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Alpha-D-Lactose monohydrate

Alpha-D-Lactose monohydrate structure

CAS No.: 5989-81-1

Chemical Name:: Alpha-D-Lactose monohydrate

Synonyms: LACTOSE MONOHYDRATE;α-Lactose;MILK SUGAR;ALPHA-LACTOSE MONOHYDRATE;ALPHA-D-LACTOSE;α-D-Lactose monohydrate;A-LACTOSE;Pharmatose 150M;ALPHA-LACTOSE MONOHY;A-LACTOSE MONOHYDRATE

CBNumber:: CB0177832

Molecular Formula:: C12H24O12

Molecular Weight:: 360.31

MDL Number:: MFCD00150747

MOL File:: 5989-81-1.mol

MSDS File:: SDS

Last updated:2025-01-27 09:38:02

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Alpha-D-Lactose monohydrate Properties

Melting point	219 °C
Boiling point	412.35°C (rough estimate)
alpha	[α]D20+52.2～+52.8°
Density	1,53 g/cm³
RTECS	OD9625000
refractive index	1.6480 (estimate)
storage temp.	Inert atmosphere,Room Temperature
solubility	H2O: soluble1M, clear, colorless
form	Solid
color	White to Off-White
PH	pH (50g/l, 25℃) : 4.0～6.0
biological source	bovine milk
Water Solubility	Soluble in water.
Stability	Hygroscopic
InChIKey	WSVLPVUVIUVCRA-KPKNDVKVSA-N
CAS DataBase Reference	5989-81-1(CAS DataBase Reference)
EWG's Food Scores	1
FDA UNII	EWQ57Q8I5X
EPA Substance Registry System	.alpha.-D-Glucopyranose, 4-O-.beta.-D-galactopyranosyl-, hydrate (1:1) (5989-81-1)
UNSPSC Code	85151701
NACRES	NA.75

SAFETY

Risk and Safety Statements

Hazard Codes

Risk Statements

40-36/37/38

Safety Statements

24/25-36-26

WGK Germany

TSCA

Yes

HS Code

17021100

NFPA 704

	1
1		0

Alpha-D-Lactose monohydrate price More Price(26)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
Sigma-Aldrich	L2643	α-Lactose monohydrate suitable for cell culture, BioReagent	5989-81-1	5kg	$163	2024-03-01	Buy
Sigma-Aldrich	47287-U	Lactose Monohydrate analyticalstandard	5989-81-1	1kit	$24.8	2024-03-01	Buy
Alfa Aesar	A11074	alpha-D-Lactose monohydrate	5989-81-1	250g	$23.65	2024-03-01	Buy
Alfa Aesar	A11074	alpha-D-Lactose monohydrate	5989-81-1	1000g	$56.65	2024-03-01	Buy
Alfa Aesar	036218	alpha-D-Lactose monohydrate ACS	5989-81-1	500g	$46.3	2023-06-20	Buy

Product number	Packaging	Price	Buy
L2643	5kg	$163	Buy
47287-U	1kit	$24.8	Buy
A11074	250g	$23.65	Buy
A11074	1000g	$56.65	Buy
036218	500g	$46.3	Buy

Alpha-D-Lactose monohydrate Chemical Properties,Uses,Production

Chemical Properties

Lactose occurs as white to off-white crystalline particles or powder. It is odorless and slightly sweet-tasting. Spray-dried directcompression grades of lactose are generally composed of 80–90% specially prepared pure a-lactose monohydrate along with 10–20% of amorphous lactose.

Chemical Properties

White powder

Uses

alpha-D-Lactose monohydrate is used as a carrier and stabiliser of aromas, pharmaceutical products, Food industry.

Definition

A sugar that occurs in many plants. It is extracted commercially from sugar cane and sugar beet. Sucrose is a disaccharide formed from a glucose unit and a fructose unit. It is hydrolyzed to a mixture of fructose and glucose by the enzyme invertase. Since this mixture has a different optical rotation (levorotatory) than the original sucrose, the mixture is called invert sugar.

Production Methods

A suspension of a-lactose monohydrate crystals in a lactose solution is atomized and dried in a spray drier. Approximately 10–20% of the total amount of lactose is in solution and the remaining 80–90% is present in the crystalline form. The spray-drying process predominantly produces spherical particles. The compactibility of the material and its flow characteristics are a function of the primary particle size of the lactose monohydrate and the amount of amorphous lactose.

