ChemicalBook CAS DataBase List Methyl salicylate

Methyl salicylate synthesis

15synthesis methods

Product Name:Methyl salicylate
CAS Number:119-36-8
Molecular formula:C8H8O3
Molecular Weight:152.15

Methyl salicylate can be produced by esterifying salicylic acid with methanol. Commercial methyl salicylate is now synthesized, but in the past, it was commonly distilled from the twigs of Betula lenta (sweet birch) and Gaultheria procumbens (eastern teaberry or winter green).

67-56-1 Synthesis

67-56-1
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69-72-7 Synthesis

69-72-7
1238 suppliers
$5.00/10g

119-36-8
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$5.00/10g

Yield:119-36-8 98%

Reaction Conditions:

with sulfuric acid for 20 h;Reflux;

Steps:

2.1

H₂SO₄(4.0 mL, 74.63 mmol) was added to a solution of salicylic acid (5.0 g, 36.20 mmol) in MeOH (60 mL). The reaction mixture was refluxed for 20 h, allowed to reach r.t., poured into H₂O (100 mL) and extracted with CH₂Cl₂(120 mL). The organic layer was dried over Na₂SO₄(anhydrous), filtered and concentrated. The crude residue was flash chromatographed on SiO₂(5% EtOAc/hexanes) to furnish 5.44 g of methyl 2-hydroxybenzoate (colourless oil, yield: 98%).¹H NMR (CDCl₃, 250 MHz) δ ppm: 10.75 (s, 1H), 7.84 (dt, J₁=6.6 Hz, J₂=8.2 Hz, 1H), 7.45 (m, 1H), 6.98 (d, J=8.2 Hz, 1H), 6.87 (m, 1H), 3.95 (s, 3H).

References:

US2012/149769,2012,A1 Location in patent:Page/Page column 21-22

374538-03-1
207 suppliers
$14.00/1g

119-36-8
998 suppliers
$5.00/10g

References

6938-51-8
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119-36-8
998 suppliers
$5.00/10g

References

74-87-3
206 suppliers
$18.50/48622

54-21-7 Synthesis

54-21-7
522 suppliers
$5.00/100g

119-36-8
998 suppliers
$5.00/10g

References

30414-57-4
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119-36-8
998 suppliers
$5.00/10g

References

Methyl salicylate Related Search:

3-Aminophenol Methyl dihydrojasmonate Phenyl salicylate Acetylsalicylic acid Phenol Red 2-Aminophenol Methyl acetate Methyl propiolate Sodium salicylate Salicylic acid