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ChemicalBook >> CAS DataBase List >>(5-Methyl-2-oxo-1,3-dioxol-4-yl)methyl 4-nitrophenyl carbonate

(5-Methyl-2-oxo-1,3-dioxol-4-yl)methyl 4-nitrophenyl carbonate

(5-Methyl-2-oxo-1,3-dioxol-4-yl)methyl 4-nitrophenyl carbonate Structure
(5-Methyl-2-oxo-1,3-dioxol-4-yl)methyl 4-nitrophenyl carbonate structure
CAS No.
173604-87-0
Chemical Name:
(5-Methyl-2-oxo-1,3-dioxol-4-yl)methyl 4-nitrophenyl carbonate
Synonyms
(5-Methyl-2-oxo-1,3-dioxol-4-yl)methylp-nitrophenyl carbonate;(5-Methyl-2-oxo-1,3-dioxol-4-yl)methyl 4-nitrophenyl carbonate;(5-methyl-2-oxo-1,3-dioxopentene-4-yl) methyl 4-nitrophenyl carbonate;Carbonic acid, (5-methyl-2-oxo-1,3-dioxol-4-yl)methyl 4-nitrophenyl -ester;carbonic acid 5-methyl-2-oxo-[1,3]dioxol-4-ylmethyl ester 4-nitro-phenyl ester
CBNumber:
CB01876499
Molecular Formula:
C12H9NO8
Molecular Weight:
295.2
MDL Number:
MFCD04035556
MOL File:
173604-87-0.mol
Last updated:2025-03-20 19:16:41
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(5-Methyl-2-oxo-1,3-dioxol-4-yl)methyl 4-nitrophenyl carbonate Properties

Boiling point 434.8±55.0 °C(Predicted)
Density 1.491

SAFETY

Risk and Safety Statements

Symbol(GHS)  GHS hazard pictogramsGHS hazard pictograms
GHS03,GHS09
Signal word  Warning
Hazard statements  H272-H411
Precautionary statements  P210-P220-P221P280-P370+P378-P501

(5-Methyl-2-oxo-1,3-dioxol-4-yl)methyl 4-nitrophenyl carbonate Chemical Properties,Uses,Production

Uses

(5-Methyl-2-oxo-1,3-dioxol-4-YL)methyl 4-nitrophenyl carbonate is a pharmaceutical intermediate compound for the preparation of Ceftobiprole medocaril, a broad-spectrum, 5th generation cephalosporin with activity against gram-positive bacteria (e.g. methicillin-resistant).

Synthesis

(5-Methyl-2-oxo-1,3-dioxol-4-yl)methyl 4-nitrophenyl carbonate is prepared by the reaction of 4-Nitrophenyl chloroformate and Bis(4-nitrophenyl) carbonate. The specific synthesis steps are as follows:
4-Hydroxymethyl-5-methyl-1,3-doxolene-2-one (5.59 g) and pyridine (3.74 g) were dissolved in 50 mL of chloroform and cooled in an ice bath. 4-Nitrophenylchloroformate (9.46 g) dissolvedin chloroform (50 mL) was added dropwise to the above solution. The mixture was stirred for 16 hours at room temperature. The reaction mixture was cooled in ice and washed with ice cold 1percent sodium hydroxide, 1N hydrochloric acid, water and brine and dried over sodium sulfate. Evaporation of the organic layer resulted in 11.2 g of crude product, which was crystallized from chloroform/hexane. The crystals formed were filtered and washed with ice cold hexane/chloroform (1:1), to obtain the pure 4-nitrophenyl carbonate (9.11 g, 81percent); mp 116°-117°; 1 H NMR (CDCl3) δ2.23 (s, 3H), 5.05 (s,2H), 7.41 (d, 2H), 8.3 (s, 2H); 13 C NMR (CDCl3), δ9.43, 58.07, 121.69, 121.35, 132.15, 141.42, 145.57, 151.66, 152.19, 155.05; IR (KBr) 1779, 1811, 1525, 1247, 1221, 1207 cm-1.
(5-Methyl-2-oxo-1,3-dioxol-4-yl)methyl 4-nitrophenyl carbonate synthesis

