ChemicalBook >> CAS DataBase List >>BI-0474

BI-0474

BI-0474 structure

CAS No.: 2750570-55-7

Chemical Name:: BI-0474

Synonyms: BI-0474;Benzo[b]thiophene-3-carbonitrile, 2-amino-4-[3-[6-[(2S)-2,4-dimethyl-1-piperazinyl]-4-[4-(1-oxo-2-propen-1-yl)-1-piperazinyl]-2-pyridinyl]-1,2,4-oxadiazol-5-yl]-4,5,6,7-tetrahydro-4-methyl-, (4S)-

CBNumber:: CB012245556

Molecular Formula:: C30H37N9O2S

Molecular Weight:: 587.74

MDL Number:

MOL File:: 2750570-55-7.mol

Last updated:2024-11-19 15:53:33

Request For Quotation

BI-0474 Properties

Boiling point	879.4±75.0 °C(Predicted)
Density	1.38±0.1 g/cm3(Predicted)
pka	7.13±0.70(Predicted)
form	Solid
color	White to off-white
InChIKey	CKAMBYUZKWQCKJ-ADSBAMQRSA-N
SMILES	C12CCC[C@@](C3ON=C(C4=NC(N5CCN(C)C[C@@H]5C)=CC(N5CCN(C(=O)C=C)CC5)=C4)N=3)(C)C=1C(C#N)=C(N)S2

BI-0474 Chemical Properties,Uses,Production

Description

BI-0474 is a potent KRASG12C inhibitor with an IC50 value of 7.0 nM.

Uses

BI-0474 is a potent KRAS^G12C inhibitor with an IC₅₀ value of 7.0 nM for the GDP-KRAS::SOS1 protein-protein interaction. It exhibits good anti-proliferative activity against NCI-H358 cells carrying the G12C mutation. BI-0474 also shows good anti-tumour activity in non-small cell lung cancer xenograft models.

in vitro

BI-0474 (1-10,000 nM; 3 days) shows potent antiproliferative activity of 26 nM on NCI-H358 cells carrying a G12C mutation.

in vivo

BI-0474 (40 mg/kg; i.p.; single daily for 3 days) shows anti-tumor efficacy and pharmacodynamic biomarker modulation in an NCI-H358 cell line-derived non-small cell lung cancer xenograft model

BI-0474 Preparation Products And Raw materials

Raw materials

Preparation Products

BI-0474 Suppliers

Global( 30)Suppliers

Supplier	Tel	Email	Country	ProdList	Advantage
Hubei Chuchang Biotech Co., Ltd.	+undefined15623860702	info@chuchangbiotech.com	China	203	58
TargetMol Chemicals Inc.	+1-781-999-5354 +1-00000000000	marketing@targetmol.com	United States	32161	58
Wuhan Jingkang en Biomedical Technology Co., Ltd	+8613720134139	orders@jknbiochem.com	China	5221	58
Hubei Chuchang Chemical Co., Ltd	18; 15623560702	Joy.Ren@aliyun.com	China	160	58
Changzhou Borl Biotechnology Co.,LTD	13606124132;13656121842	luyan0021@163.com	China	218	58
ShangHai Caerulum Pharma Discovery Co., Ltd.	18149758185 18149758185	sales-cpd@caerulumpharma.com	China	3466	58
Shanghai Lollane Biological Technology Co.,Ltd.	021-52996696，15000506266 15000506266		China	4573	55
ShangHai Angti Biotechnology Co., Ltd.	13764913901	info@angtibio.com	China	5028	55
ShangHai Biochempartner Co.,Ltd	17754423994 17754423994	2853530910@QQ.com	China	8011	62
Shanghai Rechem science Co., Ltd.	21-31433387 15618786686	sales@rechemscience.com	China	2998	58

Supplier	Advantage
Hubei Chuchang Biotech Co., Ltd.	58
TargetMol Chemicals Inc.	58
Wuhan Jingkang en Biomedical Technology Co., Ltd	58
Hubei Chuchang Chemical Co., Ltd	58
Changzhou Borl Biotechnology Co.,LTD	58
ShangHai Caerulum Pharma Discovery Co., Ltd.	58
Shanghai Lollane Biological Technology Co.,Ltd.	55
ShangHai Angti Biotechnology Co., Ltd.	55
ShangHai Biochempartner Co.,Ltd	62
Shanghai Rechem science Co., Ltd.	58

View Lastest Price from BI-0474 manufacturers

Image	Update time	Product	Price	Min. Order	Purity	Supply Ability	Manufacturer
	2025-01-15	BI-0474 2750570-55-7	US $0.00-0.00 / mg	5mg	98%+ HPLC HNMR	10g	Hubei Chuchang Biotech Co., Ltd.
	2024-11-19	BI-0474 2750570-55-7	US $388.00-1230.00 / mg		100%	10g	TargetMol Chemicals Inc.

BI-0474
2750570-55-7
US $0.00-0.00 / mg
98%+ HPLC HNMR
Hubei Chuchang Biotech Co., Ltd.

BI-0474
2750570-55-7
US $388.00-1230.00 / mg
100%
TargetMol Chemicals Inc.

Benzo[b]thiophene-3-carbonitrile, 2-amino-4-[3-[6-[(2S)-2,4-dimethyl-1-piperazinyl]-4-[4-(1-oxo-2-propen-1-yl)-1-piperazinyl]-2-pyridinyl]-1,2,4-oxadiazol-5-yl]-4,5,6,7-tetrahydro-4-methyl-, (4S)- BI-0474 2750570-55-7 C30H37N9O2S