OTS964
- CAS No.
- 1338545-07-5
- Chemical Name:
- OTS964
- Synonyms
- OTS964;CS-2531;OTS964 HCl;OTS964; OTS 964;OTS964+OTS964 HCl;OTS964 HYDROCHLORIDE;OTS964 hydrochloride, 10 mM in DMSO;(R)-9-(4-(1-(dimethylamino)propan-2-yl)phenyl)-8-hydroxy-6-methylthieno[2,3-c]quinolin-4(5H)-one;(R)-9-[4-[1-(Dimethylamino)propan-2-yl]phenyl]-8-hydroxy-6-methylthieno[2,3-c]quinolin-4(5H)-one Hydrochloride
- CBNumber:
- CB02737339
- Molecular Formula:
- C23H24N2O2S
- Molecular Weight:
- 392.51386
- MDL Number:
- MFCD28386220
- MOL File:
- 1338545-07-5.mol
- MSDS File:
- SDS
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|---|---|
| Signal word | Warning |
| Hazard statements | H302-H315-H319-H335 |
| Precautionary statements | P261-P305+P351+P338 |
| HS Code | 2934999090 |
OTS964 price More Price(23)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Cayman Chemical | 17052 | OTS964 (hydrochloride) | 1338545-07-5 | 1mg | $92 | 2024-03-01 | Buy |
| Cayman Chemical | 17052 | OTS964 (hydrochloride) | 1338545-07-5 | 5mg | $168 | 2024-03-01 | Buy |
| Cayman Chemical | 17052 | OTS964 (hydrochloride) | 1338545-07-5 | 500μg | $49 | 2024-03-01 | Buy |
| TRC | O712970 | OTS964 | 1338545-07-5 | 25mg | $1175 | 2021-12-16 | Buy |
| TRC | O712970 | OTS964 | 1338545-07-5 | 10mg | $590 | 2021-12-16 | Buy |
OTS964 Chemical Properties,Uses,Production
Description
OTS964 is an inhibitor of lymphokine-activated killer T cell-originated protein kinase (TOPK; IC50 = 28 nM). It specifically blocks cytokinesis, leading to apoptosis, in a broad range of cancer cells. OTS964 induces apoptosis of human lung cancer cells in mouse xenografts.
Uses
OTS 964 works through cytokinesis and is an effective TOPK inhibitor which has been shown to cause tumor suppression in xenografts of human cancer.
in vivo
OTS964 hydrochloride (intravenously; 40 mg/kg on days 1, 4, 8, 11, 15, and 18) makes tumors shrinking even after the treatment and finally revealing complete regression[1].
OTS964 hydrochloride (oral administration; 50 or 100 mg/kg/day for 2 weeks) ultimately achieves complete tumor regression[1].
| Animal Model: | Nude mice bearing LU-99 lung cancer cells[1] |
| Dosage: | 40 mg/kg |
| Administration: | Intravenously; on days 1, 4, 8, 11, 15, and 18 |
| Result: | The tumors continued shrinking even after the treatment and finally revealed complete regression. |
| Animal Model: | Nude mice bearing LU-99 lung cancer cells[1] |
| Dosage: | 50 or 100 mg/kg |
| Administration: | Oral administration; once every day for 2 weeks |
| Result: | Achieved complete tumor regression. |
IC 50
TOPK: 28 nM (IC50); CDK11B: 40 nM (Kd)
References
1. matsuo y, park jh2, miyamoto t, et al. topk inhibitor induces complete tumor regression in xenograft models of human cancer through inhibition of cytokinesis. ci transl med. 2014 oct 22;6(259):259ra145.
OTS964 Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| ATK CHEMICAL COMPANY LIMITED | +undefined-21-51877795 | ivan@atkchemical.com | China | 33024 | 60 |
| BOC Sciences | +1-631-485-4226 | inquiry@bocsci.com | United States | 19552 | 58 |
| TargetMol Chemicals Inc. | +1-781-999-5354 +1-00000000000 | marketing@targetmol.com | United States | 32159 | 58 |
| HANGZHOU CLAP TECHNOLOGY CO.,LTD | 86-571-88216897,88216896 13588875226 | sales@hzclap.com | CHINA | 6312 | 58 |
| Chemia Biotechnology（Shanghai） Co., Ltd | +8613816753574 | info@chemia-pharm.com | CHINA | 311 | 58 |
| Zhejiang J&C Biological Technology Co.,Limited | +1-2135480471 +1-2135480471 | sales@sarms4muscle.com | China | 10473 | 58 |
| InvivoChem | +1-708-310-1919 +1-13798911105 | sales@invivochem.cn | United States | 6391 | 58 |
| Nantong HI-FUTURE Biology Co., Ltd. | +undefined18051384581 | sales@chemhifuture.com | China | 3135 | 58 |
| TargetMol Chemicals Inc. | support@targetmol.com | United States | 38630 | 58 | |
| ShenZhen Trendseen Biological Technology Co.,Ltd. | 13417589054 | trendseenbio@gmail.com | China | 11681 | 58 |
View Lastest Price from OTS964 manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2024-11-17 | OTS964 hydrochloride
1338545-07-5
|
US $38.00-85.00 / mg | 98.02% | 10g | TargetMol Chemicals Inc. |
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- OTS964 hydrochloride
1338545-07-5
- US $38.00-85.00 / mg
- 98.02%
- TargetMol Chemicals Inc.