(5-Methyl-2-oxo-1,3-dioxol-4-yl)methyl 4-nitrophenyl carbonate Preparation Products And Raw materials

Raw materials

Preparation Products

(5-Methyl-2-oxo-1,3-dioxol-4-yl)methyl 4-nitrophenyl carbonate Suppliers

Global( 71)Suppliers
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BOC Sciences 		+1-631-485-4226 inquiry@bocsci.com United States 19552 58
CONIER CHEM AND PHARMA LIMITED 		+8618523575427 sales@conier.com China 49732 58
Neostar United (Changzhou) Industrial Co., Ltd. 		+86-0519-85551759 +8613506123987 marketing1@neostarunited.com China 8831 58
Kindchem(Nanjing)Co.,Ltd 		+86-025-025-85281586 +8618651653755 sales@kindchem.cn China 1226 58
Career Henan Chemica Co 		+86-0371-86658258 +8613203830695 laboratory@coreychem.com China 30231 58
Dayang Chem (Hangzhou) Co.,Ltd. 		+86-0571-88938639 +8617705817739 info@dycnchem.com China 52849 58
CD Chemical Group Limited 		+8615986615575 info@codchem.com China 20342 58
Labnetwork lnc. 		+86-27-50766799 +8618062016861 contact@labnetwork.com China 19987 58
Hangzhou MolCore BioPharmatech Co.,Ltd. 		+86-057181025280; +8617767106207 sales@molcore.com China 49734 58
Chemtour Biotech Co., Ltd 		+8617327281506 market@chemtour.com China 1521 58
Supplier Advantage
BOC Sciences 		58
CONIER CHEM AND PHARMA LIMITED 		58
Neostar United (Changzhou) Industrial Co., Ltd. 		58
Kindchem(Nanjing)Co.,Ltd 		58
Career Henan Chemica Co 		58
Dayang Chem (Hangzhou) Co.,Ltd. 		58
CD Chemical Group Limited 		58
Labnetwork lnc. 		58
Hangzhou MolCore BioPharmatech Co.,Ltd. 		58
Chemtour Biotech Co., Ltd 		58

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(5-Methyl-2-oxo-1,3-dioxol-4-yl)methyl 4-nitrophenyl carbonate pictures 2025-03-21 (5-Methyl-2-oxo-1,3-dioxol-4-yl)methyl 4-nitrophenyl carbonate
173604-87-0
 US $0.00-0.00 / KG 1KG 98.0% 10000KGS Shaanxi Dideu New Materials Co. Ltd

173604-87-0((5-Methyl-2-oxo-1,3-dioxol-4-yl)methyl 4-nitrophenyl carbonate)Related Search:

1,4-Dioxane Barium carbonate DIOXOPROMETHAZINE HCL Ammonium carbonate Selenium dioxide
TRIS(4-NITROPHENYL) PHOSPHATE Calcium carbonate Sodium carbonate Dimethyl carbonate dimethylsilanediol
Methyl cyclopentenolone Methyl Cyclopentene Methyl bromide Carbonate
POLY(BISPHENOL A CARBONATE) (5-Methyl-2-oxo-1,3-dioxol-4-yl)methyl 4-nitrophenyl carbonate

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(5-Methyl-2-oxo-1,3-dioxol-4-yl)methylp-nitrophenyl carbonate (5-Methyl-2-oxo-1,3-dioxol-4-yl)methyl 4-nitrophenyl carbonate Carbonic acid, (5-methyl-2-oxo-1,3-dioxol-4-yl)methyl 4-nitrophenyl -ester carbonic acid 5-methyl-2-oxo-[1,3]dioxol-4-ylmethyl ester 4-nitro-phenyl ester (5-methyl-2-oxo-1,3-dioxopentene-4-yl) methyl 4-nitrophenyl carbonate 173604-87-0 C12H9NO8