BI-0474
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BI-0474 속성
- 끓는 점
- 879.4±75.0 °C(Predicted)
- 밀도
- 1.38±0.1 g/cm3(Predicted)
- 산도 계수 (pKa)
- 7.13±0.70(Predicted)
- 물리적 상태
- Solid
- 색상
- White to off-white
- InChIKey
- CKAMBYUZKWQCKJ-ADSBAMQRSA-N
- SMILES
- C12CCC[C@@](C3ON=C(C4=NC(N5CCN(C)C[C@@H]5C)=CC(N5CCN(C(=O)C=C)CC5)=C4)N=3)(C)C=1C(C#N)=C(N)S2
안전
BI-0474 C화학적 특성, 용도, 생산
용도
BI-0474 is a potent KRASG12C inhibitor with an IC50 value of 7.0 nM for the GDP-KRAS::SOS1 protein-protein interaction. It exhibits good anti-proliferative activity against NCI-H358 cells carrying the G12C mutation. BI-0474 also shows good anti-tumour activity in non-small cell lung cancer xenograft models.BI-0474 준비 용품 및 원자재
원자재
준비 용품
BI-0474 공급 업체
글로벌( 23)공급 업체
| 공급자 | 전화 | 이메일 | 국가 | 제품 수 | 이점 |
|---|---|---|---|---|---|
| Hubei Chuchang Biotech Co., Ltd. | +86-18727130788 +86-18727130788 |
info@chuchangbiotech.com | China | 109 | 58 |
| Wuhan Jingkang en Biomedical Technology Co., Ltd | +8613720134139 |
orders@jknbiochem.com | China | 4692 | 58 |
| Hubei Chuchang Chemical Co., Ltd | 15623560702 |
Joy.Ren@aliyun.com | China | 144 | 58 |
| Changzhou Borl Biotechnology Co.,LTD | 13606124132;13656121842 |
luyan0021@163.com | China | 217 | 58 |
| ShangHai Caerulum Pharma Discovery Co., Ltd. | 18149758185 |
sales-cpd@caerulumpharma.com | China | 3453 | 58 |
| Shanghai Lollane Biological Technology Co.,Ltd. | 021-52996696，15000506266 15000506266 |
China | 4197 | 55 | |
| ShangHai Angti Biotechnology Co., Ltd. | 13764913901 |
info@angtibio.com | China | 4869 | 55 |
| ShangHai Biochempartner Co.,Ltd | 17754423994 17754423994 |
2853530910@QQ.com | China | 8012 | 62 |
| Shanghai Rechem science Co., Ltd. | 21-31433387 15618786686 |
sales@rechemscience.com | China | 2986 | 58 |
| DC Chemicals | 021-58447131 13564518121 |
sales@dcchemicals.com | China | 9412 | 58 |