Metaxalone synthesis
- Product Name:Metaxalone
- CAS Number:1665-48-1
- Molecular formula:C12H15NO3
- Molecular Weight:221.25
105-67-9
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1665-48-1
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Yield:1665-48-1 97%
Reaction Conditions:
with potassium hydroxide;4-methyl-2-pentanone at 0 - 120; for 3 - 4 h;
Steps:
1 Preparation of Metaxalone
3,5 dimethyl phenol or m-Xylenol (190 kg), Triglycidyl isocyanurate (150 kg), MIBK (500.0 Lt) and Potassium Hydroxide (7.5 kg) were charged to a reactor at room temperature. The temperature of the mixture was raised to 115-120° C. and thereafter the reaction mixture was agitated at this temperature for 3-4 hrs till the completion of the reaction. The reaction mixture was cooled to 0-5° C. and the precipitated solid was centrifuged and dried to give 270 kg (of Metaxalone) having purity of between 95-96%, as an off-white solid. 150 kg of Metaxalone, thus obtained was dissolved in chloroform (600 lit) by heating to 35-40° C., to which was added activated charcoal (7.5 kg) and the mixture was refluxed for 30 min. The mixture was filtered and filtrate was concentrated to give product having purity between 97-99%.
References:
US2007/185177,2007,A1 Location in patent:Page/Page column 8
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1665-48-1
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