Estradiol valerate
- CAS No.
- 979-32-8
- Chemical Name:
- Estradiol valerate
- Synonyms
- delestrogen;β-Estradiol 17-valerate;Nuvelle;femogex;pharlon;estraval;Climaval;Valergen;deladiol;atladiol
- CBNumber:
- CB0300193
- Molecular Formula:
- C23H32O3
- Molecular Weight:
- 356.51
- MDL Number:
- MFCD00056541
- MOL File:
- 979-32-8.mol
| Melting point | 144°C |
|---|---|
| Boiling point | 438.83°C (rough estimate) |
| Density | 1.1024 (rough estimate) |
| refractive index | 1.4700 (estimate) |
| storage temp. | Sealed in dry,Room Temperature |
| solubility | Practically insoluble in water, soluble in alcohol. |
| pka | 10.25±0.60(Predicted) |
| form | Solid |
| color | White to off-white |
| Merck | 13,3738 |
| BRN | 2480357 |
| InChI | InChI=1/C23H32O3/c1-3-4-5-22(25)26-21-11-10-20-19-8-6-15-14-16(24)7-9-17(15)18(19)12-13-23(20,21)2/h7,9,14,18-21,24H,3-6,8,10-13H2,1-2H3/t18-,19-,20+,21+,23+/s3 |
| InChIKey | RSEPBGGWRJCQGY-RBRWEJTLSA-N |
| SMILES | C[C@]12CC[C@]3([H])C4C=CC(O)=CC=4CC[C@@]3([H])[C@]1([H])CC[C@@H]2OC(=O)CCCC |&1:1,4,15,17,21,r| |
| CAS DataBase Reference | 979-32-8(CAS DataBase Reference) |
| FDA UNII | OKG364O896 |
| NCI Drug Dictionary | estradiol valerate |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |   GHS08,GHS09 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H351-H361fd-H362-H410 | |||||||||
| Precautionary statements | P202-P260-P263-P264-P273-P308+P313 | |||||||||
| Hazard Codes | T | |||||||||
| Risk Statements | 60-61 | |||||||||
| Safety Statements | 53-45 | |||||||||
| WGK Germany | 3 | |||||||||
| RTECS | KG5793000 | |||||||||
| HS Code | 29372390 | |||||||||
| NFPA 704 |
|
Estradiol valerate price More Price(25)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | PHR2857 | Estradiol Valerate certified reference material, pharmaceutical secondary standard | 979-32-8 | 200MG | $243 | 2024-03-01 | Buy |
| Sigma-Aldrich | E1631 | β-Estradiol 17-valerate ≥98% | 979-32-8 | 1g | $219 | 2024-03-01 | Buy |
| Sigma-Aldrich | 1254009 | Estradiol valerate United States Pharmacopeia (USP) Reference Standard | 979-32-8 | 100mg | $436 | 2024-03-01 | Buy |
| Cayman Chemical | 22221 | β-Estradiol 17-valerate ≥98% | 979-32-8 | 500mg | $81 | 2024-03-01 | Buy |
| Cayman Chemical | 22221 | β-Estradiol 17-valerate ≥98% | 979-32-8 | 1g | $129 | 2024-03-01 | Buy |
Estradiol valerate Chemical Properties,Uses,Production
Description
Estradiol valerate (EV), sold for use by mouth under the brand name Progynova and for use by injection under the brand names Delestrogen and Progynon Depot among others, is an estrogen medication. In women, it is used in hormone therapy for menopausal symptoms and low estrogen levels, hormone therapy for transgender women, and in hormonal birth control. It is also used in the treatment of prostate cancer in men. The medication is taken by mouth or by injection into muscle or fat once every 1 to 4 weeks.
Chemical Properties
White to off-white crystalline powder, odorless. Insoluble in water, easily soluble in ethanol, acetone, chloroform, slightly soluble in vegetable oil.
Originator
Delestrogen,Squibb,US,1954
Uses
Estradiol valerate is a female hormone (estrogen). It is used to reduce symptoms of menopause which are vaginal dryness, hot flashes, and others. The symptoms of menopause manifest because the body is making less estrogen; with estradiol valerate, these symptoms are brought to the lowest minimum. This medication therapy can also produce enough estrogen in women with ovarian failure, hypogonadism and can be used by men to treat prostate cancer (palliation only).
Definition
ChEBI: Estradiol valerate is a steroid ester. It is the parenterally-administered synthetic valerate ester of estradiol, a steroid sex hormone vital to the maintenance of fertility and secondary sexual characteristics in females.
Indications
Estradiol valerate is commercially available as an intramuscular injection as the product Delestrogen and is indicated for the treatment of moderate to severe vasomotor symptoms and vulvovaginal atrophy due to menopause, for the treatment of hypoestrogenism due to hypogonadism, castration or primary ovarian failure, and for the treatment of advanced androgen-dependent carcinoma of the prostate (for palliation only). Estradiol valerate is also available in combination with Dienogest as the commercially available product Natazia used for the prevention of pregnancy and for the treatment of heavy menstrual bleeding.
