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ChemicalBook >> CAS DataBase List >>Benzamide, 2-(6-azaspiro[2.5]oct-6-yl)-N-[3-[[(1,1-dimethylethyl)amino]sulfonyl]phenyl]-4-[[(1-methylcyclopropyl)sulfonyl]amino]-

Benzamide, 2-(6-azaspiro[2.5]oct-6-yl)-N-[3-[[(1,1-dimethylethyl)amino]sulfonyl]phenyl]-4-[[(1-methylcyclopropyl)sulfonyl]amino]-

Benzamide, 2-(6-azaspiro[2.5]oct-6-yl)-N-[3-[[(1,1-dimethylethyl)amino]sulfonyl]phenyl]-4-[[(1-methylcyclopropyl)sulfonyl]amino]- Structure
Benzamide, 2-(6-azaspiro[2.5]oct-6-yl)-N-[3-[[(1,1-dimethylethyl)amino]sulfonyl]phenyl]-4-[[(1-methylcyclopropyl)sulfonyl]amino]- structure
CAS No.
2600577-49-7
Chemical Name:
Benzamide, 2-(6-azaspiro[2.5]oct-6-yl)-N-[3-[[(1,1-dimethylethyl)amino]sulfonyl]phenyl]-4-[[(1-methylcyclopropyl)sulfonyl]amino]-
Synonyms
KIF18A-IN-3;2-{6-azaspiro[2.5]octan-6-yl}-N-[3-(tert-butylsulfamoyl)phenyl]-4-(1-methylcyclopropanesulfonamido)benzamide;Benzamide, 2-(6-azaspiro[2.5]oct-6-yl)-N-[3-[[(1,1-dimethylethyl)amino]sulfonyl]phenyl]-4-[[(1-methylcyclopropyl)sulfonyl]amino]-
CBNumber:
CB010729755
Molecular Formula:
C28H38N4O5S2
Molecular Weight:
574.76
MDL Number:
MOL File:
2600577-49-7.mol
Last updated:2024-11-19 20:33:22
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Benzamide, 2-(6-azaspiro[2.5]oct-6-yl)-N-[3-[[(1,1-dimethylethyl)amino]sulfonyl]phenyl]-4-[[(1-methylcyclopropyl)sulfonyl]amino]- Properties

Density 1.37±0.1 g/cm3(Predicted)
storage temp. Store at -20°C
form Solid
pka 8.51±0.20(Predicted)
color White to off-white

Benzamide, 2-(6-azaspiro[2.5]oct-6-yl)-N-[3-[[(1,1-dimethylethyl)amino]sulfonyl]phenyl]-4-[[(1-methylcyclopropyl)sulfonyl]amino]- Chemical Properties,Uses,Production

Biological Activity

KIF18A-IN-3 is a potent KIF18A inhibitor (IC50=61 nM). KIF18A-IN-3 causes significant mitotic arrest and increases the number of mitotic cells in tumor tissues. KIF18A-IN-3 can be used for researching cancer[1]. KIF18A-IN-3 (compound 24) exhibits a significant and sustained pharmacodynamic response, increasing the number of mitotic cells (pH3 positive cells) in tumor tissues for up to 24 hours[1].Pharmacokinetic Parameters of KIF18A-IN-3 in female CD-1 mice[1]. IP (100 mg/kg) Cmax (μM)26.5AUC0-24 (μM.h)269 C24h (μM)0.8PPB (fu)0.015

References

[1]. Tamayo NA, et al. Targeting the Mitotic Kinesin KIF18A in Chromosomally Unstable Cancers: Hit Optimization Toward an In Vivo Chemical Probe. J Med Chem. 2022;65(6):4972-4990.

Benzamide, 2-(6-azaspiro[2.5]oct-6-yl)-N-[3-[[(1,1-dimethylethyl)amino]sulfonyl]phenyl]-4-[[(1-methylcyclopropyl)sulfonyl]amino]- Preparation Products And Raw materials

Raw materials

Preparation Products

Benzamide, 2-(6-azaspiro[2.5]oct-6-yl)-N-[3-[[(1,1-dimethylethyl)amino]sulfonyl]phenyl]-4-[[(1-methylcyclopropyl)sulfonyl]amino]- Suppliers

Global( 12)Suppliers
Supplier Tel Email Country ProdList Advantage
ATK CHEMICAL COMPANY LIMITED 		+undefined-21-51877795 ivan@atkchemical.com China 32957 60
TargetMol Chemicals Inc. 		+8613564774135 zijue.cai@tsbiochem.com United States 19885 58
Shanghai Lollane Biological Technology Co.,Ltd. 021-52996696，15000506266 15000506266 China 4512 55
Shanghai Chaolan Chemical Technology Center 021-QQ：65489617 15618227136 Sales@ATKchemical.com China 7268 58
DC Chemicals 021-58447131 13564518121 sales@dcchemicals.com China 9409 58
Suzhou youruike Chemical Pharmaceutical Technology Co., Ltd 15317229551 15151849396@163.com China 994 58
TargetMol Chemicals Inc. 4008200310 marketing@tsbiochem.com China 24647 58
Xianning Shen Lan Biomedical Research and Development Co., Ltd. 18171815831 1341138380@qq.com China 3394 58
Nantong QuanYi Biotechnology Co., Ltd 0513-66337626 18051384581 sales@chemhifuture.com China 4933 58
Nanjing Tengyi Biotechnology Co., Ltd 025-58851786 17714337195 sales@tybiochem.com China 6813 58
Supplier Advantage
ATK CHEMICAL COMPANY LIMITED 		60
TargetMol Chemicals Inc. 		58
Shanghai Lollane Biological Technology Co.,Ltd. 55
Shanghai Chaolan Chemical Technology Center 58
DC Chemicals 58
Suzhou youruike Chemical Pharmaceutical Technology Co., Ltd 58
TargetMol Chemicals Inc. 58
Xianning Shen Lan Biomedical Research and Development Co., Ltd. 58
Nantong QuanYi Biotechnology Co., Ltd 58
Nanjing Tengyi Biotechnology Co., Ltd 58

View Lastest Price from Benzamide, 2-(6-azaspiro[2.5]oct-6-yl)-N-[3-[[(1,1-dimethylethyl)amino]sulfonyl]phenyl]-4-[[(1-methylcyclopropyl)sulfonyl]amino]- manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
KIF18A-IN-3 pictures 2024-11-19 KIF18A-IN-3
2600577-49-7
 US $1940.00-3110.00 / mg 10g TargetMol Chemicals Inc.
  • KIF18A-IN-3 pictures
  • KIF18A-IN-3
    2600577-49-7
  • US $1940.00-3110.00 / mg
  • TargetMol Chemicals Inc.
Benzamide, 2-(6-azaspiro[2.5]oct-6-yl)-N-[3-[[(1,1-dimethylethyl)amino]sulfonyl]phenyl]-4-[[(1-methylcyclopropyl)sulfonyl]amino]- KIF18A-IN-3 2-{6-azaspiro[2.5]octan-6-yl}-N-[3-(tert-butylsulfamoyl)phenyl]-4-(1-methylcyclopropanesulfonamido)benzamide 2600577-49-7