ChemicalBook >> CAS DataBase List >>Boronic acid, B-[(1S)-3-Methyl-1-[[(2R)-1-oxo-3-phenyl-2-[(2-pyrazinylcarbonyl)aMino]propyl]aMino]butyl]-

Boronic acid, B-[(1S)-3-Methyl-1-[[(2R)-1-oxo-3-phenyl-2-[(2-pyrazinylcarbonyl)aMino]propyl]aMino]butyl]-

CAS No.
1132709-16-0
Chemical Name:
Boronic acid, B-[(1S)-3-Methyl-1-[[(2R)-1-oxo-3-phenyl-2-[(2-pyrazinylcarbonyl)aMino]propyl]aMino]butyl]-
Synonyms
Bortizomib SR-OH;(1S,2R)-BortezoMib;Bortezomib (1R,2R)Isomer;Bortezomib S,R Enantiomer;Bortezomib (1S, 2R)-Isomer;(1S,2R)-Bortezomib Impurity;Bortezomib S,R-Isomer Impurity;Bortezomib impurities (R, S-isomer);Bortezomib Impurity (1S,2R - Isomer);Bortezomib impurity 2/(1S,2R)-Bortezomib
CBNumber:
CB02677165
Molecular Formula:
C19H25BN4O4
Molecular Weight:
384.24
MDL Number:
MFCD09749895
MOL File:
1132709-16-0.mol
Last updated:2023-05-15 10:43:59

Boronic acid, B-[(1S)-3-Methyl-1-[[(2R)-1-oxo-3-phenyl-2-[(2-pyrazinylcarbonyl)aMino]propyl]aMino]butyl]- Properties

Density 1.214±0.06 g/cm3(Predicted)
solubility Acetonitrile (Slightly), DMSO (Slightly), Methanol (Slightly)
pka 9.66±0.43(Predicted)
form Solid
color White to Off-White
Stability Hygroscopic, Light sensitive, Moisture sensitive

Boronic acid, B-[(1S)-3-Methyl-1-[[(2R)-1-oxo-3-phenyl-2-[(2-pyrazinylcarbonyl)aMino]propyl]aMino]butyl]- price

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
TRC B675710 (1S,2R)-Bortezomib 1132709-16-0 50mg $375 2021-12-16 Buy
Chemenu CM205039 ((S)-3-Methyl-1-((R)-3-phenyl-2-(pyrazine-2-carboxamido)propanamido)butyl)boronicacid 95%+ 1132709-16-0 100mg $668 2021-12-16 Buy
Product number Packaging Price Buy
B675710 50mg $375 Buy
CM205039 100mg $668 Buy

Boronic acid, B-[(1S)-3-Methyl-1-[[(2R)-1-oxo-3-phenyl-2-[(2-pyrazinylcarbonyl)aMino]propyl]aMino]butyl]- Chemical Properties,Uses,Production

Uses

(1S,3R)-Bortezomib is an diastereomer of Bortezomib (B675700), the first proteasome inhibitor to be approved by the US FDA for multiple myeloma, a blood cancer. A reversible inhibitor of the 26S proteasome-a barrel-shaped multiprotein particle found in the nucleus and cytosol of all eukaryotic cells. Targets the ubiquitin-proteasome pathway

Boronic acid, B-[(1S)-3-Methyl-1-[[(2R)-1-oxo-3-phenyl-2-[(2-pyrazinylcarbonyl)aMino]propyl]aMino]butyl]- Preparation Products And Raw materials

Raw materials

Preparation Products

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Boronic acid, B-[(1S)-3-Methyl-1-[[(2R)-1-oxo-3-phenyl-2-[(2-pyrazinylcarbonyl)aMino]propyl]aMino]butyl]- (1S,2R)-BortezoMib (S)-3-Methyl-1-((R)-3-phenyl-2-(pyrazine-2-carboxaMido)propanaMido)butylboronic acid N-(2-Pyrazinecarbonyl)-D-phenylalanine-D-leucine boronic anhydride Bortezomib Impurity (1S,2R - Isomer) Bortezomib impurity 2/(1S,2R)-Bortezomib Bortezomib (1R,2R)Isomer (1S,2R)-Bortezomib Impurity Bortezomib impurities (R, S-isomer) Bortezomib (1S, 2R)-Isomer (1s) - 3-methyl-1 - [(2R) - 1-oxo-3-phenyl-2 - [(pyrazinoyl) - amino] propyl] amino] butyl] boric acid Bortizomib SR-OH Bortezomib S,R-Isomer Impurity (1S,2R) BortezomibQ: What is (1S,2R) Bortezomib Q: What is the CAS Number of (1S,2R) Bortezomib Q: What is the storage condition of (1S,2R) Bortezomib Q: What are the applications of (1S,2R) Bortezomib Boronic acid, B-[(1S)-3-Methyl-1-[[(2R)-1-oxo-3-phenyl-2-[(2 Bortezomib S,R Enantiomer 1132709-16-0 Chiral Reagents, Boron Derivatives, Inhibitors, Pharmaceuticals, Intermediates & Fine Chemicals