perampanel 3/4 hydrate
- CAS No.
- 1571982-04-1
- Chemical Name:
- perampanel 3/4 hydrate
- Synonyms
- Perampanel Hydrate;4 hydrate;perampanel 3;Perampanel 3/4H2O;perampanel 3/4 hydrate;Perampanel hydrate (4:3);3-(2-CYANOPHENYL)-1-PHENYL-5-(2-PYRIDYL)-1,2-DIHYDROPYRIDIN-2-ONE 3/4 HYDRATE;2-(1',6'-Dihydro-6'-oxo-1'-phenyl[2,3'-bipyridin]-5'-yl)benzonitrile hydrate (4:3)
- CBNumber:
- CB03059139
- Molecular Formula:
- C23H17N3O2
- Molecular Weight:
- 367.41
- MDL Number:
- MOL File:
- 1571982-04-1.mol
| FDA UNII | 8LIX22217M |
|---|
perampanel 3/4 hydrate Chemical Properties,Uses,Production
Definition
ChEBI: Perampanel hydrate is a hydrate obtained by combining four molecules of perampanel with three molecules of water. Used as an adjunctive therapy for the treatment of partial-onset seizures in patients with epilepsy. It has a role as an AMPA receptor antagonist and an anticonvulsant. It contains a perampanel.
Clinical Use
Perampanel is a selective, non-competitive α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid receptor (AMPAR) antagonist approved for partial-onset seizures in patients with epilepsy. Perampanel was discovered and developed by Eisai.
Synthesis
A number of synthetic routes to perampanel have been reported and the process scale route is described herein.Bromination of commercial 2-methoxypyridine (120) gave 5-bromo-2-methoxypridine 121 in 86% yield (the scheme). Lithium halogen exchange was then accomplished by treating 121 with nbutyllithium followed by reaction with 2-benzenesulfonylpyridine (122) to provide bi-aryl 123 which was hydrolyzed under acidic conditions to give pyridine 124 in 60% overall yield. N-Arylation with triphenylboroxine (125) in the presence of copper acetate afforded N-aryl pyridine 126 in 91% yield. Pyridone 126 was reacted with N-bromosuccinimide to give bromopyridine 127 which was coupled with 2-(1,3,2-dioxaborinan-2-yl)benzonitrile (128) under palladium catalyzed conditions to give perampanel hydrate (XIX) in 86% yield after recrystallization from acetone/H2O.
perampanel 3/4 hydrate Preparation Products And Raw materials
Raw materials
Preparation Products
perampanel 3/4 hydrate Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
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