3-Butylidenephthalide
- CAS No.
- 551-08-6
- Chemical Name:
- 3-Butylidenephthalide
- Synonyms
- 3-BUTYLIDENEPHTHALIDE;Bdph;BUTYLIDENE PHTHALIDE;3-butylidene-phthalid;3-Butylideneisobenzofuran-1(3H)-one;FEMA 3333;Ai3-37306;NSC 325307;Einecs 208-991-3;Butenylphthalide
- CBNumber:
- CB0173298
- Molecular Formula:
- C12H12O2
- Molecular Weight:
- 188.22
- MDL Number:
- MFCD00047319
- MOL File:
- 551-08-6.mol
- MSDS File:
- SDS
| Melting point | 82.5°C |
|---|---|
| Boiling point | 139-142 °C/5 mmHg (lit.) |
| Density | 1.103 g/mL at 25 °C (lit.) |
| FEMA | 3333 | 3-BUTYLIDENEPHTHALIDE |
| refractive index |
n |
| Flash point | >230 °F |
| storage temp. | Refrigerator |
| solubility | Chloroform (Slightly), Ethyl Acetate (Slightly) |
| form | Oil |
| color | Colourless to Yellow |
| Odor | at 10.00 % in dipropylene glycol. herbal lovage celery |
| Odor Type | herbal |
| biological source | synthetic |
| JECFA Number | 1170 |
| BRN | 5145 |
| InChIKey | WMBOCUXXNSOQHM-FLIBITNWSA-N |
| LogP | 3.72 |
| Substances Added to Food (formerly EAFUS) | 3-BUTYLIDENEPHTHALIDE |
| CAS DataBase Reference | 551-08-6(CAS DataBase Reference) |
| FDA UNII | S9178G4B3F |
| EPA Substance Registry System | 1(3H)-Isobenzofuranone, 3-butylidene- (551-08-6) |
| UNSPSC Code | 12164502 |
| NACRES | NA.21 |
3-Butylidenephthalide price More Price(24)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Alfa Aesar | A10353 | n-Butylidenephthalide, (E)+(Z), 95% | 551-08-6 | 10g | $31.65 | 2024-03-01 | Buy |
| Alfa Aesar | A10353 | n-Butylidenephthalide, (E)+(Z), 95% | 551-08-6 | 50g | $90.65 | 2024-03-01 | Buy |
| Alfa Aesar | A10353 | n-Butylidenephthalide, (E)+(Z), 95% | 551-08-6 | 250g | $342 | 2023-06-20 | Buy |
| Usbiological | 299818 | 3-Butylidenephthalide | 551-08-6 | 20mg | $297 | 2021-12-16 | Buy |
| TRC | B692250 | 3-ButylidenePhthalide(CisTransmixture) | 551-08-6 | 25g | $425 | 2021-12-16 | Buy |
3-Butylidenephthalide Chemical Properties,Uses,Production
Description
N-Butylidenephthalide is a phthalide derivative useful for control of sensation disorder and olfaction disorder. It is a bioactive phthalide compound of Chuanxiong rhizoma, a Chinese herbal medicine used for treating headache obtained from the root of Ligusticum chuanxiong Hort. It has found that it can regulate tumor stem cell genes EZH2/AXL and reduced its migration and invasion in glioblastoma. Moreover, it can induce apoptosis in the A549 human lung adenocarcinoma cell line by coupled down-regulation of AP-2a and telomerase activity. Therefore, it is a potential cancer chemotherapy drug. Moreover, It can also exhibit protection against neurotoxicity through regulation of tryptophan 2, 3 dioxygenase in spinocerebellar ataxia type 3. Finally, it has certain antiplatelet effect.
Reference
- Lin, Po Cheng, et al. "Orphan nuclear receptor, Nurr‐77 was a possible target gene of butylidenephthalide chemotherapy on glioblastoma multiform brain tumor." Journal of Neurochemistry 106.3(2010):1017-1026.
- Rajamani, K, et al. "n-Butylidenephthalide exhibits protection against neurotoxicity through regulation of tryptophan 2, 3 dioxygenase in spinocerebellar ataxia type 3." Neuropharmacology 117(2017):434-446.
- Teng, C. M., et al. "Antiplatelet effect of butylidenephthalide." BBA General Subjects 924.3(1987):375-382.
Chemical Properties
3-Butylidenephthalide has a pervasive warm spicy aroma.
Occurrence
Reported as occurring naturally in the fruits and roots of Ligusticum acutilobum and lovage (Levisticum officinale) seeds, roots and leaves.
