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N-BUTYLDEOXYNOJIRIMYCIN, HYDROCHLORIDE

N-BUTYLDEOXYNOJIRIMYCIN, HYDROCHLORIDE structure

CAS No.: 210110-90-0

Chemical Name:: N-BUTYLDEOXYNOJIRIMYCIN, HYDROCHLORIDE

Synonyms: NB-DNJ, HCL;Miglustat HCl;(2R,3R,4R,5S)-;N-BUTYL-DNJ, HCL;NB-DNJ hydrochloride;OGT918 hydrochloride;Zavesca hydrochloride;Miglustat HCl (OGT-918;Miglustat, Hydrochloride;N-BUTYLDEOXYNOJIRIMYCIN HCL

CBNumber:: CB7328886

Molecular Formula:: C10H22ClNO4

Molecular Weight:: 255.74

MDL Number:: MFCD00269940

MOL File:: 210110-90-0.mol

Last updated:2024-11-19 23:02:33

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N-BUTYLDEOXYNOJIRIMYCIN, HYDROCHLORIDE Properties

Melting point	169-172°C
storage temp.	Inert atmosphere,Room Temperature
solubility	Soluble in DMSO (up to 20 mg/ml) or in Water (up to 20 mg/ml)
form	White to off-white solid.
color	White
Stability	Stable for 1 year from date of purchase as supplied. Solutions in DMSO or distilled water may be stored at -20°C for up to 1 month.

SAFETY

Risk and Safety Statements

Symbol(GHS)	GHS07
Signal word	Warning
Hazard statements	H302-H315-H319-H335
Precautionary statements	P261-P305+P351+P338
Hazard Codes	Xi
HS Code	2933399990

N-BUTYLDEOXYNOJIRIMYCIN, HYDROCHLORIDE price More Price(25)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
Cayman Chemical	21065	N-Butyldeoxynojirimycin (hydrochloride) ≥98%	210110-90-0	1mg	$37	2024-03-01	Buy
Cayman Chemical	21065	N-Butyldeoxynojirimycin (hydrochloride) ≥98%	210110-90-0	5mg	$98	2024-03-01	Buy
Cayman Chemical	21065	N-Butyldeoxynojirimycin (hydrochloride) ≥98%	210110-90-0	10mg	$161	2024-03-01	Buy
Cayman Chemical	21065	N-Butyldeoxynojirimycin (hydrochloride) ≥98%	210110-90-0	25mg	$353	2024-03-01	Buy
Tocris	3117	Miglustathydrochloride	210110-90-0	10	$227	2021-12-16	Buy

Product number	Packaging	Price	Buy
21065	1mg	$37	Buy
21065	5mg	$98	Buy
21065	10mg	$161	Buy
21065	25mg	$353	Buy
3117	10	$227	Buy

N-BUTYLDEOXYNOJIRIMYCIN, HYDROCHLORIDE Chemical Properties,Uses,Production

Description

Miglustat HCl (210110-90-0) is an orally active ceramide-specific glycosyltransferase and α-glucosidase I and II inhibitor.1 Rescues trafficking-deficient F508del-CFTR in human airway epithelial cells via inhibition of ER α-glucosidases I and II.2 Pharmacological chaperone for glucocerebrosidase degradation.3 Clinically useful agent for Gaucher disease type 1.4 Stabilizes neurological disorders in Niemann-Pick disease type C.5

Chemical Properties

White Crystals

Uses

An inhibitor of a-glucosidase 1 as well as being an inhibitor of HIV cytopathicity. N-Butyldeoxynojirimycin has recently been used to retard lipid storage in the central nervous system of an animal m odel of Tay-Sachs disease. 1-Deoxynojirimycin derivatives as selective inhibitors of glucosylceramide metabolism in man.

storage

Desiccate at -20°C

References

1) Platt et al. (1994), N-butyldeoxynojirimycin is a novel inhibitor if glycolipid biosynthesis; J. Biol. Chem., 269 8362 2) Noel et al. (2008), Parallel improvement of sodium and chloride transport defects by miglustat (n-butyldeoxynojyrimicin) in cystic fibrosis; J. Pharmacol. Exp. Ther., 325 1016 3) Abian et al. (2011), Therapeutic strategies for Gaucher disease: miglustat (NB-DNJ) as a pharmacological chaperone for glucocerebrosidase and the different thermostability of velaglucerase alfa and imiglucerase; Mol. Pharm., 8 2390 4) Serratrice et al. (2015), Switching from imiglucerase to miglustat for the treatment of French patients with Gaucher disease type 1: a case series; J. Med. Case Rep., 9 146 5) Karimzadeh (2013), Effects of miglustat on stabilization of neurological disorder in niemann-pick disease type C: Iranian pediatric case series; J. Child Neurol., 28 1599

