-45 | |||||||||
| RIDADR | UN 2922 8/PG 2 | |||||||||
| WGK Germany | 1 | |||||||||
| RTECS | SG8750000 | |||||||||
| F | 9-23 | |||||||||
| Autoignition Temperature | 425 °C | |||||||||
| TSCA | Yes | |||||||||
| HazardClass | 8 | |||||||||
| PackingGroup | III | |||||||||
| HS Code | 29214980 | |||||||||
| Toxicity | LD50 orally in Rabbit: 300 mg/kg | |||||||||
| NFPA 704 |
|
Phenethylamine Chemical Properties,Uses,Production
Chemical Properties
Phenethylamine has a fish odor.
Chemical Properties
colourless or slightly yellow liquid with
Occurrence
Reported found in the oil of bitter almonds. Also found in grapes, cabbage, kale, carrots, blue and provolone cheese, fatty fish, beer, sherry, grape wines, cocoa, cauliflower, beetroot, radish, rhubarb, sake and dried bonito.
Uses
Phenethylamine is used in manufacturing anti-depression agents and anti diabetic drugs. It is also used as the goodds for drug jiangtangling intermediate, also used for other organic synthesis.
Definition
ChEBI: A phenylethylamine having the phenyl substituent at the 2-position.
Preparation
By reduction of benzyl cyanide with sodium metal in alcohol or with Raney-Ni.
Synthesis Reference(s)
Chemical and Pharmaceutical Bulletin, 34, p. 3905, 1986 DOI: 10.1248/cpb.34.3905
Journal of the American Chemical Society, 94, p. 6561, 1972 DOI: 10.1021/ja00773a060
Tetrahedron Letters, 21, p. 1719, 1980 DOI: 10.1016/S0040-4039(00)77819-1
General Description
Phenethylamine, a new stimulant designer drug, was analyzed by the liquid chromatography high-resolution mass spectrometry quadrupole-time-of-flight (LC-HRMS-QTOF) method.
Safety Profile
Poison by intraperitoneal, subcutaneous, intracervical, and intravenous routes. Moderately toxic by ingestion. A strong base. A skin irritant and possible sensitizer. When heated to decomposition it emits toxic fumes of NOx. See also AMINES
Purification Methods
Distil the amine from CaH2, under reduced pressure, just before use. [Beilstein 12 H 1096, 12 IV 2453.]
Phenethylamine Preparation Products And Raw materials
Raw materials
Preparation Products
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