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1-[5-[(3,4-dihydro-4-oxo-1-phthalazinyl)Methyl]-2-fluorobenzoyl]hexahydro-1H-1,4-diazepine

1-[5-[(3,4-dihydro-4-oxo-1-phthalazinyl)Methyl]-2-fluorobenzoyl]hexahydro-1H-1,4-diazepine Structure
1-[5-[(3,4-dihydro-4-oxo-1-phthalazinyl)Methyl]-2-fluorobenzoyl]hexahydro-1H-1,4-diazepine structure
CAS No.
763111-49-5
Chemical Name:
1-[5-[(3,4-dihydro-4-oxo-1-phthalazinyl)Methyl]-2-fluorobenzoyl]hexahydro-1H-1,4-diazepine
Synonyms
KU0058948;KU 0058948;KU-0058948;Venadaparib Impurity 1;1-[5-[(3,4-dihydro-4-oxo-1-phthalazinyl)Methyl]-2-fluorobenzoyl]hexahydro-1H-1,4-diazepine;4-[[4-fluoro-3-[(hexahydro-1H-1,4-diazepin-1-yl)carbonyl]phenyl]Methyl]-1(2H)-phthalazinone;1(2H)-Phthalazinone, 4-[[4-fluoro-3-[(hexahydro-1H-1,4-diazepin-1-yl)carbonyl]phenyl]methyl]-
CBNumber:
CB02622756
Molecular Formula:
C21H21FN4O2
Molecular Weight:
380.42
MDL Number:
MOL File:
763111-49-5.mol
Last updated:2024-10-28 16:48:35
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1-[5-[(3,4-dihydro-4-oxo-1-phthalazinyl)Methyl]-2-fluorobenzoyl]hexahydro-1H-1,4-diazepine Properties

Melting point >150°C (dec.)
storage temp. Refrigerator
solubility DMSO (Slightly), Methanol (Slightly)
form Solid
color Pale Yellow to Yellowish Beige

1-[5-[(3,4-dihydro-4-oxo-1-phthalazinyl)Methyl]-2-fluorobenzoyl]hexahydro-1H-1,4-diazepine price

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Usbiological 015404 KU-0058948 763111-49-5 10mg $566 2021-12-16 Buy
Medical Isotopes, Inc. 51954 KU-0058948 763111-49-5 10mg $725 2021-12-16 Buy
Product number Packaging Price Buy
015404 10mg $566 Buy
51954 10mg $725 Buy

1-[5-[(3,4-dihydro-4-oxo-1-phthalazinyl)Methyl]-2-fluorobenzoyl]hexahydro-1H-1,4-diazepine Chemical Properties,Uses,Production

Uses

KU-0058948 is a poly (ADP-ribose) polymerase (PARP) inhibitor. Studies show that KU-0058948 is a potent agonist that activates transfected extracellular signal-regulated kinase 8 (ERK8) in cells. KU-0058948 induces cell cycle arrest and apoptosis of primary myeloid leukemic cells and myeloid leukemic cell lines in vitro

Uses

KU-0058948 is a poly (ADP-ribose) polymerase (PARP) inhibitor. Studies show that KU-0058948 a potent agonist that activates transfected extracellular signal-regulated kinase 8 (ERK8) in cells. KU-0058948 induces cell cycle arrest and apoptosis of primary myeloid leukemic cells and myeloid leukemic cell lines in vitro

1-[5-[(3,4-dihydro-4-oxo-1-phthalazinyl)Methyl]-2-fluorobenzoyl]hexahydro-1H-1,4-diazepine synthesis

763114-26-7
763111-49-5
Synthesis of 1-[5-[(3,4-dihydro-4-oxo-1-phthalazinyl)Methyl]-2-fluorobenzoyl]hexahydro-1H-1,4-diazepine from 2-fluoro-5-((4-oxo-3,4-dihydrophthalazin-1-yl)Methyl)benzoic acid

1-[5-[(3,4-dihydro-4-oxo-1-phthalazinyl)Methyl]-2-fluorobenzoyl]hexahydro-1H-1,4-diazepine Preparation Products And Raw materials

Raw materials

Preparation Products

1-[5-[(3,4-dihydro-4-oxo-1-phthalazinyl)Methyl]-2-fluorobenzoyl]hexahydro-1H-1,4-diazepine Suppliers

Global( 16)Suppliers
Supplier Tel Email Country ProdList Advantage
TargetMol Chemicals Inc. 		+8613564774135 zijue.cai@tsbiochem.com United States 19881 58
J & K SCIENTIFIC LTD. 010-82848833 400-666-7788 jkinfo@jkchemical.com China 94657 76
Chemsky（shanghai）International Co.,Ltd. 021-50135380 shchemsky@sina.com China 32321 50
Tcichem, Inc. 13918644899 tianchong009@hotmail.com China 1784 55
Shanghai Benso Pharmaceutical Technology Co., Ltd. 15088289376 248775804@qq.com China 4987 58
Shenzhen Polymeri Biochemical Technology Co., Ltd. +86-400-002-6226 +86-13028896684; sales@rrkchem.com China 57423 58
Wuxi Donghe Pharmaceutical Technology Co., Ltd. 63313187 15358055255 63313187@qq.com China 1987 58
Energy Chemical 021-58432009 400-005-6266 marketing@energy-chemical.com China 44918 58
TargetMol Chemicals Inc. 4008200310 marketing@tsbiochem.com China 24644 58
Shanghai Yifei Biotechnology Co. , Ltd. 021-65675885 18964387627 customer_service@efebio.com China 11974 58
Supplier Advantage
TargetMol Chemicals Inc. 		58
J & K SCIENTIFIC LTD. 76
Chemsky（shanghai）International Co.,Ltd. 50
Tcichem, Inc. 55
Shanghai Benso Pharmaceutical Technology Co., Ltd. 58
Shenzhen Polymeri Biochemical Technology Co., Ltd. 58
Wuxi Donghe Pharmaceutical Technology Co., Ltd. 58
Energy Chemical 58
TargetMol Chemicals Inc. 58
Shanghai Yifei Biotechnology Co. , Ltd. 58

View Lastest Price from 1-[5-[(3,4-dihydro-4-oxo-1-phthalazinyl)Methyl]-2-fluorobenzoyl]hexahydro-1H-1,4-diazepine manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
KU-0058948 pictures 2024-10-28 KU-0058948
763111-49-5
 US $1520.00-1980.00 / mg 10g TargetMol Chemicals Inc.
  • KU-0058948 pictures
  • KU-0058948
    763111-49-5
  • US $1520.00-1980.00 / mg
  • TargetMol Chemicals Inc.
1-[5-[(3,4-dihydro-4-oxo-1-phthalazinyl)Methyl]-2-fluorobenzoyl]hexahydro-1H-1,4-diazepine 4-[[4-fluoro-3-[(hexahydro-1H-1,4-diazepin-1-yl)carbonyl]phenyl]Methyl]-1(2H)-phthalazinone KU 0058948 KU0058948 KU-0058948 1(2H)-Phthalazinone, 4-[[4-fluoro-3-[(hexahydro-1H-1,4-diazepin-1-yl)carbonyl]phenyl]methyl]- Venadaparib Impurity 1 763111-49-5 Apoptosis Aromatics Heterocycles Inhibitors Intermediates & Fine Chemicals Pharmaceuticals