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XL 228

CAS No.
898280-07-4
Chemical Name:
XL 228
Synonyms
XL228;XL-228;XL 228;CS-1050;XL228, >=98%;XL228; XL 228;Inhibitor,Bcr-Abl,Aurora Kinase,Src,XL228,IGF-1R,inhibit,XL 228,XL-228;N4-(5-Cyclopropyl-1H-pyrazol-3-yl)-N2-((3-isopropylisoxazol-5-yl)methyl)-6-(4-methylpiperazin-1-yl)pyrimidine-2,4-diamine;N4-(5-Cyclopropyl-1H-pyrazol-3-yl)-N2-[[3-(1-methylethyl)-5-isoxazolyl]methyl]-6-(4-methyl-1-piperazinyl)-2,4-pyrimidinediamine;2,4-Pyrimidinediamine, N4-(5-cyclopropyl-1H-pyrazol-3-yl)-N2-[[3-(1-methylethyl)-5-isoxazolyl]methyl]-6-(4-methyl-1-piperazinyl)-
CBNumber:
CB02666701
Molecular Formula:
C22H31N9O
Molecular Weight:
437.54
MDL Number:
MFCD26793867
MOL File:
898280-07-4.mol
MSDS File:
SDS
Last updated:2024-07-02 08:54:57

XL 228 Properties

storage temp. Store at -20°C
solubility ≥21.9 mg/mL in DMSO; insoluble in H2O; ≥27.6 mg/mL in EtOH with gentle warming and ultrasonic
form solid
color White to off-white
FDA UNII 33M2XSK003

XL 228 price More Price(22)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Cayman Chemical 21506 XL228 ≥98% 898280-07-4 5mg $81 2024-03-01 Buy
Cayman Chemical 21506 XL228 ≥98% 898280-07-4 10mg $143 2024-03-01 Buy
Cayman Chemical 21506 XL228 ≥98% 898280-07-4 25mg $321 2024-03-01 Buy
Cayman Chemical 21506 XL228 ≥98% 898280-07-4 50mg $576 2024-03-01 Buy
TRC X746000 XL228 898280-07-4 100mg $625 2021-12-16 Buy
Product number Packaging Price Buy
21506 5mg $81 Buy
21506 10mg $143 Buy
21506 25mg $321 Buy
21506 50mg $576 Buy
X746000 100mg $625 Buy

XL 228 Chemical Properties,Uses,Production

Uses

XL228 is a multi-targeted protein kinase inhibitor in patients with solid tumors or multiple myeloma. It is a COVID19-related research product.

Biological Activity

xl228, a tyrosine kinase inhibitor, is involved in binding to and inhibiting the activities of multiple tyrosine kinases, such as the insulin-like growth factor 1 receptor (igf1r), src tyrosine kinase, and bcr-abl tyrosine kinase. blockade of these kinases may result in the inhibition of tumor angiogenesis, cell proliferation, and metastasis [1]. xl228 is a multitargeted protein kinase inhibitor targeting igf1r, the aurora kinases, igf-1r, csrc, bcr/abl and src kinases [2].

in vitro

xl228(5-100 nm) reduced cell survival by 10-70% in a dose and time dependent manner and inhibited migration and invasion of two tumors with high propensity to metastasize, fadu and h460. treatment with 50 and 100 nm xl228 abolished the ability of h460, a549 and fadu cells to form colony. at 10 nm, xl228 significantly increased the radiosensitivity of h460, a549 and fadu cells by enhancement factors (ef, at the survival fraction of 0.5) of 1.52, 1.31 and 1.67 respectively. but, in hn-5 cells, sensitization occurred only at 100 nm (ef = 2.27). in hn-5 cells, xl228 (100 nm)incubation induced accumulation of cells at the radiation sensitive g2/m phase of the cell cycle and induced apoptosis in 32% of cells [2].

References

[1] smith d c, britten c, garon e b. a phase i study of xl228, a multitargeted protein kinase inhibitor, in patients with solid tumors or multiple myeloma[j]. j clinoncol, 2010, 28(15s suppl: abstr 3105).
[2] matsumoto f, molkentine d, clary d o, et al. a multi-kinase inhibitor, xl228, enhanced human cancer cell radiosensitivity and suppressed cell invasion and migration[j]. cancer research, 2011, 71(8 supplement): 2487-2487.
[3] smith d c, britten c, clary d o, et al. a phase i study of xl228, a potent igf1r/aurora/src inhibitor, in patients with solid tumors or hematologic malignancies[j]. j clinoncol, 2009, 27(15 suppl): 149s.

XL 228 Preparation Products And Raw materials

Raw materials

Preparation Products

XL 228 Suppliers

Global( 61)Suppliers
Supplier Tel Email Country ProdList Advantage
Nanjing ChemLin Chemical Industry Co., Ltd.
025-83697070 product@chemlin.com.cn CHINA 3009 60
TargetMol Chemicals Inc.
+1-781-999-5354 +1-00000000000 marketing@targetmol.com United States 32161 58
Career Henan Chemica Co
+86-0371-86658258 +8613203830695 laboratory@coreychem.com China 30238 58
Henan Fengda Chemical Co., Ltd
+86-371-86557731 +86-13613820652 info@fdachem.com China 20284 58
Aladdin Scientific
+1-+1(833)-552-7181 sales@aladdinsci.com United States 57505 58
SHANGHAI KEAN TECHNOLOGY CO., LTD.
+8613817748580 cooperation@kean-chem.com China 40066 58
Amadis Chemical Company Limited
571-89925085 sales@amadischem.com China 131957 58
Shanghai Boyle Chemical Co., Ltd. sales@boylechem.com China 2922 55
Haoyuan Chemexpress Co., Ltd. 021-58950125 info@chemexpress.com China 7552 61
Shanghai Aladdin Bio-Chem Technology Co.,LTD 400-400-6206333 18521732826 market@aladdin-e.com China 25003 65

XL 228 Spectrum

XL228, >=98% XL 228 XL228 XL-228 N4-(5-Cyclopropyl-1H-pyrazol-3-yl)-N2-[[3-(1-methylethyl)-5-isoxazolyl]methyl]-6-(4-methyl-1-piperazinyl)-2,4-pyrimidinediamine XL228; XL 228 CS-1050 2,4-Pyrimidinediamine, N4-(5-cyclopropyl-1H-pyrazol-3-yl)-N2-[[3-(1-methylethyl)-5-isoxazolyl]methyl]-6-(4-methyl-1-piperazinyl)- Inhibitor,Bcr-Abl,Aurora Kinase,Src,XL228,IGF-1R,inhibit,XL 228,XL-228 N4-(5-Cyclopropyl-1H-pyrazol-3-yl)-N2-((3-isopropylisoxazol-5-yl)methyl)-6-(4-methylpiperazin-1-yl)pyrimidine-2,4-diamine 898280-07-4 C22H31N9O