Propranolol Hcl
- CAS No.
- 318-98-9
- Chemical Name:
- Propranolol Hcl
- Synonyms
- PROPRANOLOL HCL;inderal;inderol;anaprilin;Dibudinate;InnoPran XL;kemi;Nedis;Ikopal;Herzul
- CBNumber:
- CB00128713
- Molecular Formula:
- C16H22ClNO2
- Molecular Weight:
- 295.8
- MDL Number:
- MFCD00012558
- MOL File:
- 318-98-9.mol
Melting point | 163-165 °C(lit.) |
---|---|
Flash point | 9℃ |
storage temp. | 2-8°C |
solubility | H2O: 50 mg/mL, clear, colorless |
form | powder |
color | white |
Water Solubility | SOLUBLE |
Merck | 14,7840 |
BRN | 4164259 |
BCS Class | 1 |
InChIKey | ZMRUPTIKESYGQW-UHFFFAOYSA-N |
CAS DataBase Reference | 318-98-9(CAS DataBase Reference) |
FDA UNII | F8A3652H1V |
NCI Dictionary of Cancer Terms | Inderal; propranolol hydrochloride |
NCI Drug Dictionary | Inderal |
EPA Substance Registry System | Propranolol hydrochloride (318-98-9) |
SAFETY
Risk and Safety Statements
Symbol(GHS) | GHS07 |
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Signal word | Warning | |||||||||
Hazard statements | H302 | |||||||||
Precautionary statements | P301+P312+P330 | |||||||||
Hazard Codes | Xn,Xi,T,F | |||||||||
Risk Statements | 22-39/23/24/25-23/24/25-11 | |||||||||
Safety Statements | 22-45-36/37-16-7 | |||||||||
RIDADR | UN1230 - class 3 - PG 2 - Methanol, solution | |||||||||
WGK Germany | 3 | |||||||||
RTECS | UB7525000 | |||||||||
F | 10 | |||||||||
HazardClass | IRRITANT | |||||||||
HS Code | 29221990 | |||||||||
Toxicity | LD50 in mice (mg/kg): 565 orally; 22 i.v.; 107 i.p. (Martin, Linee) | |||||||||
NFPA 704 |
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Propranolol Hcl price More Price(36)
Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
---|---|---|---|---|---|---|---|
Sigma-Aldrich | P-055 | Propranolol hydrochloride solution 1.0?mg/mL in methanol (as free base), ampule of 1?mL, certified reference material, Cerilliant? | 318-98-9 | 1mL | $36.6 | 2024-03-01 | Buy |
Sigma-Aldrich | 40543 | (±)-Propranolol hydrochloride analytical standard | 318-98-9 | 100mg | $83.8 | 2024-03-01 | Buy |
Sigma-Aldrich | 1576005 | Propranolol hydrochloride United States Pharmacopeia (USP) Reference Standard | 318-98-9 | 200mg | $436 | 2024-03-01 | Buy |
Alfa Aesar | H26645 | (±)-Propranolol hydrochloride, 99% | 318-98-9 | 5g | $82.4 | 2024-03-01 | Buy |
Alfa Aesar | H26645 | (±)-Propranolol hydrochloride, 99% | 318-98-9 | 25g | $257 | 2024-03-01 | Buy |
Propranolol Hcl Chemical Properties,Uses,Production
Description
Propranolol hydrochloride is a off-white to light-yellow cyrstalline solid, easily soluble in ethanol and water.
Uses
Propranolol Hcl is a beta blocker used to treat high blood pressure, irregular heartbeats, shaking (tremors), and other conditions. It is used after a heart attack to improve the chance of survival. It is also used to prevent migraine headaches and chest pain (angina).