Uses
3-Butylidenephthalide is a phthalide derivative useful for control of sensation disorder and olfaction disorder.
Definition
ChEBI: A gamma-lactone that is phthalide substituted by a butylidene group at position 3. Isolated from Ligusticum porteri, it exhibits hypoglycemic activity.
Taste threshold values
Taste characteristics at 15 ppm: celery, green, vegetable-like with a herbal nuance.
General Description
3-Butylidenephthalide is a bioactive phthalide compound of Chuanxiong rhizoma, a Chinese herbal medicine used for treating headache obtained from the root of Ligusticum chuanxiong Hort.
Cytotoxicity
The anti-proliferative effects of 3-Butylidenephthalide (n-Butylidenephthalide; BP) on cells from GBM, neuroblastoma, lung cancer, melanoma, teratoma, leukemia, breast cancer and hepatocellular carcinoma, as well as from normal fibroblast and vascular endothelial cells, were determined. The IC50 values of BP after a 48 h incubation with tumor cell lines (IC50: 15–67 μg/mL) were significantly lower than the values for normal fibroblast cells (IC50: >?100 μg/mL, p < 0.0001) or carmustine (BCNU)-treated tumor cells (IC50: 40 ～ 100 μg/mL, p < 0.001; Table 1). In the two normal cell types, vascular endothelial cells (IC50 = 25.0 ± 2.0 μg/mL) were more sensitive to BP than fibroblast cells (IC50 > 100 μg/mL) (p < 0.0001). These experiments showed that BP could induce high cytotoxicity against brain and other tumour cells but only low or no cytotoxicity against normal fibroblast cells.
Safety Profile
Moderately toxic by ingestion. A skin irritant. When heated to decomposition it emits acrid smoke and irritating fumes.
target
Nrf2 | TNF-α | NO | IL Receptor
3-Butylidenephthalide Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Shijiazhuang Dowell Chemical Co.,Ltd | +86-0311-89805679 +8613463963265 | sell@dowechem.com | China | 76 | 58 |
| career henan chemical co | +86-0371-86658258 +8613203830695 | sales@coreychem.com | China | 29879 | 58 |
| Hebei Weibang Biotechnology Co., Ltd | +8615531157085 | abby@weibangbio.com | China | 8806 | 58 |
| Hebei Mujin Biotechnology Co.,Ltd | +86 13288715578 +8613288715578 | sales@hbmojin.com | China | 12831 | 58 |
| Hebei Zhuanglai Chemical Trading Co Ltd | +86-16264648883 +86-16264648883 | niki@zlchemi.com | China | 3712 | 58 |
| Henan Tianfu Chemical Co.,Ltd. | +86-0371-55170693 +86-19937530512 | info@tianfuchem.com | China | 21634 | 55 |
| Shanghai Zheyan Biotech Co., Ltd. | 18017610038 | zheyansh@163.com | CHINA | 3619 | 58 |
| Chengdu Greenpure Biopharma CO.,Ltd | 18283602253; +8618283602253 | jancyzheng@gcgreenpure.com | China | 953 | 58 |
| Shenzhen Nexconn Pharmatechs Ltd | +86-755-89396905 +86-15013857715 | admin@nexconn.com | China | 10311 | 58 |
| Chengdu Biopurify Phytochemicals Ltd. | +8618080483897 | sales@biopurify.com | China | 3772 | 58 |
View Lastest Price from 3-Butylidenephthalide manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2025-01-24 | 3-Butylidene phthalide
551-08-6
|
US $45.00 / kg | 1kg | 99% | 20 tons | Hebei Zhuanglai Chemical Trading Co Ltd | |
 |
2025-01-23 | 3-Butylidene phthalide
551-08-6
|
US $0.00-0.00 / kg | 1kg | 99% | 500kg/month | Shijiazhuang Dowell Chemical Co.,Ltd | |
 |
2024-11-19 | 3-Butylidenephthalide
551-08-6
|
US $31.00-76.00 / mg | 90.76% | 10g | TargetMol Chemicals Inc. |
-
- 3-Butylidene phthalide
551-08-6
- US $45.00 / kg
- 99%
- Hebei Zhuanglai Chemical Trading Co Ltd
-
- 3-Butylidene phthalide
551-08-6
- US $0.00-0.00 / kg
- 99%
- Shijiazhuang Dowell Chemical Co.,Ltd
-
- 3-Butylidenephthalide
551-08-6
- US $31.00-76.00 / mg
- 90.76%
- TargetMol Chemicals Inc.