N-BUTYLDEOXYNOJIRIMYCIN, HYDROCHLORIDE Preparation Products And Raw materials

Raw materials

Preparation Products

N-BUTYLDEOXYNOJIRIMYCIN, HYDROCHLORIDE Suppliers

Global( 87)Suppliers

Supplier	Tel	Email	Country	ProdList	Advantage
BOC Sciences	+1-631-485-4226	inquiry@bocsci.com	United States	19553	58
AFINE CHEMICALS LIMITED	+86-0571-85134551	sales@afinechem.com	China	15352	58
NewCan Biotech Limited	+86-0571-86912261 +8613735419629	sales@newcanbio.com	China	9983	58
InvivoChem	+1-708-310-1919 +1-13798911105	sales@invivochem.cn	United States	6391	58
Nantong HI-FUTURE Biology Co., Ltd.	+undefined18051384581	sales@chemhifuture.com	China	3135	58
TargetMol Chemicals Inc.		support@targetmol.com	United States	38631	58
Wuhan Topule Biopharmaceutical Co., Ltd	+8618327326525	masar@topule.com	China	8467	58
LEAPCHEM CO., LTD.	+86-852-30606658	market18@leapchem.com	China	43340	58
Aladdin Scientific	+1-+1(833)-552-7181	sales@aladdinsci.com	United States	57505	58
Suzhou ARTK Medchem Co., Ltd.	+86-512-68323658 +86-18168183658	sales1@artkmedchem.com	China	39004	58

Supplier	Advantage
BOC Sciences	58
AFINE CHEMICALS LIMITED	58
NewCan Biotech Limited	58
InvivoChem	58
Nantong HI-FUTURE Biology Co., Ltd.	58
TargetMol Chemicals Inc.	58
Wuhan Topule Biopharmaceutical Co., Ltd	58
LEAPCHEM CO., LTD.	58
Aladdin Scientific	58
Suzhou ARTK Medchem Co., Ltd.	58

View Lastest Price from N-BUTYLDEOXYNOJIRIMYCIN, HYDROCHLORIDE manufacturers

Image	Update time	Product	Price	Min. Order	Purity	Supply Ability	Manufacturer
	2024-11-19	Miglustat hydrochloride 210110-90-0	US $34.00-80.00 / mg		99.61%	10g	TargetMol Chemicals Inc.
	2024-04-25	N-Butyldeoxynojirimycin Hydrochloride 210110-90-0	US $10.00 / kg	1kg	99.912%	10ton	Ouhuang Engineering Materials (Hubei) Co., Ltd

Miglustat hydrochloride
210110-90-0
US $34.00-80.00 / mg
99.61%
TargetMol Chemicals Inc.

N-Butyldeoxynojirimycin Hydrochloride
210110-90-0
US $10.00 / kg
99.912%
Ouhuang Engineering Materials (Hubei) Co., Ltd

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Miglustat, Hydrochloride (2R,3R,4R,5S)-1-Butyl-2-(hydroxymethyl)-,3,4,5-Piperidinetriol Hydrochloride N-BUTYLDEOXYNOJIRIMYCIN HCL N-BUTYLDEOXYNOJIRIMYCIN, HYDROCHLORIDE N-BUTYL-DNJ, HCL NB-DNJ, HCL N-(N-BUTYL)DEOXYNOJIRIMYCIN, HYDROCHLORIDE (2R,3R,4R,5S)-1-Butyl-2-(hydroxymethyl)piperidine-3,4,5-triol hydrochloride Miglustat hydrochloride, N-(n-Butyl)deoxynojirimycin hydrochloride (2R,3R,4R,5S)- Miglustat HCl, NB-DNJ HCl, (2R,3R,4R,5S)-1-Butyl-2-(hydroxymethyl)piperidine-3,4,5-triol N-(n-Butyl)-1-deoxynojirimycin hydrochloride min. 99% Miglustat HCl (2R,3R,4R,5S)-1-butyl-2-(hydroxymethyl)piperidine-3,4,5-triol NB-DNJ hydrochloride N-BUTYLDEOXYNOJIRIMYCIN; HYDROCHLORIDE;NB-DNJ HYDROCHLORIDE;OGT918 HYDROCHLORIDE;ZAVESCA HYDROCHLORIDE OGT918 hydrochloride Zavesca hydrochloride N-(n-Butyl)-1-deoxynojirimycin hydrochloride Miglustat hydrochloride(N-Butyldeoxynojirimycin, Hydrochloride) Miglustat HCl (OGT-918 N-Butyldeoxynojirimycin,OGT-918,type I gaucher disease,Miglustat,Miglustat hydrochloride,oral,Glucosylceramide Synthase (GCS),OGT918,ceramide glucosyltransferase,NB-DNJ,Inhibitor,inhibit,OGT 918 Miglustat hydrochloride, 10 mM in DMSO 210110-90-0 C10H21NO4HCl Glycosidase Inhibitors Intermediates & Fine Chemicals Pharmaceuticals All Inhibitors