Brand name
Inderal,Avlocardyl, Deralin, Dociton, Inderalici, InnoPran XL, Indoblok,Sumial, Anaprilin, and Bedranol SR (Sandoz),Ciplar,Ciplar LA
Mechanism of action
Propranolol is classified as a competitive non-cardioselective sympatholytic beta blocker that crosses the blood–brain barrier. It is lipid soluble and also has sodium channel blocking effects. Propranolol is a non-selective β-adrenergic receptor antagonist, or beta blocker.Propranolol is able to cross the blood–brain barrier and exert effects in the central nervous system in addition to its peripheral activity.
Pharmacokinetics
Propranolol Hcl is rapidly and completely absorbed, with peak plasma levels achieved about 1–3 hours after ingestion. More than 90% of the drug is found bound to plasma protein in the blood.Coadministration with food appears to enhance bioavailability.Despite complete absorption, propranolol has a variable bioavailability due to extensive first-pass metabolism. Hepatic impairment therefore increases its bioavailability. The main metabolite 4-hydroxypropranolol, with a longer half-life (5.2–7.5 hours) than the parent compound (3–4 hours), is also pharmacologically active. Most of the metabolites are excreted in the urine.
Side effects
Common side effects include nausea, abdominal pain, and constipation.It may worsen the symptoms of asthma.Propranolol may cause harmful effects for the baby if taken during pregnancy.
Propranolol Hcl Preparation Products And Raw materials
Raw materials
Preparation Products
Supplier | Tel | Country | ProdList | Advantage | |
---|---|---|---|---|---|
Huadong Medicine (Xi'an)Bodyguard Pharmaceutical Co.,Ltd. | +86-029-86185165 +8618629664246 | guoyuan@eastchinapharm.com | China | 1615 | 58 |
Henan Fengda Chemical Co., Ltd | +86-371-86557731 +86-13613820652 | info@fdachem.com | China | 20290 | 58 |
Henan Tianfu Chemical Co.,Ltd. | +86-0371-55170693 +86-19937530512 | info@tianfuchem.com | China | 21661 | 55 |
Hubei XinRunde Chemical Co., Ltd. | +8615102730682 | bruce@xrdchem.cn | CHINA | 566 | 55 |
Hefei TNJ Chemical Industry Co.,Ltd. | +86-0551-65418679 +8618949832763 | info@tnjchem.com | China | 2989 | 55 |
career henan chemical co | +86-0371-86658258 +8613203830695 | sales@coreychem.com | China | 29899 | 58 |
Hubei Jusheng Technology Co.,Ltd. | 18871490254 | linda@hubeijusheng.com | CHINA | 28180 | 58 |
Xiamen AmoyChem Co., Ltd | +86-86-5926051114 +8618959220845 | sales@amoychem.com | China | 6387 | 58 |
Hubei xin bonus chemical co. LTD | 86-13657291602 | linda@hubeijusheng.com | CHINA | 22968 | 58 |
Chongqing Chemdad Co., Ltd | +86-023-6139-8061 +86-86-13650506873 | sales@chemdad.com | China | 39916 | 58 |
View Lastest Price from Propranolol Hcl manufacturers
Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
---|---|---|---|---|---|---|---|---|
2024-10-18 | Propranolol
525-66-6
|
US $0.00 / kg | 1kg | 99% | 20tons | Sinoway Industrial co., ltd. | ||
2020-01-10 | R(+)-PROPRANOLOL HCL
5051-22-9
|
US $7.00 / KG | 1KG | 99% | 100KG | Career Henan Chemical Co | ||
2019-07-06 | Propranolol hydrochloride
318-98-9
|
US $8.00 / kg | 1kg | 99% | 10tons | Career Henan Chemical Co |
- Propranolol
525-66-6
- US $0.00 / kg
- 99%
- Sinoway Industrial co., ltd.
- R(+)-PROPRANOLOL HCL
5051-22-9
- US $7.00 / KG
- 99%
- Career Henan Chemical Co
- Propranolol hydrochloride
318-98-9
- US $8.00 / kg
- 99%
- Career Henan Chemical Co
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