Pharmaceutical Applications

Spray-dried lactose is widely used as a binder, filler-binder, and flow aid in direct compression tableting.

Biochem/physiol Actions

alpha-Lactose is the primary sugar present in milk and the main energy source to a newborn mammalian through its mother′s milk. It is digested by the intestinal lactase (EC 3.2.1.108), an enzyme expressed in newborns. The enzyme′s activity declines following weaning which can lead to lactose intolerance in adult mammals.

Safety

Lactose is widely used in pharmaceutical formulations as a diluent in oral capsule and tablet formulations. It may also be used in intravenous injections.
Adverse reactions to lactose are largely due to lactose intolerance, which occurs in individuals with a deficiency of the enzyme lactase.

storage

Spray-dried lactose should be stored in a well-closed container in a cool, dry place.

Incompatibilities

Lactose is a reducing sugar. The amorphous lactose, which is the most reactive form of lactose present in spray-dried lactose, will interact more readily than conventional crystalline grades. Typical reactions include the Maillard reaction with either primary or secondary amines.

Alpha-D-Lactose monohydrate Preparation Products And Raw materials

Raw materials

Preparation Products

Alpha-D-Lactose monohydrate Suppliers

Global( 320)Suppliers

Supplier	Tel	Email	Country	ProdList	Advantage
Hebei Chuanghai Biotechnology Co., Ltd	+8615531157085	abby@chuanghaibio.com	China	8808	58
Henan Fengda Chemical Co., Ltd	+86-371-86557731 +86-13613820652	info@fdachem.com	China	20235	58
Capot Chemical Co.,Ltd.	+86-（0）57185586718 +86-13336195806	sales@capot.com	China	29730	60
Shanghai Daken Advanced Materials Co.,Ltd	+86-371-+86-371-66670886	info@dakenam.com	China	19809	58
Henan Tianfu Chemical Co.,Ltd.	+86-0371-55170693 +86-19937530512	info@tianfuchem.com	China	21628	55
Hubei Jusheng Technology Co.,Ltd.	18871490254	linda@hubeijusheng.com	CHINA	28172	58
Shaanxi Pioneer Biotech Co., Ltd .	+8613259417953	sales@pioneerbiotech.com	China	1287	58
BOC Sciences	+1-631-485-4226	inquiry@bocsci.com	United States	19552	58
career henan chemical co	+86-0371-86658258 +8613203830695	factory@coreychem.com	China	29808	58
Hebei Mujin Biotechnology Co.,Ltd	+86 13288715578 +8613288715578	sales@hbmojin.com	China	12809	58

Supplier	Advantage
Hebei Chuanghai Biotechnology Co., Ltd	58
Henan Fengda Chemical Co., Ltd	58
Capot Chemical Co.,Ltd.	60
Shanghai Daken Advanced Materials Co.,Ltd	58
Henan Tianfu Chemical Co.,Ltd.	55
Hubei Jusheng Technology Co.,Ltd.	58
Shaanxi Pioneer Biotech Co., Ltd .	58
BOC Sciences	58
career henan chemical co	58
Hebei Mujin Biotechnology Co.,Ltd	58

View Lastest Price from Alpha-D-Lactose monohydrate manufacturers

Update time	Product	Price	Min. Order	Purity	Supply Ability	Manufacturer
2025-04-24	Alpha-D-Lactose monohydrate 5989-81-1	US $3.00 / kg	1kg	0.99	1000	Hebei Fengjia New Material Co., Ltd
2025-04-23	Alpha-D-Lactose monohydrate 5989-81-1	US $10.00 / KG	1KG	99%	10 mt	Hebei Chuanghai Biotechnology Co., Ltd
2025-04-04	Alpha-D-Lactose monohydrate 5989-81-1	US $0.00-0.00 / KG	1KG	98%	1tone	Henan Aochuang Chemical Co.,Ltd.

Alpha-D-Lactose monohydrate
5989-81-1
US $3.00 / kg
0.99
Hebei Fengjia New Material Co., Ltd

Alpha-D-Lactose monohydrate
5989-81-1
US $10.00 / KG
99%
Hebei Chuanghai Biotechnology Co., Ltd

Alpha-D-Lactose monohydrate
5989-81-1
US $0.00-0.00 / KG
98%
Henan Aochuang Chemical Co.,Ltd.

