Metaxalone
- CAS No.
- 1665-48-1
- Chemical Name:
- Metaxalone
- Synonyms
- Zorane;AHR-438;Skelaxi;NSC2351;cl39,148;SKELAXIN;NSC 2351;NSC-2351;CL 39,148;Metaxalon
- CBNumber:
- CB0175959
- Molecular Formula:
- C12H15NO3
- Molecular Weight:
- 221.25
- MDL Number:
- MFCD00867700
- MOL File:
- 1665-48-1.mol
| Melting point | 121-1230C |
|---|---|
| Boiling point | 225°C/1.5mmHg(lit.) |
| Density | 1.1514 (rough estimate) |
| refractive index | 1.5200 (estimate) |
| Flash point | 9 °C |
| storage temp. | Sealed in dry,Store in freezer, under -20°C |
| solubility | DMSO: ≥2mg/mL (warmed to 60 °C) |
| form | powder |
| pka | 12.26±0.40(Predicted) |
| color | white to tan |
| BCS Class | 2 |
| InChIKey | IMWZZHHPURKASS-UHFFFAOYSA-N |
| CAS DataBase Reference | 1665-48-1(CAS DataBase Reference) |
| EWG's Food Scores | 1 |
| FDA UNII | 1NMA9J598Y |
| NIST Chemistry Reference | Metaxalone(1665-48-1) |
| EPA Substance Registry System | 2-Oxazolidinone, 5-[(3,5-dimethylphenoxy)methyl]- (1665-48-1) |
| UNSPSC Code | 41116107 |
| NACRES | NA.77 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H302 | |||||||||
| Precautionary statements | P301+P312+P330 | |||||||||
| Hazard Codes | F,T | |||||||||
| Risk Statements | 11-23/24/25-39/23/24/25 | |||||||||
| Safety Statements | 7-16-36/37-45 | |||||||||
| RIDADR | UN1230 - class 3 - PG 2 - Methanol, solution | |||||||||
| WGK Germany | 3 | |||||||||
| RTECS | RQ3850000 | |||||||||
| HS Code | 2934990002 | |||||||||
| Hazardous Substances Data | 1665-48-1(Hazardous Substances Data) | |||||||||
| NFPA 704 |
|
Metaxalone price More Price(46)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | PHR3036 | Metaxalone pharmaceutical secondary standard, certified reference material | 1665-48-1 | 500MG | $173 | 2024-03-01 | Buy |
| Sigma-Aldrich | M-074 | Metaxalone solution 1.0?mg/mL in methanol, ampule of 1?mL, certified reference material, Cerilliant? | 1665-48-1 | 1mL | $166 | 2024-03-01 | Buy |
| Sigma-Aldrich | 1396149 | Metaxalone United States Pharmacopeia (USP) Reference Standard | 1665-48-1 | 200mg | $174.4 | 2024-03-01 | Buy |
| Sigma-Aldrich | M-143 | Metaxalone-D6 solution 100?μg/mL in methanol, ampule of 1?mL, certified reference material, Cerilliant? | 1665-48-1 | 1mL | $124 | 2022-05-15 | Buy |
| TCI Chemical | M2578 | Metaxalone >98.0%(GC) | 1665-48-1 | 1g | $39 | 2024-03-01 | Buy |
Metaxalone Chemical Properties,Uses,Production
Chemical Properties
White Crystalline Solid
Originator
Skelaxin,Robins,US,1962
Uses
For the treatment of painful peripheral musculoskeletal conditions and spasticity from upper motor neuron syndromes.
Uses
muscle relaxant (skeletal)
Uses
It is a muscle relaxant used to relax muscles and relieve pain
Uses
Metaxalone is a skeletal muscle relaxant that has applications in reducing muscle spasm, limitations in normal motion, and pain caused by musculoskeletal conditions. It is commonly used in combination with analgesics to address low back pain. The molecular or cellular actions of metaxalone is not known.[Cayman Chemical]
Definition
ChEBI: Metaxalone is an aromatic ether.
Manufacturing Process
Urea (118 g, 1.96 mols) was added to 192 g (0.98 mol) of 3-(3',5'- dimethylphenoxy)-1,2-propane-diol which had previously been heated to 150°C. The reaction mixture was then heated rapidly to 195° to 200°C and maintained at this temperature for 5 hours with constant stirring. The resulting mixture was partitioned between water and ethyl acetate and the ethyl acetate layer was dried over sodium sulfate and concentrated. The residue was distilled in vacuo and the fraction boiling at 220° to 225°C/1.5 mm was collected. Yield, 172 g (79%). The distillate was crystallized from dry ethyl acetate; MP, 121.5° to 123°C.
Therapeutic Function
Muscle relaxant
Biological Activity
Metaxalone is a muscle relaxant. The mechanism of action of metaxalone in humans is not fully understood. It was suggested th at it acts through general central nervous system depression. ', 'Metaxalone is effective to relieve pain due to acute skeletal muscle pain caused due to musculoskeletal conditions and sprains.
Metaxalone Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Shaanxi Cuikang Pharmaceutical Technology Co., Ltd | +8618829768577 | gao490372054@gamil.com | China | 1249 | 58 |
| Shaanxi Cuikang Pharmaceutical Technology Co., Ltd | +8618791163155 | 18791163155@163.com | China | 3558 | 58 |
| Shandong Liteng Biotechnology Co. , Ltd. | +86-18663721413 +86-15552573001 | rosy@litengpharm.com | China | 3293 | 58 |
| career henan chemical co | +86-0371-86658258 +8613203830695 | sales@coreychem.com | China | 29858 | 58 |
| Alchem Pharmtech,Inc. | 8485655694 | sales@alchempharmtech.com | United States | 63687 | 58 |
| TargetMol Chemicals Inc. | +1-781-999-5354 +1-00000000000 | marketing@targetmol.com | United States | 32219 | 58 |
| Hefei TNJ Chemical Industry Co.,Ltd. | +86-0551-65418671 +8618949823763 | sales@tnjchem.com | China | 34563 | 58 |
| HANGZHOU CLAP TECHNOLOGY CO.,LTD | 86-571-88216897,88216896 13588875226 | sales@hzclap.com | CHINA | 6312 | 58 |
| Xi'an MC Biotech, Co., Ltd. | 029-89275612 +8618991951683 | mcbio_sales@163.com | China | 2251 | 58 |
| AFINE CHEMICALS LIMITED | +86-0571-85134551 | sales@afinechem.com | China | 15417 | 58 |
View Lastest Price from Metaxalone manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2025-03-07 | Metaxalone
1665-48-1
|
US $0.00 / kg | 1kg | 99% | 10000KGS | Shaanxi Dideu New Materials Co. Ltd | |
 |
2024-11-19 | Metaxalone
1665-48-1
|
US $39.00-155.00 / mg | 99.95% | 10g | TargetMol Chemicals Inc. | ||
 |
2021-08-12 | Metaxalone
1665-48-1
|
US $15.00-10.00 / KG | 1KG | 99%+ HPLC | Monthly supply of 1 ton | Zhuozhou Wenxi import and Export Co., Ltd |
-
- Metaxalone
1665-48-1
- US $0.00 / kg
- 99%
- Shaanxi Dideu New Materials Co. Ltd
-
- Metaxalone
1665-48-1
- US $39.00-155.00 / mg
- 99.95%
- TargetMol Chemicals Inc.
-
- Metaxalone
1665-48-1
- US $15.00-10.00 / KG
- 99%+ HPLC
- Zhuozhou Wenxi import and Export Co., Ltd
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