BIX 02188
- CAS No.
- 1094614-84-2
- Chemical Name:
- BIX 02188
- Synonyms
- CS-38;BIX 02188;(E/Z)-BIX02188;BIX 02188, >=98%;BIX 02188 USP/EP/BP;BIX 02188(BIX-02188;BIX 02188(BIX-02188;BIX02188);BIX-02188(Random Configuration);BIX-02188 BIX02188MEK5 inhibitor potent and selective;3-(((3-((Dimethylamino)methyl)phenyl)amino)(phenyl)methylene)-2-oxoindoline-6-carboxamide
- CBNumber:
- CB02489917
- Molecular Formula:
- C25H24N4O2
- Molecular Weight:
- 412.48366
- MDL Number:
- MFCD18157583
- MOL File:
- 1094614-84-2.mol
Melting point | >268oC (dec.) |
---|---|
Boiling point | 615.8±55.0 °C(Predicted) |
Density | 1.283 |
storage temp. | Keep in dark place,Sealed in dry,Store in freezer, under -20°C |
solubility | DMSO (Slightly), Methanol (Slightly) |
form | Solid |
pka | 11.19±0.20(Predicted) |
color | Yellow |
FDA UNII | 4Y3VYY2X83 |
SAFETY
Risk and Safety Statements
Symbol(GHS) | GHS07 |
---|---|
Signal word | Warning |
Hazard statements | H302-H315-H319-H335 |
Precautionary statements | P261-P305+P351+P338 |
HS Code | 2933998090 |
BIX 02188 price More Price(32)
Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
---|---|---|---|---|---|---|---|
TRC | B591685 | BIX02188 | 1094614-84-2 | 10mg | $150 | 2021-12-16 | Buy |
Usbiological | 162918 | BIX02188 | 1094614-84-2 | 10mg | $460 | 2021-12-16 | Buy |
American Custom Chemicals Corporation | KIN0000917 | 3-[[[3-[(DIMETHYLAMINO)METHYL]PHENYL]AMINO]PHENYLMETHYLENE]-2,3-DIHYDRO-2-OXO-1H-INDOLE-6-CARBOXAMIDE 95.00% | 1094614-84-2 | 5MG | $496.31 | 2021-12-16 | Buy |
Biorbyt Ltd | orb154720 | BIX02188 (BIX 02188) >98% | 1094614-84-2 | 100mg | $765 | 2021-12-16 | Buy |
AK Scientific | X7394 | (Z)-3-((3-((dimethylamino)methyl)phenylamino)(phenyl)methylene)-2-oxoindoline-6-carboxamide | 1094614-84-2 | 50mg | $876 | 2021-12-16 | Buy |
BIX 02188 Chemical Properties,Uses,Production
Uses
BIX02188 MEK inhibitor, prevents cell proliferation and induces apoptosis. Can be applied towards treatments of cancers and proliferative cell diseases.
Biological Activity
bix 02188 is a selective inhibitor of mek5 with ic50 value of 4.3 nm 1.bix 02188 belongs to the indolinone kinase inhibitor series. it selectively inhibited the catalytic activity of mek5 but not other closely related kinases such as mek1, mek2, erk2 and jnk2. bix 02188 also inhibited erk5 with ic50 value of 810 nm. in hela cells, treatment of bix 02188 inhibited the phosphorylation of erk5 but not erk1/2. besides that, bix 02188 prevented the transcription of the downstream substrate mef2c in hela and hek293 cells. when tested with a panel of 79 kinases, bix 02188 showed some degree of inhibition of the kinases csf1r, kit and lck with ic50 values of 280 nm, 550 nm and 390 nm, respectively 1.
target
MEK5
References
1. tatake r j, o’neill m m, kennedy c a, et al. identification of pharmacological inhibitors of the mek5/erk5 pathway. biochemical and biophysical research communications, 2008, 377(1): 120-125.
BIX 02188 Preparation Products And Raw materials
Raw materials
Preparation Products
Supplier | Tel | Country | ProdList | Advantage | |
---|---|---|---|---|---|
Capot Chemical Co.,Ltd. | 571-85586718 +8613336195806 | sales@capotchem.com | China | 29798 | 60 |
ATK CHEMICAL COMPANY LIMITED | +undefined-21-51877795 | ivan@atkchemical.com | China | 32760 | 60 |
Biochempartner | 0086-13720134139 | candy@biochempartner.com | CHINA | 967 | 58 |
Hubei Jusheng Technology Co.,Ltd. | 18871490254 | linda@hubeijusheng.com | CHINA | 28180 | 58 |
CONIER CHEM AND PHARMA LIMITED | +8618523575427 | sales@conier.com | China | 49391 | 58 |
Career Henan Chemica Co | +86-0371-86658258 +8613203830695 | laboratory@coreychem.com | China | 30253 | 58 |
HANGZHOU CLAP TECHNOLOGY CO.,LTD | 86-571-88216897,88216896 13588875226 | sales@hzclap.com | CHINA | 6313 | 58 |
Dideu Industries Group Limited | +86-29-89586680 +86-15129568250 | 1026@dideu.com | China | 24722 | 58 |
Zhejiang J&C Biological Technology Co.,Limited | +1-2135480471 +1-2135480471 | sales@sarms4muscle.com | China | 10522 | 58 |
TargetMol Chemicals Inc. | +1-781-999-5354 | support@targetmol.com | United States | 19973 | 58 |