PD 0332991 HCl synthesis
- Product Name:PD 0332991 HCl
- CAS Number:827022-32-2
- Molecular formula:C24H30ClN7O2
- Molecular Weight:484
![4-{6-[8-CYCLOPENTYL-6-(1-ETHOXY-VINYL)-5-METHYL-7-OXO-7,8-DIHYDRO-PYRIDO[2,3-D]PYRIMIDIN-2-YLAMINO]-PYRIDIN-3-YL}-PIPERAZINE-1-CARBOXYLIC ACID TERT-BUTYL ESTER](/StructureFile/ChemBookStructure22/GIF/CB51010568.gif)
571189-10-1
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827022-32-2
195 suppliers
$28.00/1unit
Yield:827022-32-2 92%
Reaction Conditions:
with hydrogenchloride in dichloromethane at 0 - 20;
Steps:
3
EXAMPLE 3 Preparation of 6-ACETVL-8-CVCLOPENTVI-5-METHYL-2- (5-PIPERAZIN-1- EL-PVRIDIN-2-YLAMINO)- 8H-PVRIDOR2, 3-DLPYRIMIDIN-7-ONE HVDROCHLORIDE Hydrogen chloride gas was bubbled into an ice-bath cooled solution of 4- {6- [8- CYCLOPENTYL-6- (1-ETHOXY-VINYL)-5-METHYL-7-OXO-7, 8-dihydro-pyrido [2, 3-D] idin-2-ylamino]- PYRIDIN-3-YL}-PIPERAZINE-1-CARBOXYLIC acid tert-butyl ester (4.50 g, 0.00783 mol, prepared as in Example 2) in DCM (100 mL). The resulting suspension was stoppered and stirred at RT overnight, then diluted with diethyl ether (200 mL). The solid was collected by filtration, washed with diethyl ether, and dried to give the hydrochloride salt of 6-acetyl-8-cyclopentyl-5- METHYL-2- (5-PIPERAZIN-1-YL-PYRIDIN-2-YLAMINO)-8H-PYRIDO [2, 3-d] pyrimidin-7-one as a yellow solid (4. 01 g, 92 %).
References:
WO2005/5426,2005,A1 Location in patent:Page/Page column 22
571190-30-2
9 suppliers
$5.00/5mg
827022-32-2
195 suppliers
$28.00/1unit
![4-[6-(6-BROMO-8-CYCLOPENTYL-5-METHYL-7-OXO-7,8-DIHYDRO-PYRIDO[2,3-D]PYRIMIDIN-2-YLAMINO)-PYRIDIN-3-YL]-PIPERAZINE-1-CARBOXYLIC ACID TERT-BUTYL ESTER](/StructureFile/ChemBookStructure22/GIF/CB61010565.gif)
571188-82-4
165 suppliers
$45.00/25mg
827022-32-2
195 suppliers
$28.00/1unit
571188-59-5
527 suppliers
$13.00/1g
827022-32-2
195 suppliers
$28.00/1unit