perampanel 3/4 hydrate
|
|
perampanel 3/4 hydrate 속성
안전
perampanel 3/4 hydrate C화학적 특성, 용도, 생산
Clinical Use
Perampanel is a selective, non-competitive α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid receptor (AMPAR) antagonist approved for partial-onset seizures in patients with epilepsy. Perampanel was discovered and developed by Eisai.Synthesis
A number of synthetic routes to perampanel have been reported and the process scale route is described herein.Bromination of commercial 2-methoxypyridine (120) gave 5-bromo-2-methoxypridine 121 in 86% yield (the scheme). Lithium halogen exchange was then accomplished by treating 121 with nbutyllithium followed by reaction with 2-benzenesulfonylpyridine (122) to provide bi-aryl 123 which was hydrolyzed under acidic conditions to give pyridine 124 in 60% overall yield. N-Arylation with triphenylboroxine (125) in the presence of copper acetate afforded N-aryl pyridine 126 in 91% yield. Pyridone 126 was reacted with N-bromosuccinimide to give bromopyridine 127 which was coupled with 2-(1,3,2-dioxaborinan-2-yl)benzonitrile (128) under palladium catalyzed conditions to give perampanel hydrate (XIX) in 86% yield after recrystallization from acetone/H2O.
perampanel 3/4 hydrate 준비 용품 및 원자재
원자재
준비 용품
perampanel 3/4 hydrate 공급 업체
글로벌( 20)공급 업체
| 공급자 | 전화 | 이메일 | 국가 | 제품 수 | 이점 |
|---|---|---|---|---|---|
| Chemsigma International Co., Ltd. | +86-18136843612 +86-19951791336 |
info@chemsigma.com | China | 1229 | 58 |
| Hangzhou Proserre Chemical Co.,Ltd. | +86-571-86088112 |
info@proserre.com | China | 1077 | 58 |
| Nanjing Doge Biomedical Technology Co., Ltd | +86-25-58227606 +86-15305155328 |
sales@dogechemical.com | China | 4128 | 58 |
| Lynnchem | 86-(0)29-85992781 17792393971 |
info@lynnchem.com | China | 4587 | 58 |
| Hubei Yangxin Medical Technology Co., Ltd. | 15374522761 |
3003392093@qq.com | China | 8259 | 55 |
| Shanghai Witofly Chemical Co. ,Ltd. | 021-021-50630626 18964684208 |
sales@witofly.com | China | 1598 | 55 |
| Novachemistry | 44-20819178-90 02081917890 |
info@novachemistry.com | United Kingdom | 4381 | 58 |
| Hunan chemfish Scientific co.,ltd | 0731-85567275 15528049369 |
sales@chemfish.com | China | 4959 | 58 |
| HUNAN CHEMFISH SCIENTIFIC CO.,LTD | +86-0731-85567275 13021512891 |
sales02@chemfish.com | China | 7868 | 58 |
| Shanghai Taijilin Industrial Co., Ltd. | 021-021-50630626 18964684208 |
kate@tajilin.com | China | 1222 | 58 |