ChemicalBook >> CAS DataBase List >>N-Butyldeoxynojirimycin

N-Butyldeoxynojirimycin

N-Butyldeoxynojirimycin structure

CAS No.: 72599-27-0

Chemical Name:: N-Butyldeoxynojirimycin

Synonyms: nb-dnj;Zavesca;OGT 918;megasat;SC-48334;Mg gross;miglusta;N-Butylmoranoline;N-BUTYLDEOXYNOJIRIMYCIN;N-BUTYL-1-DEOXYNOJIRIMYCIN

CBNumber:: CB0125257

Molecular Formula:: C10H21NO4

Molecular Weight:: 219.28

MDL Number:: MFCD00272581

MOL File:: 72599-27-0.mol

MSDS File:: SDS

Last updated:2024-11-15 19:19:13

Request For Quotation

N-Butyldeoxynojirimycin Properties

Melting point	126-127℃
alpha	D25 -15.9° (c = 0.77 in water)
Boiling point	394.7±42.0 °C(Predicted)
Density	1.234
RTECS	TN4350150
storage temp.	2-8°C
solubility	DMSO 44 mg/mL (200.66 mM) Ethanol 22 mg/mL (100.33 mM) Water 44 mg/mL (200.66 mM)
form	Powder
pka	13.72±0.70(Predicted)
color	White
Water Solubility	Soluble in water at 10mg/ml
InChI	InChI=1S/C10H21NO4/c1-2-3-4-11-5-8(13)10(15)9(14)7(11)6-12/h7-10,12-15H,2-6H2,1H3/t7-,8+,9-,10-/m1/s1
InChIKey	UQRORFVVSGFNRO-UTINFBMNSA-N
SMILES	N1(CCCC)C[C@H](O)[C@@H](O)[C@H](O)[C@H]1CO
FDA UNII	ADN3S497AZ

SAFETY

Risk and Safety Statements

Symbol(GHS)	GHS07
Signal word	Warning
Hazard statements	H315-H319
Precautionary statements	P264-P280-P302+P352-P337+P313-P305+P351+P338-P362+P364-P332+P313
WGK Germany	3
HS Code	2933399990

N-Butyldeoxynojirimycin price More Price(30)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
Sigma-Aldrich	B8299	N-Butyldeoxynojirimycin film (dried in situ)	72599-27-0	1mg	$431	2024-03-01	Buy
Sigma-Aldrich	203996	N-Butyldeoxynojirimycin, Hydrochloride	72599-27-0	10mg	$335	2022-05-15	Buy
Alfa Aesar	J66613	N-Butyldeoxynojirimycin, 98%	72599-27-0	5mg	$431.65	2024-03-01	Buy
Alfa Aesar	J66613	N-Butyldeoxynojirimycin, 98%	72599-27-0	1mg	$135	2023-06-20	Buy
Sigma-Aldrich	B8299	N-Butyldeoxynojirimycin film (dried in situ)	72599-27-0	5mg	$1600	2024-03-01	Buy

Product number	Packaging	Price	Buy
B8299	1mg	$431	Buy
203996	10mg	$335	Buy
J66613	5mg	$431.65	Buy
J66613	1mg	$135	Buy
B8299	5mg	$1600	Buy

N-Butyldeoxynojirimycin Chemical Properties,Uses,Production

Description

Miglustat is an N-alkylated iminosugar, launched as an oral treatment for mild to moderate type 1 Gaucher’s disease in adult patients for whom enzyme replacement therapy is not a therapeutic option. It is readily synthesized from D-glucose in three steps by first converting to N-butylglucamine via reductive amination with butylamine, followed by a microbial oxidation to an aminofuranose intermediate and subsequent reductive cyclization. Type 1 Gaucher’s disease is a metabolic disorder caused by the lysosomal accumulation of certain glycosphingolipids (GSLs) as a result of deficiency in their degradation. Enlargement of the liver and spleen, low blood platelet and bone lesions are among the key symptoms of this disease. Miglustat acts by inhibiting glucosylceramide synthase, a glucosyl transferase enzyme in the biosynthesis of most GSLs, which results in the lowering of GSLs to a level that can be effectively cleared. Up to 50% reduction in liver and splenocyte GSL levels are achieved in mice by long-term administration of Miglustat (600– 1800 mg/kg/day for 118 days). Miglustat, dosed at 50 and 100 mg in Gaucher patients, exhibits dose proportionate pharmacokinetics (t_max=2.5 h, t_1/2=6 to 7 h) and ＞90% oral bioavailability. Steady-state plasma levels are reached after 4–6 weeks of treatment. Miglustat is not significantly metabolized in humans and the major route of excretion is renal. In clinical trials, efficacy was demonstrated by significant reductions in liver and spleen volumes (12 and 19%, respectively) at 12 months and increase in hemoglobin and platelet count (0.91 g/dL and 13.6×10⁹/l, respectively) at 24 months. Miglustat is generally well tolerated by patients and the most common side effects are diarrhea and weight loss.

