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ChemicalBook >> CAS DataBase List >>1-(4-Amino-2-methylbenzoyl)-7-chloro-1,2,3,4-tetrahydro-5H-1-benzazepin-5-one

1-(4-Amino-2-methylbenzoyl)-7-chloro-1,2,3,4-tetrahydro-5H-1-benzazepin-5-one

1-(4-Amino-2-methylbenzoyl)-7-chloro-1,2,3,4-tetrahydro-5H-1-benzazepin-5-one Structure
1-(4-Amino-2-methylbenzoyl)-7-chloro-1,2,3,4-tetrahydro-5H-1-benzazepin-5-one structure
CAS No.
137977-97-0
Chemical Name:
1-(4-Amino-2-methylbenzoyl)-7-chloro-1,2,3,4-tetrahydro-5H-1-benzazepin-5-one
Synonyms
1-(4-amino-2-methylbenzoyl)-7-chloro-1,2,3,4-tetrahydro-5H-benzo[b]azepin-5-one;Tovaptan impurity 39;Tolvaptan Impurity 10;Histaprodifen Impurity 1;Tolvaptan Intermediate 3;1-(4-Amino-2-methylbenzoyl)-7-chloro-1,2,3,4-tetrahydro-5H-1...;1-(4-amino-2-methylbenzoyl)-7-chloro-3,4-dihydro-2H-1-benzazepin-5-one;1-(4-Amino-2-methylbenzoyl)-7-chloro-1,2,3,4-tetrahydrobenzo[b]azepin-5-one;1-(4-aMino-2-Methylbenzoyl)-7-chloro-3,4-dihydro-1H-benzo[b]azepin-5(2H)-one;7-Chloro-5-oxo-1-(2-methyl-4-aminobenzoyl)-2,3,4,5-tetrahydro-1H-benzazepine
CBNumber:
CB02500621
Molecular Formula:
C18H17ClN2O2
Molecular Weight:
328.79
MDL Number:
MFCD19440799
MOL File:
137977-97-0.mol
Last updated:2024-08-12 17:17:06
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1-(4-Amino-2-methylbenzoyl)-7-chloro-1,2,3,4-tetrahydro-5H-1-benzazepin-5-one Properties

Melting point 186-189°C
Boiling point 565.4±50.0 °C(Predicted)
Density 1.320
storage temp. -20°C Freezer
solubility DMSO (Slightly), Methanol (Slightly)
pka 2.28±0.10(Predicted)
form Solid
color Off-White to Pale Yellow
InChI InChI=1S/C18H17ClN2O2/c1-11-9-13(20)5-6-14(11)18(23)21-8-2-3-17(22)15-10-12(19)4-7-16(15)21/h4-7,9-10H,2-3,8,20H2,1H3
InChIKey FLJCJPKXJWRZJB-UHFFFAOYSA-N
SMILES N1(C(=O)C2=CC=C(N)C=C2C)C2=CC=C(Cl)C=C2C(=O)CCC1
FDA UNII ZQM32LG67U

SAFETY

Risk and Safety Statements

Symbol(GHS)  GHS hazard pictograms
GHS07
Signal word  Warning
Hazard statements  H302-H312-H332
Precautionary statements  P280

1-(4-Amino-2-methylbenzoyl)-7-chloro-1,2,3,4-tetrahydro-5H-1-benzazepin-5-one price More Price(14)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Biosynth Carbosynth FA151721 1-(4-Amino-2-methylbenzoyl)-7-chloro-1,2,3,4-tetrahydro-5H-1-benzazepin-5-one 137977-97-0 500mg $100 2021-12-16 Buy
AK Scientific Z3611 7-Chloro-1-(4-amino-2-methylbenzoyl)-1,2,3,4-tetrahydrobenzo[b]azepin-5-one 137977-97-0 250mg $131 2021-12-16 Buy
Biosynth Carbosynth FA151721 1-(4-Amino-2-methylbenzoyl)-7-chloro-1,2,3,4-tetrahydro-5H-1-benzazepin-5-one 137977-97-0 1g $150 2021-12-16 Buy
Biosynth Carbosynth FA151721 1-(4-Amino-2-methylbenzoyl)-7-chloro-1,2,3,4-tetrahydro-5H-1-benzazepin-5-one 137977-97-0 2g $250 2021-12-16 Buy
Biosynth Carbosynth FA151721 1-(4-Amino-2-methylbenzoyl)-7-chloro-1,2,3,4-tetrahydro-5H-1-benzazepin-5-one 137977-97-0 5G $400 2021-12-16 Buy
Product number Packaging Price Buy
FA151721 500mg $100 Buy
Z3611 250mg $131 Buy
FA151721 1g $150 Buy
FA151721 2g $250 Buy
FA151721 5G $400 Buy

