PD 0332991 HCl
- CAS No.
- 827022-32-2
- Chemical Name:
- PD 0332991 HCl
- Synonyms
- CS-365;PD 0332991 HCl;Palbociclib HCl;Palbociclib-025;Palbociclib-019-HCl;PD 0332991;PD-0332991;PD 0332991 hydrochloride;PD-0332991 (Palbociclib);PD 0332991 HCl USP/EP/BP;Palbociclib (hydrochloride)
- CBNumber:
- CB22593007
- Molecular Formula:
- C24H30ClN7O2
- Molecular Weight:
- 484
- MDL Number:
- MFCD22420809
- MOL File:
- 827022-32-2.mol
- MSDS File:
- SDS
storage temp. | = -70C |
---|---|
solubility | ≥14.48 mg/mL in H2O; ≥2.42 mg/mL in DMSO; ≥2.79 mg/mL in EtOH with gentle warming and ultrasonic |
form | Yellow liquid |
color | Light yellow to yellow |
FDA UNII | BKC4F3Q5XL |
SAFETY
Risk and Safety Statements
Symbol(GHS) | ![]() GHS07 |
---|---|
Signal word | Warning |
Hazard statements | H315-H319 |
Precautionary statements | P264-P280-P302+P352-P337+P313-P305+P351+P338-P362+P364-P332+P313 |
HS Code | 29399990 |
PD 0332991 HCl price More Price(28)
Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
---|---|---|---|---|---|---|---|
Sigma-Aldrich | 5.30487 | StemSelect PD 0332991 - CAS 827022-32-2 - Calbiochem | 827022-32-2 | 5mg | $142 | 2024-03-01 | Buy |
Cayman Chemical | 16273 | PD 0332991 (hydrochloride) ≥95% | 827022-32-2 | 1mg | $37 | 2024-03-01 | Buy |
Cayman Chemical | 16273 | PD 0332991 (hydrochloride) ≥95% | 827022-32-2 | 5mg | $108 | 2024-03-01 | Buy |
Cayman Chemical | 16273 | PD 0332991 (hydrochloride) ≥95% | 827022-32-2 | 10mg | $195 | 2024-03-01 | Buy |
Cayman Chemical | 16273 | PD 0332991 (hydrochloride) ≥95% | 827022-32-2 | 25mg | $353 | 2024-03-01 | Buy |
PD 0332991 HCl Chemical Properties,Uses,Production
Description
PD 0332991 is an orally active, selective inhibitor of the cyclin D kinases Cdk4 (IC50 = 11 nM) and Cdk6 (IC50= 16 nM) with no activity against a panel of 36 additional protein kinases. It has been reported to have antiproliferative activity against retinoblastoma-positive tumor cells, blocking retinoblastoma phosphorylation and inducing G1 arrest at nanomolar concentrations. PD 0332991 can inhibit the growth of certain ER-positive or HER2-amplified breast cancer cells (IC50s as low as 4 nM) and demonstrates synergy with tamoxifen and trastuzumab, respectively. PD 0332991 inhibition of Cdk4 activity has been used to demonstrate a role for insulin-activated cyclinD1-Cdk4 signaling in the control of glucose metabolism that is independent of cell cycle progression.
General Description
A cell-permeable, orally available and brain permeant, non-toxic pyridopyrimidinone compound that acts as a potent, selective, reversible, ATP competitive inhibitor of Cdk4 and Cdk6 (IC50 = 11, 9, and 15 nM for Cdk4/D1, Cdk4/D3 and Cdk6/D2, respectively). Hence, it reduces retinoblastoma protein phosphorylation at Ser780/Ser795 (IC50 = 66 nM in MDA-435 cells) and arrests cell cycle at G1 phase. Acts as a cytostatic agent, but does induce apoptotic cell death when used alone. However, it potentiates the cytotoxicity of dexamethasone (>Cat. No. 265005), bortezomib (>Cat. No. 504314), and tamoxifen (Cat. No. 579000) in estrogen receptor (ER)-positive cell lines. Exhibits only a trivial inhibitory activity towards Cdk2/E2, Cdk2/A, Cdk1/B and Cdk5/p25 in a 36-kinase panel (IC50 >10 μM). Improves endoderm differentiation of late G1-human embryonic stem cells expressing Smad2 or Smad3 (~ 750 nM) and further enhances endoderm differentiation into hepatic and pancreatic progenitor cells. Shown to regress the growth of human breast tumor xenografts in murine models (~150 mg/kg, p.o., daily).
