ChemicalBook >> CAS DataBase List >>(2R,3R,4R)-2-(6-aMino-9H-purin-9-yl)tetrahydrofuran-3,4-diol
(2R,3R,4R)-2-(6-aMino-9H-purin-9-yl)tetrahydrofuran-3,4-diol
- CAS No.
- 17019-46-4
- Chemical Name:
- (2R,3R,4R)-2-(6-aMino-9H-purin-9-yl)tetrahydrofuran-3,4-diol
- Synonyms
- Erythrofuranosyladenine;9-β-D-Erythrofuranosyladenine;(2R,3R,4R)-2-(6-aMino-9H-purin-9-yl)tetrahydrofuran-3,4-diol
- CBNumber:
- CB02648547
- Molecular Formula:
- C9H11N5O3
- Molecular Weight:
- 237.21534
- MDL Number:
- MFCD28016443
- MOL File:
- 17019-46-4.mol
Last updated:2023-03-31 09:12:58
(2R,3R,4R)-2-(6-aMino-9H-purin-9-yl)tetrahydrofuran-3,4-diol Chemical Properties,Uses,Production
Description
Erythrofuranosyladenine, also known as 9-beta-D-Erythrofuranosyladenine and ETA, is a nontoxic MTAP substrate. Erythrofuranosyladenine is an effective salvage agent for methylthioadenosine phosphorylase–selective therapy of T-cell acute lymphoblastic leukemia with L-alanosine. The cytotoxicity of EFA to hematopoietic progenitors erythroid burst-forming units (BFU-Es) and granulocyte-macrophage colony-forming units (CFU-GMs) was at least 26- to 41-fold less than that of MTA. EFA selectively rescued MTAP+ MOLT-4 cells from L-alanosine toxicity at 25 microM with negligible toxicity even at 100 microM. EFA is an effective agent for salvaging MTAP+ cells from L-alanosine toxicity and is superior to MTA due to lower cytotoxicity.
(2R,3R,4R)-2-(6-aMino-9H-purin-9-yl)tetrahydrofuran-3,4-diol Preparation Products And Raw materials
Raw materials
Preparation Products
(2R,3R,4R)-2-(6-aMino-9H-purin-9-yl)tetrahydrofuran-3,4-diol Suppliers
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TargetMol Chemicals Inc. | 58 |
(2R,3R,4R)-2-(6-aMino-9H-purin-9-yl)tetrahydrofuran-3,4-diol
9-β-D-Erythrofuranosyladenine
Erythrofuranosyladenine
17019-46-4