1-(4-Amino-2-methylbenzoyl)-7-chloro-1,2,3,4-tetrahydro-5H-1-benzazepin-5-one Chemical Properties,Uses,Production

Uses

1,2,3,4-Tetrahydro-1-(4-amino-2-methylbenzoyl)-7-chloro-5H-1-benzazepin-5-one is an intermediate used in the synthetic preparation of Tolvaptan (T536650), a selective nonpeptide arginine vasopressin V2 receptor antagonist.

Uses

1-(4-Amino-2-methylbenzoyl)-7-chloro-1,2,3,4-tetrahydro-5H-1-benzazepin-5-one is an intermediate used in the synthetic preparation of Tolvaptan (T536650), a selective nonpeptide arginine vasopressin V 2 receptor antagonist.

1-(4-Amino-2-methylbenzoyl)-7-chloro-1,2,3,4-tetrahydro-5H-1-benzazepin-5-one Preparation Products And Raw materials

Raw materials

Preparation Products

1-(4-Amino-2-methylbenzoyl)-7-chloro-1,2,3,4-tetrahydro-5H-1-benzazepin-5-one Suppliers

Global( 147)Suppliers
Supplier Tel Email Country ProdList Advantage
Enki Biopharmaceuticals (Shanghai) Limited
+86-0086-2157680326 +8613916707528 yusu@enkibiopharma.com China 46 58
Changzhou Rokechem Technology Co., Ltd. 		18758118018 sales001@rokechem.com China 255 58
Shanghai Daken Advanced Materials Co.,Ltd 		+86-371-66670886 info@dakenam.com China 18648 58
Henan Tianfu Chemical Co.,Ltd. 		+86-0371-55170693 +86-19937530512 info@tianfuchem.com China 21639 55
Shanghai Time Chemicals CO., Ltd. 		+86-021-57951555 +8617317452075 jack.li@time-chemicals.com China 1803 55
career henan chemical co 		+86-0371-86658258 +8613203830695 sales@coreychem.com China 29886 58
Nanjing Dolon Biotechnology Co.,Ltd. 		18905173768 sales@dolonchem.com CHINA 2972 58
Cangzhou Wanyou New Material Technology Co.,Ltd 		18631714998 sales@czwytech.com CHINA 904 58
Chongqing Chemdad Co., Ltd 		+86-023-6139-8061 +86-86-13650506873 sales@chemdad.com China 39894 58
Shanghai Jinghao Pharmaceutical Co.,Ltd 		+86-21-68900963 sales@jinghaopharma.com CHINA 153 58
Supplier Advantage
Enki Biopharmaceuticals (Shanghai) Limited
58
Changzhou Rokechem Technology Co., Ltd. 		58
Shanghai Daken Advanced Materials Co.,Ltd 		58
Henan Tianfu Chemical Co.,Ltd. 		55
Shanghai Time Chemicals CO., Ltd. 		55
career henan chemical co 		58
Nanjing Dolon Biotechnology Co.,Ltd. 		58
Cangzhou Wanyou New Material Technology Co.,Ltd 		58
Chongqing Chemdad Co., Ltd 		58
Shanghai Jinghao Pharmaceutical Co.,Ltd 		58

