ChemicalBook >> CAS DataBase List >>GSK3987

GSK3987

GSK3987 structure

CAS No.: 264206-85-1

Chemical Name:: GSK3987

Synonyms: GSK3987;LXRα/β Agonist;1-Benzyl-3-((4-methoxyphenyl)amino)-4-phenyl-1H-pyrrole-2,5-dione;GSK3987 1-benzyl-3-((4-methoxyphenyl)amino)-4-phenyl-1H-pyrrole-2,5-dione;1H-Pyrrole-2,5-dione, 3-[(4-methoxyphenyl)amino]-4-phenyl-1-(phenylmethyl)-;macrophages,GSK 3987,cellular cholesterol,inhibit,ABCA1,HepG2 cells,Inhibitor,SREBP-1c,LXR,Liver X receptor,triglyceride accumulation,GSK3987,GSK-3987

CBNumber:: CB02669287

Molecular Formula:: C24H20N2O3

Molecular Weight:: 384.43

MDL Number:

MOL File:: 264206-85-1.mol

Last updated:2024-07-02 08:54:57

Request For Quotation

GSK3987 Properties

Boiling point	572.4±50.0 °C(Predicted)
Density	1.309±0.06 g/cm3(Predicted)
storage temp.	-20°C
solubility	DMSO: 200 mg/ml,Methanol: 100 mg/ml
form	A solid
pka	-1.27±0.20(Predicted)
color	Light yellow to yellow

GSK3987 Chemical Properties,Uses,Production

Biological Activity

GSK3987 is a dual agonist of liver X receptor α (LXRα) and LXRβ.1 It recruits steroid receptor coactivator 1 (SRC-1) to LXRα and LXRβ in a ligand-sensing assay (LiSA; EC50s = 50 and 40 nM, respectively). GSK3987 is 50-fold selective for LXRα and LXRβ over a panel of nuclear receptors and GSK3β (IC50 = >5,000 nM) but does induce ABCA1 expression in a reporter assay using THP-1 cells (EC50 = 80 nM). It inhibits LPS-induced IL-6 secretion in THP-1 macrophages. GSK3987 increases the expression of the sterol regulatory element binding protein 1c (SREBP-1c) and induces triglyceride accumulation in HepG2 cells in a concentration-dependent manner.

References

1.Jaye, M.C., Krawiec, J.A., Campobasso, N., et al.Discovery of substituted maleimides as liver X receptor agonists and determination of a ligand-bound crystal structureJ. Med. Chem.48(17)5419-5422(2005)

GSK3987 synthesis

Synthesis of GSK3987 from 1H-Pyrrole-2,5-dione, 3-[(4-methoxyphenyl)amino]-4-phenyl- and Benzyl alcohol

GSK3987 Preparation Products And Raw materials

Raw materials

Preparation Products

GSK3987 Suppliers

Global( 25)Suppliers

Supplier	Tel	Email	Country	ProdList	Advantage
TargetMol Chemicals Inc.	+1-781-999-5354 +1-00000000000	marketing@targetmol.com	United States	19892	58
Nanjing Doge Biomedical Technology Co., Ltd	+86-25-58227606 +86-15305155328	sales@dogechemical.com	China	4128	58
Wuhan Topule Biopharmaceutical Co., Ltd	+8618327326525	masar@topule.com	China	8474	58
Shenyang Zhongshen Zekang Biomedical Technology Research Co., Ltd	+86-18341751992 +86-15382112998	757984502@qq.com	China	892	58
Aladdin Scientific	+1-+1(833)-552-7181	sales@aladdinsci.com	United States	52927	58
Wuhan Jingkang en Biomedical Technology Co., Ltd	+8613720134139	orders@jknbiochem.com	China	5225	58
Shanghai EFE Biological Technology Co., Ltd.	021-65675885 18964387627	info@efebio.com	China	9806	58
Shanghai Han-Xiang Chemical Co., Ltd.	15971444841	amber@biochempartner.com	China	3063	58
DC Chemicals	021-58447131 13564518121	sales@dcchemicals.com	China	9412	58
ChemeGen(Shanghai) Biotechnology Co.,Ltd.	18818260767	sales@chemegen.com	China	11289	58

Supplier	Advantage
TargetMol Chemicals Inc.	58
Nanjing Doge Biomedical Technology Co., Ltd	58
Wuhan Topule Biopharmaceutical Co., Ltd	58
Shenyang Zhongshen Zekang Biomedical Technology Research Co., Ltd	58
Aladdin Scientific	58
Wuhan Jingkang en Biomedical Technology Co., Ltd	58
Shanghai EFE Biological Technology Co., Ltd.	58
Shanghai Han-Xiang Chemical Co., Ltd.	58
DC Chemicals	58
ChemeGen(Shanghai) Biotechnology Co.,Ltd.	58

GSK3987 GSK3987 1-benzyl-3-((4-methoxyphenyl)amino)-4-phenyl-1H-pyrrole-2,5-dione macrophages,GSK 3987,cellular cholesterol,inhibit,ABCA1,HepG2 cells,Inhibitor,SREBP-1c,LXR,Liver X receptor,triglyceride accumulation,GSK3987,GSK-3987 1H-Pyrrole-2,5-dione, 3-[(4-methoxyphenyl)amino]-4-phenyl-1-(phenylmethyl)- LXRα/β Agonist 1-Benzyl-3-((4-methoxyphenyl)amino)-4-phenyl-1H-pyrrole-2,5-dione 264206-85-1