5-R-Rivaroxaban
- CAS No.
- 865479-71-6
- Chemical Name:
- 5-R-Rivaroxaban
- Synonyms
- R-Rivaroxaban;Rivaroxaban A;Rivaroxaban-6;5-R-Rivaroxaban;ent-Rivaroxaban;Rivaroxyban R-isomer;Rivaroxaban R-Isomer;XARELTO; BAY 59-7939;R-Rivaroxaban Impurity;R-Isomer of Rivaroxaban
- CBNumber:
- CB02624033
- Molecular Formula:
- C19H18ClN3O5S
- Molecular Weight:
- 435.88
- MDL Number:
- MFCD17171369
- MOL File:
- 865479-71-6.mol
- MSDS File:
- SDS
Melting point | >227°C (dec.) |
---|---|
Boiling point | 732.6±60.0 °C(Predicted) |
Density | 1.460 |
storage temp. | Refrigerator |
solubility | Acetonitrile (Slightly, Heated, Sonicated), DMSO (Slightly, Sonicated), Methanol |
form | Solid |
pka | 13.36±0.46(Predicted) |
color | White to Off-White |
FDA UNII | RJP4GEG36M |
5-R-Rivaroxaban price More Price(21)
Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
---|---|---|---|---|---|---|---|
TRC | R538005 | ent-Rivaroxaban | 865479-71-6 | 25mg | $180 | 2021-12-16 | Buy |
Usbiological | 448268 | ent-Rivaroxaban | 865479-71-6 | 10mg | $368 | 2021-12-16 | Buy |
ChemScene | CS-0730 | 5-R-Rivaroxaban 99.72% | 865479-71-6 | 50mg | $370 | 2021-12-16 | Buy |
ApexBio Technology | A3126 | 5-R-Rivaroxaban | 865479-71-6 | 50mg | $370 | 2021-12-16 | Buy |
Medical Isotopes, Inc. | 98910 | ent-Rivaroxaban | 865479-71-6 | 1mg | $385 | 2021-12-16 | Buy |
5-R-Rivaroxaban Chemical Properties,Uses,Production
Uses
ent-Rivaroxaban is the R-isomer of Rivaroxaban (R538000), which is a novel antithrombotic agent. A highly potent and selective, direct FXa inhibitor.
Biological Activity
5-r-rivaroxaban is a selective inhibitor of human factor xa with ic50 value of 0.7 nmol/l [1].factor xa is a serine endopeptidase enzyme and plays an important role in the convergence point of the intrinsic and extrinsic pathways in blood coagulation system [2].5-r-rivaroxaban is an oral, direct factor xa inhibitor and the inhibition is species-dependent. when tested with purified factoe xa from human or rabbit, 5-r-rivaroxaban showed similar affinity with ic50 value of 0.7 nmol/l and 0.8 nmol/l, respectively, while had a ic50 value as low as 3.4 nmol/l when tested with rat factor xa [1].pre-treated anaesthetised rat model with intravenous 5-r-rivaroxaban at a dose of 2 mg/kg, and after bleeding initiated intravenous treated with rfviia (100/400 μg/kg), pcc (25/50 u/kg) or apcc (50/100 u/kg), the result showed that 5-r-rivaroxaban pre-treatment significantly shorten bleeding time and clotting time compared with 5-r-rivaroxaban alone treated group [2]. similar results were obtained when tested with rabbit model [1].it has been reported that 5-r-rivaroxaban is a promising drug for atrial fibrillation, venous thromboembolism or thromboembolic disorders in clinic [3] [4] [1].
References
[1]. perzborn, e., et al., rivaroxaban: a new oral factor xa inhibitor. arterioscler thromb vasc biol, 2010. 30(3): p. 376-81.
[2]. perzborn, e., et al., reversal of rivaroxaban anticoagulation by haemostatic agents in rats and primates. thromb haemost, 2013. 110(1): p. 162-72.
[3]. beyer-westendorf, j., et al., efficacy and safety of rivaroxaban or fondaparinux thromboprophylaxis in major orthopedic surgery: findings from the ortho-tep registry. j thromb haemost, 2012. 10(10): p. 2045-52.
[4]. palareti, g., et al., clinical management of rivaroxaban-treated patients. expert opin pharmacother, 2013. 14(5): p. 655-67.
5-R-Rivaroxaban Preparation Products And Raw materials
Raw materials
Preparation Products
Supplier | Tel | Country | ProdList | Advantage | |
---|---|---|---|---|---|
Henan Fengda Chemical Co., Ltd | +86-371-86557731 +86-13613820652 | info@fdachem.com | China | 20294 | 58 |
ATK CHEMICAL COMPANY LIMITED | +undefined-21-51877795 | ivan@atkchemical.com | China | 32760 | 60 |
Hubei Jusheng Technology Co.,Ltd. | 18871490254 | linda@hubeijusheng.com | CHINA | 28180 | 58 |
Standardpharm Co. Ltd. | 86-714-3992388 | overseasales1@yongstandards.com | United States | 14336 | 58 |
BOC Sciences | +1-631-485-4226 | inquiry@bocsci.com | United States | 19553 | 58 |
TargetMol Chemicals Inc. | +1-781-999-5354 +1-00000000000 | marketing@targetmol.com | United States | 19892 | 58 |
Career Henan Chemica Co | +86-0371-86658258 +8613203830695 | laboratory@coreychem.com | China | 30250 | 58 |
ANHUI WITOP BIOTECH CO., LTD | +8615255079626 | eric@witopchemical.com | China | 23556 | 58 |
Zhejiang J&C Biological Technology Co.,Limited | +1-2135480471 +1-2135480471 | sales@sarms4muscle.com | China | 10522 | 58 |
Hangzhou Huarong Pharm Co., Ltd. | 571-86758373 +8613588754946 | sales@huarongpharm.com | CHINA | 3149 | 58 |
View Lastest Price from 5-R-Rivaroxaban manufacturers
Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
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2024-04-25 | 5-R-Rivaroxaban
865479-71-6
|
US $8.00-2.00 / kg | 1kg | 99% | g-kg-tons, free sample is available | Henan Fengda Chemical Co., Ltd |
-
- 5-R-Rivaroxaban
865479-71-6
- US $8.00-2.00 / kg
- 99%
- Henan Fengda Chemical Co., Ltd
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