Manufacturing Process
2.3 parts of estradiol are mixed with 12 parts of pyridine and 10 parts of nvaleric anhydride and the mixture is heated for some time at 115°C in the oil
bath. The cooled solution is mixed with 250 parts of water, whereupon an oil
separates; this is extracted with ether. The separated ethereal solution is
washed successively with N sulfuric acid, water, N sodium carbonate solution
and water and then dried. The ether is then removed and the residue purified
by distillation in a high vacuum. The estradiol di-n-valerate forms a yellowish
oil according to US Patent 2,205,627.
1 part of estradiol-3,17-n-divalerianate (boiling point at 0.01 mm = 220° to
230°C bath temperature; made, e.g., by the action of n-valeric anhydride on a
solution of estradiol in pyridine) is mixed with 50 parts of a solution of 0.5%
strength of potassium carbonate in methyl alcohol of 95% strength, and the
whole is stirred for some time at 20°C. The oily n-di-valerianate passes gradually into solution. The solution is neutralized and the precipitate is
produced by the addition of about 200 parts of water. This finely crystalline
product is filtered and washed successively with water, dilute sodium
carbonate solution and again with water. It may be further purified by
crystallization from a mixture of methyl alcohol and water. The estradiol-17-
mono-n-valerianate melts at 144° to 145°C according to US Patent 2,233,025.
brand name
Delestrogen (King).
Therapeutic Function
Estrogen
General Description
Estradiol valerate is a synthetic hormone that is extensively metabolized to estradiol and valeric acid before reaching the systemic circulation. It is well suited for treatment of the characteristic symptoms accompanying menopause in women.
Side effects
As with all pharmaceutical medicines, some unwanted effects can occur from the use of estradiol valerate tablets.
Always consult a physician for medical advice before use.
Common side effects may include: bloating, vomiting, nausea, breast tenderness, headache, weight changes, and mood changes.
More severe side effects may include mental changes, breast lumps, vaginal bleeding, liver damage, increased thirst, and sudden vision loss.
Safety Profile
Suspected carcinogen with carcinogenic and teratogenic data. Experimental reproductive effects. When heated to decomposition it emits acrid smoke and irritating fumes. See also ESTRADIOL.
Estradiol valerate Preparation Products And Raw materials
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Hebei Bonster Technology Co.,Limited | +8613315996897 | bsterltd.wendy@gmail.com | China | 792 | 58 |
| Anhui Yiao New Material Technology Co., Ltd | +86-18033737140 +86-17354101231 | sales1@hbganmiao.com | China | 227 | 58 |
| Lewoo Pharmatech(Shanghai)Co.,Ltd | +86-15800805830 +86-15800805830 | miao@lewoopharma.com.cn | China | 184 | 58 |
| Shaanxi Dideu Medichem Co. Ltd | +86-29-81148696 +86-15536356810 | 1022@dideu.com | China | 3882 | 58 |
| Hebei Lingding Biotechnology Co., Ltd. | +86-18031140164 +86-19933155420 | erin@hbldbiotech.com | China | 31 | 58 |
| Hong Kong Excellence Biotechnology Co., Ltd. | ada@sh-teruiop.com | China | 875 | 58 | |
| Wuhan Haorong Biotechnology Co.,ltd | +86-18565342920; +8618565342920 | sales@chembj.net | China | 289 | 58 |
| Anhui Ruihan Technology Co., Ltd | +8617756083858 | daisy@anhuiruihan.com | China | 973 | 58 |
| Nantong Guangyuan Chemicl Co,Ltd | +undefined17712220823 | admin@guyunchem.com | China | 615 | 58 |
| Sigma Audley | +86-15937194204 +86-18126314766 | nova@sh-teruiop.com | China | 467 | 58 |
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View Lastest Price from Estradiol valerate manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2024-11-21 | Estradiol valerate
979-32-8
|
US $0.00-0.00 / Kg/Drum | 1KG | 98%-102%; USP | 500 KG | WUHAN FORTUNA CHEMICAL CO., LTD | |
 |
2024-11-21 | Estradiol valerate
979-32-8
|
US $100.00-75.00 / kg | 1kg | 99% | 5000Ton | HEBEI SHENGSUAN CHEMICAL INDUSTRY CO.,LTD | |
 |
2024-11-14 | Estradiol valerate
979-32-8
|
US $100.00 / KG | 1KG | 99% | 1 T | Hebei Lingding Biotechnology Co., Ltd. |
-
- Estradiol valerate
979-32-8
- US $0.00-0.00 / Kg/Drum
- 98%-102%; USP
- WUHAN FORTUNA CHEMICAL CO., LTD
-
- Estradiol valerate
979-32-8
- US $100.00-75.00 / kg
- 99%
- HEBEI SHENGSUAN CHEMICAL INDUSTRY CO.,LTD
-
- Estradiol valerate
979-32-8
- US $100.00 / KG
- 99%
- Hebei Lingding Biotechnology Co., Ltd.