Originator

G.D. Searle (Pfizer) (US)

Uses

An alpha-glucosidase Inhibitor

Uses

Treatment of glycolipid storage diseases.

Definition

ChEBI: A hydroxypiperidine that is deoxynojirimycin in which the amino hydrogen is replaced by a butyl group.

Indications

N-butyldeoxynojirimycin is an approved drug for Niemann–Pick disease type C and Gaucher disease type 1, which are lipid storage disorders[1].

brand name

Zavesca(Actelion);Vevesca.

General Description

N-Butyldeoxynojirimycin is an alkylated product of imino sugar deoxynojirimycin.

Biological Activity

Orally active α -glucosidase I and II and ceramide-specific glycosyltransferase inhibitor. Rescues trafficking-deficient F508del-CTFR in human airway epithelial cells via inhibition of ER α -glucosidases I and II. Also has broad spectrum antiviral activity.

Biochem/physiol Actions

N-Butyldeoxynojirimycin is an inhibitor of glucosyltransferase and α-glucosidases. N-Butyldeoxynojirimycin, also known as misglustat, reduces glycolipid levels by substrate reduction therapy (SRT) and is effectively used for the treatment of glycosphingolipid lysosomal storage disorder, Gaucher disease.

References

[1] Hiroyuki Nakamura . “N-butyldeoxynojirimycin (miglustat) ameliorates pulmonary fibrosis through inhibition of nuclear translocation of Smad2/3.” Biomedicine & Pharmacotherapy 160 (2023): Article 114405.

N-Butyldeoxynojirimycin Preparation Products And Raw materials

Raw materials

Preparation Products

N-Butyldeoxynojirimycin Suppliers

Global( 137)Suppliers

Supplier	Tel	Email	Country	ProdList	Advantage
Chengdu Biopurify Phytochemicals Ltd.	+8618080483897	sales@biopurify.com	China	3772	58
Hebei Weibang Biotechnology Co., Ltd	+8615531157085	abby@weibangbio.com	China	8813	58
Hebei Mojin Biotechnology Co., Ltd	+86 13288715578 +8613288715578	sales@hbmojin.com	China	12840	58
Hebei Ganmiao New material Technology Co., LTD	+86-17332992504 +86-17332992504	sales8@hbganmiao.com	China	299	58
Shanghai Daken Advanced Materials Co.,Ltd	+86-371-66670886	info@dakenam.com	China	18781	58
Hangzhou FandaChem Co.,Ltd.	+8615858145714	FandaChem@Gmail.com	China	9215	55
Shanghai Zheyan Biotech Co., Ltd.	18017610038	zheyansh@163.com	CHINA	3619	58
career henan chemical co	+86-0371-86658258 +8613203830695	sales@coreychem.com	China	29884	58
BOC Sciences	+1-631-485-4226	inquiry@bocsci.com	United States	19553	58
Chongqing Chemdad Co., Ltd	+86-023-6139-8061 +86-86-13650506873	sales@chemdad.com	China	39894	58

Supplier	Advantage
Chengdu Biopurify Phytochemicals Ltd.	58
Hebei Weibang Biotechnology Co., Ltd	58
Hebei Mojin Biotechnology Co., Ltd	58
Hebei Ganmiao New material Technology Co., LTD	58
Shanghai Daken Advanced Materials Co.,Ltd	58
Hangzhou FandaChem Co.,Ltd.	55
Shanghai Zheyan Biotech Co., Ltd.	58
career henan chemical co	58
BOC Sciences	58
Chongqing Chemdad Co., Ltd	58

View Lastest Price from N-Butyldeoxynojirimycin manufacturers

Update time	Product	Price	Min. Order	Purity	Supply Ability	Manufacturer
2024-11-15	N-BUTYLDEOXYNOJIRIMYCIN 72599-27-0	US $1.00 / KG	1KG	99%	10 mt	Hebei Weibang Biotechnology Co., Ltd
2024-11-14	Miglustat 72599-27-0	US $38.00-139.00 / mg		99.75%	10g	TargetMol Chemicals Inc.
2024-11-14	Miglustat 72599-27-0	US $38.00-139.00 / mg		99.75%	10g	TargetMol Chemicals Inc.

