Tissue Plasminogen Activator
- CAS No.
- 189263-81-8
- Chemical Name:
- Tissue Plasminogen Activator
- Synonyms
- TISSUE PLASMINOGEN ACTIVATOR;TPA;TPA, HUMAN;1-CHAIN TPA;2-CHAIN TPA;TISSUE PLASMINOGEN ACTIVATOR, HUMAN;TISSUE PLASMINOGEN ACTIVATOR 2-CHAIN;TISSUE PLASMINOGEN ACTIVATOR 1-CHAIN;9,10-Bis[N-(m-tolyl)anilino]anthracene;9,10-Bis[N-(m-tolyl)anilino]anthracene
- CBNumber:
- CB00127920
- Molecular Formula:
- C40H32N2
- Molecular Weight:
- 540.7
- MDL Number:
- MFCD00166068
- MOL File:
- 189263-81-8.mol
- MSDS File:
- SDS
Melting point | 262 °C |
---|---|
Boiling point | 723.8±53.0 °C(Predicted) |
Density | 1.194±0.06 g/cm3(Predicted) |
storage temp. | 2-8°C |
pka | -0.33±0.50(Predicted) |
form | Lyophilized |
color | Light yellow to Yellow to Orange |
NCI Dictionary of Cancer Terms | tissue plasminogen activator; tPA |
SAFETY
Risk and Safety Statements
Symbol(GHS) | GHS07 |
---|---|
Signal word | Warning |
Hazard statements | H315-H319-H335 |
Precautionary statements | P261-P305+P351+P338 |
Hazard Codes | Xn |
Risk Statements | 22-36/37/38 |
Safety Statements | 26-36 |
WGK Germany | 1 |
HS Code | 2921.59.8090 |
Tissue Plasminogen Activator price More Price(37)
Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
---|---|---|---|---|---|---|---|
Sigma-Aldrich | T0831 | Tissue plasminogen activator human | 100μG | $512 | 2023-06-20 | Buy | |
Sigma-Aldrich | T0831 | Tissue plasminogen activator human | 189263-81-8 | 1MG | $1150 | 2023-06-20 | Buy |
Sigma-Aldrich | T0831 | Tissue plasminogen activator human | 189263-81-8 | 100UG | $426 | 2022-05-15 | Buy |
TCI Chemical | B4965 | 9,10-Bis[N-(m-tolyl)anilino]anthracene >98.0%(HPLC) | 189263-81-8 | 1g | $268 | 2024-03-01 | Buy |
TCI Chemical | B4965 | 9,10-Bis[N-(m-tolyl)anilino]anthracene >98.0%(HPLC) | 189263-81-8 | 200mg | $78 | 2024-03-01 | Buy |
Tissue Plasminogen Activator Chemical Properties,Uses,Production
Chemical Properties
off-white powder
Uses
Tissue plasminogen activator has been used in a study to assess treatment risks of intracranial hemorrhage among patients with acute ischemic stroke. Tissue plasminogen activator has also been used in a study to investigate the successful treatment of early thrombosis of HeartWare left ventricular assist devices with intraventricular thrombolytics. Human tissue plasminogen activator has been used to study the effect of tyrosinase-related protein 2 (TRP-2) expression on melanin production in sheep.
General Description
Recombinant tPA (rtPA), alteplase (Activase), is identicalwith endogenous tPA. rtPA lacks a glycosyl residue atAsn184. At one time, rtPA was produced in two-chain formin CHO cultures. Now, large-scale cultures of recombinanthuman melanoma cells in fermenters are used to produce aproduct that is about 80% single-chain rtPA.
Alteplase is used to improve ventricular function followingan acute myocardial infarction, including reducing the incidenceof congestive heart failure and decreasing mortality.The drug is also used to treat acute ischemic stroke aftercomputed tomography (CT) or other diagnostic imaging hasruled out intracranial hemorrhage. rtPA is also used in casesof acute pulmonary thromboembolism and is being investigatedfor unstable angina pectoris.
Alteplase is supplied as powder for injection, and in reconstitutedform (normal saline or 5% dextrose in water) isintended for IV infusion only. The solution expires in 8 hoursat room temperature and must be prepared just before use.
Biochem/physiol Actions
tPA is a potent activator of fibrinolysis and converts plasminogen into plasmin and also initiates cell signaling. The plasminogen activation system may also be associated with degradation of amyloid fibrils. It is also known to mediate inflammatory and extracellular matrix remodeling processes and is predicted to participate in disease progression of intracranial aneurysm indicating brain vascular malformations. Upregulation of the gene is observed in aortic aneurysms.
Tissue Plasminogen Activator Preparation Products And Raw materials
Raw materials
Preparation Products
Tissue Plasminogen Activator Suppliers
Supplier | Tel | Country | ProdList | Advantage | |
---|---|---|---|---|---|
Career Henan Chemica Co | +86-0371-86658258 +8613203830695 | laboratory@coreychem.com | China | 30250 | 58 |
Alfa Chemistry | Info@alfa-chemistry.com | United States | 24072 | 58 | |
Hangzhou MolCore BioPharmatech Co.,Ltd. | +86-057181025280; +8617767106207 | sales@molcore.com | China | 49739 | 58 |
LEAPCHEM CO., LTD. | +86-852-30606658 | market18@leapchem.com | China | 43348 | 58 |
Aladdin Scientific | +1-+1(833)-552-7181 | sales@aladdinsci.com | United States | 57511 | 58 |
Amadis Chemical Company Limited | 571-89925085 | sales@amadischem.com | China | 131980 | 58 |
TCI (Shanghai) Development Co., Ltd. | 021-67121386 | Sales-CN@TCIchemicals.com | China | 24539 | 81 |
Shijiazhuang Sdyano Fine Chemical Co., Ltd. | 0311-89250318 031166536426 | master@sjzsdyn.com | China | 2967 | 65 |
Adamas Reagent, Ltd. | 400-6009262 16621234537 | chenyj@titansci.com | China | 14104 | 59 |
Xi’an Caijing Opto-Electrical Science and Technology Co.,Ltd | 029-88294447 029-88292246 029-88296135 | cjoesale@xacjoe.com | China | 221 | 62 |
View Lastest Price from Tissue Plasminogen Activator manufacturers
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2020-04-21 | NBCA n-butyl cyanoacrylate tissue adhesive
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US $300.00 / Kg/Drum | 1g | 99% | 500 ton | Cangzhou Wanyou New Material Technology Co.,Ltd | ||
2020-02-19 | Prostratin, PKC activator
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US $7.00 / KG | 1KG | 99% | 100kg | Career Henan Chemical Co | ||
2020-02-19 | Prostratin, PKC activator
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US $7.00 / KG | 1KG | 99% | 100kg | Career Henan Chemical Co |
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