View Lastest Price from 1-(4-Amino-2-methylbenzoyl)-7-chloro-1,2,3,4-tetrahydro-5H-1-benzazepin-5-one manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
1-(4-Amino-2-methylbenzoyl)-7-chloro-1,2,3,4-tetrahydro-5H-1-benzazepin-5-one pictures 2024-11-02 1-(4-Amino-2-methylbenzoyl)-7-chloro-1,2,3,4-tetrahydro-5H-1-benzazepin-5-one
137977-97-0
 US $0.00-0.00 / Kg/Drum 1KG 99%min 1000KGS WUHAN FORTUNA CHEMICAL CO., LTD
1-(4-Amino-2-methylbenzoyl)-7-chloro-1,2,3,4-tetrahydro-5H-1-benzazepin-5-one pictures 2024-10-29 1-(4-Amino-2-methylbenzoyl)-7-chloro-1,2,3,4-tetrahydro-5H-1-benzazepin-5-one
137977-97-0
 US $0.00-0.00 / kg 1kg 99.0% 5000 Enki Biopharmaceuticals (Shanghai) Limited
Tolvaptan Impurity 16 pictures 2024-09-20 Tolvaptan Impurity 16
137977-97-0
 US $0.00-0.00 / mg 10mg 98% 500mg ShenZhen H&D Pharmaceutical Technology Co., LTD

137977-97-0(1-(4-Amino-2-methylbenzoyl)-7-chloro-1,2,3,4-tetrahydro-5H-1-benzazepin-5-one)Related Search:

Tolvaptan Impurity 11 Tolvaptan Impurity 26 7-Chloro-1,2,3,4-tetrahydrobenzo(b)azepin-5-one 5-Dehydro Tolvaptan 7-Chloro-1,2,3,4-tetrahydro-1-(2-methyl-4-nitrobenzoyl)-5H-1-benzazepin-5-one
Tolvaptan Impurity 3 (DM-4104) Tolvaptan Impurity 30 7-Chloro-1,2,3,4-tetrahydro-1-[(4-methylphenyl)sulfonyl]-5H-1-benzazepin-5-one 2-Methyl-4-nitrobenzoic acid Tolvaptan Impurity 4 (DM-4105)
Ethyl 7-Chloro-5-oxo-1-toxyl-2,3,4,5,-tetrahydro-1H-benzo[b]azepine-4-carboxylate 5-Chloro-2-[(4-ethoxy-4-oxobutyl)[(4-methylphenyl)sulfonyl]amino]benzoic acid methyl ester Tolvaptan Impurity 21 Tolvaptan Impurity 18 Tolvaptan Impurity 13
Tolvaptan Impurity 17 Tolvaptan impurity 2 Tolvaptan Impurity 20

1of4

1-(4-Amino-2-methylbenzoyl)-7-chloro-1,2,3,4-tetrahydro-5H-1-benzazepin-5-one 5H-1-Benzazepin-5-one, 1-(4-aMino-2-Methylbenzoyl)-7-chloro-1,2,3,4-tetrahydro- 1,2,3,4-Tetrahydro-1-(4-amino-2-methylbenzoyl)-7-chloro-5H-1-benzazepin-5-one 1-(4-aMino-2-Methylbenzoyl)-7-chloro-3,4-dihydro-1H-benzo[b]azepin-5(2H)-one 1-(4-Amino-2-Methylbenzoyl)-7-Chloro-1,2,3,4-Tetrahydro-5H-1-benzazepine-5-One 1-(4-amino-2-methylbenzoyl)-7-chloro-3,4-dihydro-2H-1-benzazepin-5-one Tolvaptan Intermediate 3 1-(4-Amino-2-methylbenzoyl)-7-chloro-1,2,3,4-tetrahydro-5H-1... 1-(4-Amino-2-methylbenzoyl)-7-chloro-1,2,3,4-tetrahydrobenzo[b]azepin-5-one Tolvaptan Impurity 10 1-(4-amino-2-methylbenzoyl)-7-chloro-1,2,3,4-tetrahydro-5H-benzo[b]azepin-5-one 1-(4- amino -2- methylbenzoyl) -7- chloro -1,2,3,4- tetrahydro -5H-1- benzoazepine -5- one * Tovaptan impurity 39 7-Chloro-5-oxo-1-(2-methyl-4-aminobenzoyl)-2,3,4,5-tetrahydro-1H-benzazepine Histaprodifen Impurity 1 137977-97-0 Pharmaceutical Intermediates 137977-97-0