N-BUTYLDEOXYNOJIRIMYCIN
72599-27-0
US $1.00 / KG
99%
Hebei Weibang Biotechnology Co., Ltd

Miglustat
72599-27-0
US $38.00-139.00 / mg
99.75%
TargetMol Chemicals Inc.

Miglustat
72599-27-0
US $38.00-139.00 / mg
99.75%
TargetMol Chemicals Inc.

N-Butyldeoxynojirimycin Spectrum

N-BUTYLDEOXYNOJIRIMYCIN(72599-27-0)MS

72599-27-0(N-Butyldeoxynojirimycin )Related Search:

2-Cyclopropyl-4-(4-fluorophenyl)-quinolyl-3-methanol Deionized water Cocamidopropyl betaine 1-Deoxynojirimycin N-Dodecyldeoxynojirimycin

N-(5-ADAMANTANE-1-YL-METHOXY)-PENTYL-DEOXYNOJIRIMYCIN N-(7-Oxa-9,9,9-trifluorononyl)deoxynojirimycin N-CYCLOHEXYLPROPYL DEOXYNOJIRIMYCIN, HYDROCHLORIDE N-(7-Oxadecyl)deoxynojirimycin CAMIGLIBOSE

N-5-Carboxypentyl-1-deoxynojirimycin N-(n-Nonyl)deoxynojirimycin N-CYCLOHEXYLPROPYL DEOXYNOJIRIMYCIN N-BUTYLDEOXYNOJIRIMYCIN, HYDROCHLORIDE glycovir

N-BUTYLDEOXYNOJIRIMYCIN

1of4

N-BUTYLDEOXYNOJIRIMYCIN N-BUTYL-1-DEOXYNOJIRIMYCIN (2R)-1-Butyl-2α-(hydroxymethyl)piperidine-3β,4α,5β-triol 1,5-(Butylimino)-1,5-dideoxy-D-glucitol 1-Butyl-2α-(hydroxymethyl)piperidine-3β,4α,5β-triol 1-Butyl-3β,4α,5β-trihydroxypiperidine-2α-methanol SC-48334 (2R,3R,4R,5S)-1-Butyl-2-(hydroxymethyl)-3,4,5-piperidinetriol N-Butylmoranoline OGT 918 Zavesca nb-dnj Miglustat, NB-DNJ, (2R,3R,4R,5S)-1-butyl-2-(hydroxymethyl)piperidine-3,4,5-triol N-(n-Butyl)-1-deoxynojirimycin min. 99% N-Butyldeoxynojirimycin, Hydrochloride - CAS 72599-27-0 - Calbiochem Mg gross N-BUTYLDEOXYNOJIRIMYCIN;SC-48334;NB-DNJ;OGT-918 MIGLUSTAT;N-BUTYLDEOXYNOJIRIMYCIN;NB-DNJ;OGT918 Miglustat (N-Butyldeoxynojirimycin) N-(n-Butyl)-1-deoxynojirimycin 3,4,5-Piperidinetriol, 1-butyl-2-(hydroxymethyl)-, (2R,3R,4R,5S)- Hot Sale 3, 4, 5-Piperidinetriol, 1-Butyl-2- (hydroxymethyl) -, (2R, 3R, 4R, 5S) N-BUTYLDEOXYNOJIRIMYCIN Miglustat hydrochloride salt MiglustatQ: What is Miglustat Q: What is the CAS Number of Miglustat Q: What is the storage condition of Miglustat oral,Miglustat,Inhibitor,inhibit,ceramide glucosyltransferase,OGT-918,OGT 918,type I gaucher disease miglusta megasat 72599-27-0 C10H22NO4 Glucosidase, alpha- D to K Enzyme Inhibitors Enzymes, Inhibitors, and Substrates Enzyme Inhibitors by Enzyme Biochemicals and Reagents BioChemical API