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KN-93 Phosphate

KN-93 Phosphate structure

CAS No.: 1188890-41-6

Chemical Name:: KN-93 Phosphate

Synonyms: CS-1902;KN 93; KN93;KN-93PHOSPHATE;KN-93 phospate;(E)-KN-93 (phosphate);KN-93 phosphate, >=98%;KN 93 Phosphate (E-form);KN-93 Phosphate USP/EP/BP;(E)-N-(2-(((3-(4-Chlorophenyl)allyl)(methyl)amino)methyl)phenyl)-N-(2-hydroxyethyl)-4-methoxybenzenesulfonamide phosphate;N-[2-[[[3-(4-Chlorophenyl)-2-propenyl]methylamino]methyl]phenyl]-N-(2-hydroxyethyl)-4-methoxybenzenesulphonamide phosphate

CBNumber:: CB02729653

Molecular Formula:: C26H32ClN2O8PS

Molecular Weight:: 599.032641

MDL Number:: MFCD03788201

MOL File:: 1188890-41-6.mol

Last updated:2023-06-30 15:45:59

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KN-93 Phosphate Properties

storage temp.	Inert atmosphere,Room Temperature
solubility	DMF:25.0(Max Conc. mg/mL);41.73(Max Conc. mM) DMSO:76.67(Max Conc. mg/mL);127.98(Max Conc. mM) Water:49.33(Max Conc. mg/mL);82.35(Max Conc. mM)
form	White to off-white solid.
Water Solubility	Soluble in water (10mM)
CAS DataBase Reference	1188890-41-6

SAFETY

Risk and Safety Statements

Symbol(GHS)	GHS05
Signal word	Danger
Hazard statements	H314
Precautionary statements	P260-P264-P280-P301+P330+P331-P303+P361+P353-P304+P340-P305+P351+P338-P310-P363-P405-P501

KN-93 Phosphate price More Price(22)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
Cayman Chemical	21472	KN-93 (phosphate) ≥98%	1188890-41-6	1mg	$32	2024-03-01	Buy
Cayman Chemical	21472	KN-93 (phosphate) ≥98%	1188890-41-6	5mg	$116	2024-03-01	Buy
Cayman Chemical	21472	KN-93 (phosphate) ≥98%	1188890-41-6	10mg	$184	2024-03-01	Buy
Cayman Chemical	21472	KN-93 (phosphate) ≥98%	1188890-41-6	25mg	$343	2024-03-01	Buy
Tocris	5215	KN93phosphate ≥98%(HPLC)	1188890-41-6	1	$141	2021-12-16	Buy

Product number	Packaging	Price	Buy
21472	1mg	$32	Buy
21472	5mg	$116	Buy
21472	10mg	$184	Buy
21472	25mg	$343	Buy
5215	1	$141	Buy

KN-93 Phosphate Chemical Properties,Uses,Production

Description

KN-93 (phosphate) is a potent and selective inhibitor of Ca²⁺/calmodulin-dependent kinase II (CaMKII) (K_i = 370 nM), inhibiting both the α- and β-subunits of CaMKII. It does not have significant effects on cAMP-dependent protein kinase, Ca²⁺/phospholipid-dependent protein kinase, myosin light chain kinase, or Ca²⁺ phosphodiesterase activity. It inhibits histamine-induced aminopyrine uptake in parietal cells (IC₅₀ = 300 nM). KN-93 can block voltage-gated potassium (K_v) channels when applied extracellularly, independent of its CaMKII action. More recently, KN-93 has been used to implicate roles for CaMKII in Ca²⁺-induced Ca²⁺ release in cardiac myocytes, constitutive phosphorylation of 5-lipoxygenase in 3T3 cells, and Ca²⁺-dependent activation of HIF-1α in colon cancer cells.

Uses

KN 93 Phosphate is a potent and selective inhibitor of Ca2+/calmodulin-dependent protein kinase II.

storage

-20°C

KN-93 Phosphate Preparation Products And Raw materials

Raw materials

Preparation Products

KN-93 Phosphate Suppliers

Global( 67)Suppliers

Supplier	Tel	Email	Country	ProdList	Advantage
Nanjing ChemLin Chemical Industry Co., Ltd.	025-83697070	product@chemlin.com.cn	CHINA	3009	60
ATK CHEMICAL COMPANY LIMITED	+undefined-21-51877795	ivan@atkchemical.com	China	32957	60
Hubei Jusheng Technology Co.,Ltd.	18871490254	linda@hubeijusheng.com	CHINA	28172	58
Career Henan Chemica Co	+86-0371-86658258 +8613203830695	laboratory@coreychem.com	China	30240	58
Dideu Industries Group Limited	+86-29-89586680 +86-15129568250	1026@dideu.com	China	22783	58
InvivoChem	+1-708-310-1919 +1-13798911105	sales@invivochem.cn	United States	6391	58
ShenZhen Trendseen Biological Technology Co.,Ltd.	13417589054	trendseenbio@gmail.com	China	11681	58
LEAPCHEM CO., LTD.	+86-852-30606658	market18@leapchem.com	China	43340	58
Aladdin Scientific	+1-+1(833)-552-7181	sales@aladdinsci.com	United States	57505	58
Amadis Chemical Company Limited	571-89925085	sales@amadischem.com	China	131957	58

Supplier	Advantage
Nanjing ChemLin Chemical Industry Co., Ltd.	60
ATK CHEMICAL COMPANY LIMITED	60
Hubei Jusheng Technology Co.,Ltd.	58
Career Henan Chemica Co	58
Dideu Industries Group Limited	58
InvivoChem	58
ShenZhen Trendseen Biological Technology Co.,Ltd.	58
LEAPCHEM CO., LTD.	58
Aladdin Scientific	58
Amadis Chemical Company Limited	58

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KN-93PHOSPHATE Benzenesulfonamide, N-[2-[[[(2E)-3-(4-chlorophenyl)-2-propen-1-yl]methylamino]methyl]phenyl]-N-(2-hydroxyethyl)-4-methoxy-, phosphate (1:1) N-[2-[[[3-(4-Chlorophenyl)-2-propenyl]methylamino]methyl]phenyl]-N-(2-hydroxyethyl)-4- methoxybenzenesulphonamide phosphate KN-93 Phosphate KN-93 phosphate, >=98% KN-93 phospate N-[2-({[(2E)-3-(4-Chlorophenyl)-2-propen-1-yl](methyl)amino}methyl)phenyl]-N-(2-hydroxyethyl)-4-methoxybenzenesulfonamide phosphate (1:1) CS-1902 N-[2-[[[3-(4-Chlorophenyl)-2-propenyl]methylamino]methyl]phenyl]-N-(2-hydroxyethyl)-4-methoxybenzenesulphonamide phosphate KN 93; KN93 KN-93 Phosphate USP/EP/BP (E)-N-(2-(((3-(4-Chlorophenyl)allyl)(methyl)amino)methyl)phenyl)-N-(2-hydroxyethyl)-4-methoxybenzenesulfonamide phosphate (E)-KN-93 (phosphate) KN 93 Phosphate (E-form) N-[2-[[[(2E)-3-(4-chlorophenyl)-2-propen-1-yl]methylamino]methyl]phenyl]-N-(2-hydroxyethyl)-4-methoxy-benzenesulfonamide, monophosphate 1188890-41-6 C26H29ClN2O4SH3O4P C26H32ClN2O8PS Inhibitors