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BI-0474

BI-0474 Structure
BI-0474 structure
CAS No.
2750570-55-7
Chemical Name:
BI-0474
Synonyms
BI-0474;Benzo[b]thiophene-3-carbonitrile, 2-amino-4-[3-[6-[(2S)-2,4-dimethyl-1-piperazinyl]-4-[4-(1-oxo-2-propen-1-yl)-1-piperazinyl]-2-pyridinyl]-1,2,4-oxadiazol-5-yl]-4,5,6,7-tetrahydro-4-methyl-, (4S)-
CBNumber:
CB012245556
Molecular Formula:
C30H37N9O2S
Molecular Weight:
587.74
MDL Number:
MOL File:
2750570-55-7.mol
Last updated:2024-07-02 08:54:55
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BI-0474 Properties

Boiling point 879.4±75.0 °C(Predicted)
Density 1.38±0.1 g/cm3(Predicted)
pka 7.13±0.70(Predicted)
form Solid
color White to off-white
InChIKey CKAMBYUZKWQCKJ-ADSBAMQRSA-N
SMILES C12CCC[C@@](C3ON=C(C4=NC(N5CCN(C)C[C@@H]5C)=CC(N5CCN(C(=O)C=C)CC5)=C4)N=3)(C)C=1C(C#N)=C(N)S2

BI-0474 Chemical Properties,Uses,Production

Description

BI-0474 is a potent KRASG12C inhibitor with an IC50 value of 7.0 nM.

Uses

BI-0474 is a potent KRASG12C inhibitor with an IC50 value of 7.0 nM for the GDP-KRAS::SOS1 protein-protein interaction. It exhibits good anti-proliferative activity against NCI-H358 cells carrying the G12C mutation. BI-0474 also shows good anti-tumour activity in non-small cell lung cancer xenograft models.

in vitro

BI-0474 (1-10,000 nM; 3 days) shows potent antiproliferative activity of 26 nM on NCI-H358 cells carrying a G12C mutation.

in vivo

BI-0474 (40 mg/kg; i.p.; single daily for 3 days) shows anti-tumor efficacy and pharmacodynamic biomarker modulation in an NCI-H358 cell line-derived non-small cell lung cancer xenograft model

BI-0474 Preparation Products And Raw materials

Raw materials

Preparation Products

BI-0474 Suppliers

Global( 23)Suppliers
Supplier Tel Email Country ProdList Advantage
Hubei Chuchang Biotech Co., Ltd.
+86-18727130788 +86-18727130788 info@chuchangbiotech.com China 109 58
Wuhan Jingkang en Biomedical Technology Co., Ltd 		+8613720134139 orders@jknbiochem.com China 4692 58
Hubei Chuchang Chemical Co., Ltd 15623560702 Joy.Ren@aliyun.com China 144 58
Changzhou Borl Biotechnology Co.,LTD 13606124132;13656121842 luyan0021@163.com China 217 58
ShangHai Caerulum Pharma Discovery Co., Ltd. 18149758185 sales-cpd@caerulumpharma.com China 3453 58
Shanghai Lollane Biological Technology Co.,Ltd. 021-52996696，15000506266 15000506266 China 4197 55
ShangHai Angti Biotechnology Co., Ltd. 13764913901 info@angtibio.com China 4869 55
ShangHai Biochempartner Co.,Ltd 17754423994 17754423994 2853530910@QQ.com China 8012 62
Shanghai Rechem science Co., Ltd. 21-31433387 15618786686 sales@rechemscience.com China 2986 58
DC Chemicals 021-58447131 13564518121 sales@dcchemicals.com China 9412 58
Supplier Advantage
Hubei Chuchang Biotech Co., Ltd.
58
Wuhan Jingkang en Biomedical Technology Co., Ltd 		58
Hubei Chuchang Chemical Co., Ltd 58
Changzhou Borl Biotechnology Co.,LTD 58
ShangHai Caerulum Pharma Discovery Co., Ltd. 58
Shanghai Lollane Biological Technology Co.,Ltd. 55
ShangHai Angti Biotechnology Co., Ltd. 55
ShangHai Biochempartner Co.,Ltd 62
Shanghai Rechem science Co., Ltd. 58
DC Chemicals 58

View Lastest Price from BI-0474 manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
BI-0474 pictures 2024-07-13 BI-0474
2750570-55-7
 US $0.00-0.00 / mg 5mg 98%+ HPLC HNMR 10g Hubei Chuchang Biotech Co., Ltd.
  • BI-0474 pictures
  • BI-0474
    2750570-55-7
  • US $0.00-0.00 / mg
  • 98%+ HPLC HNMR
  • Hubei Chuchang Biotech Co., Ltd.
Benzo[b]thiophene-3-carbonitrile, 2-amino-4-[3-[6-[(2S)-2,4-dimethyl-1-piperazinyl]-4-[4-(1-oxo-2-propen-1-yl)-1-piperazinyl]-2-pyridinyl]-1,2,4-oxadiazol-5-yl]-4,5,6,7-tetrahydro-4-methyl-, (4S)- BI-0474 2750570-55-7 C30H37N9O2S