Alpha-D-Lactose monohydrate Spectrum

Alpha-D-Lactose monohydrate(5989-81-1)¹HNMR Alpha-D-Lactose monohydrate(5989-81-1)IR Alpha-D-Lactose monohydrate(5989-81-1)Raman Alpha-D-Lactose monohydrate(5989-81-1)FT-IR

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alpha-D-Lactose Monohydrate, 99.5+%, 2-4% beta-isoMer alpha-D-Lactose Monohydrate, USP/NF, Ph.Eur., JP 250GR 4-O-beta-D-Galactopyranosyl-alpha-D-glucopyranose monohydrate LACTOSE MONOHYDRATE, a-(RG) Pharmatose 325 Pharmatose 50M Pharmatose 90M Pharmatose DCL 11 Zeparox ^a-D-Lactose Monohydrate, 97%, 97% alpha-D(+)-La BETA-D-GAL-(1->4)-ALPHA-D-GLC BETA-D-GAL-(1->4)-ALPHA-D-GLC, MONOHYDRATE LACTOSE MONOHYDRATE (ALPHA-FORM) LACTOSE, A- D(+)-LACTOSE HYDRATE D-(+)-LACTOSE HYDRATE,ALPHA-FORM ALPHA-D(+)-LACTOBIOSE MONOHYDRATE ALPHA-D-(+)-LACTOSE, HYDRATE ALPHA-D(+)-LACTOSE MONOHYDRATE ALPHA-D-LACTOSE MONOHYDRATE A-LACTOBIOSE ALPHA-LACTOSE MONOHYDRATE, BIOXTRA ALPHA-LACTOSE MONOHYDRATE,>=99% (GC) β-D-Gal-(1→4)-α-D-Glc 4-O-β-D-Galactopyranosyl-α-D-glucose 4-O-BETA-D-GALACTOPYRANOSYL-ALPHA-D-GLUCOSE 4-O-BETA-D-GALACTOPYRANOSYL-ALPHA-D-GLUCOSE MONOHYDRATE D-LACTOSE MONOHYDRATE A.C.S. REAGENT A-LACTOSE MONOHYDRATE CELL CULTURE*TESTE D LACTOSE MONOHYDRATE 500MG NEAT A-LACTOSE MONOHYDRATE SIGMAULTRA Α-D-LACTOSE MONOHYDRATE GR ACS Α-D-LACTOSE MONOHYDRATE 99.5+% Α-D-LACTOSE MONOHYDRATE USP NF PH.EUR.,JP beta-D-Gal-[1.4]-alpha-D-Glc.H2O alpha-D-Lactose monohydrate, 99.5+% 4-O-beta-d-Galactopyranosyl 4-O-beta-d-Galactopyranosyl-d-glucose alpha-D-Glucopyranose, 4-O-beta-D-galactopyranosyl-, monohydrate Saccharum lactis alpha-D-Lactose monohydrate, USP/NF, Ph.Eur., JP alpha-D-Lactose, monohydrate, reagent ACS à-d-lactose monohydrate LACTOSE USP a-D-Lactose monohydrate β-D-Gal-(1-4)-α-D-Glc, Milk sugar, 4-O-β-D-Galactopyranosyl-α-D-glucose α-Lactose monohydrate, β-D-Gal-(1-4)-α-D-Glc, Milk sugar, 4-O-β-D-Galactopyranosyl-α-D-glucose α-Lactose monohydrate ,98% Lactose Monohydrate (500 mg) D -LACTOSE, ACS 4-O-β-D-Galactopyranosyl-α-D-glucose α-Lactose monohydrate, AR，≥98.0% (HPLC) 4-O-β-D-Galactopyranosyl-α-D-glucopyranose monohydrate (2S,3R,4R,5S,6R)-6-(hydroxymethyl)-5-(((2S,3R,4S,5R,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)tetrahydro-2H-pyran-2-yl)oxy)tetrahydro-2H-pyran-2,3,4-triol (2S,3R,4R,5S,6R)-6-(hydroxymethyl)-5-(((2S,3R,4S,5R,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)tetrahydro-2H-pyran-2-yl)oxy)tetrahydro-2H-pyran-2,3,4-triol hydrate Alpha-D-Lactose monohydrate USP/EP/BP Lactose / anhydrous lactose Inhalac 120 (contains β anomer)