Biochem/physiol Actions
Cell permeable: yes
target
CDK4/cyclin D1
References
[1] ivan diaz-padilla, lillian l. siu and ignacio duran. cyclin-dependent kinase inhibitors as potential targeted anticancer agents. invest new drugs. 2009, 27: 586–594.
[2] richard s finn, judy dering, dylan conklin, ondrej kalous, david j cohen, amrita j desai, charles ginther, mohammad atefi, isan chen, camilla fowst, gerret los and dennis j slamon. pd 0332991, a selective cyclin d kinase 4/6 inhibitor, preferentially inhibits proliferation of luminal estrogen receptor-positive human breast cancer cell lines in vitro. breast cancer research. 2009, 11: r77.
![571189-10-1](/StructureFile/ChemBookStructure22/GIF/CB51010568.gif)
![827022-32-2](/CAS/20150408/GIF/827022-32-2.gif)
PD 0332991 HCl Preparation Products And Raw materials
Raw materials
Preparation Products
Supplier | Tel | Country | ProdList | Advantage | |
---|---|---|---|---|---|
Henan Fengda Chemical Co., Ltd | +86-371-86557731 +86-13613820652 | info@fdachem.com | China | 20294 | 58 |
Henan Tianfu Chemical Co.,Ltd. | +86-0371-55170693 +86-19937530512 | info@tianfuchem.com | China | 21668 | 55 |
Hangzhou FandaChem Co.,Ltd. | 008657128800458; +8615858145714 | fandachem@gmail.com | China | 9332 | 55 |
Nanjing Finetech Chemical Co., Ltd. | 025-85710122 17714198479 | sales@fine-chemtech.com | CHINA | 885 | 55 |
ATK CHEMICAL COMPANY LIMITED | +undefined-21-51877795 | ivan@atkchemical.com | China | 32760 | 60 |
career henan chemical co | +86-0371-86658258 +8613203830695 | sales@coreychem.com | China | 29894 | 58 |
Biochempartner | 0086-13720134139 | candy@biochempartner.com | CHINA | 967 | 58 |
Jinan Shengqi pharmaceutical Co,Ltd | 86+18663751872 | christine@shengqipharm.com | CHINA | 491 | 58 |
BOC Sciences | +1-631-485-4226 | inquiry@bocsci.com | United States | 19553 | 58 |
Chongqing Chemdad Co., Ltd | +86-023-6139-8061 +86-86-13650506873 | sales@chemdad.com | China | 39916 | 58 |
View Lastest Price from PD 0332991 HCl manufacturers
Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
---|---|---|---|---|---|---|---|---|
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2024-03-25 | PD 0332991 HCl
827022-32-2
|
US $31.00-1.20 / kg | 1kg | 99% | g-kg-tons, free sample is available | Henan Fengda Chemical Co., Ltd | |
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2021-08-18 | PD 0332991 HCl USP/EP/BP
827022-32-2
|
US $1.10 / g | 1g | 99.9% | 100 Tons min | Dideu Industries Group Limited | |
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2019-07-06 | PD 0332991 HCl
827022-32-2
|
US $2.00 / kg | 1kg | 99% | ask | Career Henan Chemical Co |
-
- PD 0332991 HCl
827022-32-2
- US $31.00-1.20 / kg
- 99%
- Henan Fengda Chemical Co., Ltd
-
- PD 0332991 HCl USP/EP/BP
827022-32-2
- US $1.10 / g
- 99.9%
- Dideu Industries Group Limited
-
- PD 0332991 HCl
827022-32-2
- US $2.00 / kg
- 99%
- Career Henan Chemical Co
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