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Deferiprone

Deferiprone Structure
Deferiprone structure
CAS No.
30652-11-0
Chemical Name:
Deferiprone
Synonyms
L1;CP20;DMHP;Kelfer;Deferrone;DEFERIPRON;DEFERIDONE;eferiprone;DEFERIPRONE;Deferiprone CRS
CBNumber:
CB0308124
Molecular Formula:
C7H9NO2
Molecular Weight:
139.15
MDL Number:
MFCD00134497
MOL File:
30652-11-0.mol
MSDS File:
SDS
Last updated:2024-11-19 20:33:22
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Deferiprone Properties

Melting point 272-275 °C (lit.)
Boiling point 255.1°C (rough estimate)
Density 1.1997 (rough estimate)
refractive index 1.4800 (estimate)
storage temp. 2-8°C
solubility Soluble in Water (up to 5 mg/ml with warming).
form Crystalline Powder or Needles
pka pKa1 3.3, pKa2 9.7(at 25℃)
color White to off-white
Water Solubility Soluble in hot water
Merck 14,2859
Stability Stable for 1 year from date of purchase as supplied. Solutions are not stable and must be prepared fresh daily.
InChI InChI=1S/C7H9NO2/c1-5-7(10)6(9)3-4-8(5)2/h3-4,10H,1-2H3
InChIKey TZXKOCQBRNJULO-UHFFFAOYSA-N
SMILES C1(C)N(C)C=CC(=O)C=1O
CAS DataBase Reference 30652-11-0(CAS DataBase Reference)
FDA UNII 2BTY8KH53L
NCI Drug Dictionary deferiprone
ATC code V03AC02

Pharmacokinetic data

Excreted unchanged in urine 15 - See 'Other information'.%
Volume of distribution 1.55-1.73(L/kg)
Biological half-life 2-3 / Unknown

SAFETY

Risk and Safety Statements

Symbol(GHS)  GHS hazard pictograms
GHS07
Signal word  Warning
Hazard statements  H302
Precautionary statements  P301+P312+P330
Hazard Codes  Xn
Risk Statements  22-36/37/38
Safety Statements  26-36-37/39
WGK Germany  3
RTECS  UU7785940
HS Code  29333990
Hazardous Substances Data 30652-11-0(Hazardous Substances Data)
Toxicity LD50 i.p. in rats, mice: 650 mg/kg, 0.8-1.0 g/kg; i.g. in rats: 2.0-3.0 g/kg (Kontoghiorghes, 1995)
NFPA 704
0
2 0

Deferiprone price More Price(31)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich 379409 3-Hydroxy-1,2-dimethyl-4(1H)-pyridone 98% 30652-11-0 5g $76.8 2024-03-01 Buy
Sigma-Aldrich 379409 3-Hydroxy-1,2-dimethyl-4(1H)-pyridone 98% 30652-11-0 25g $233 2024-03-01 Buy
TCI Chemical H0944 3-Hydroxy-1,2-dimethyl-4(1H)-pyridone >98.0%(T) 30652-11-0 5g $80 2024-03-01 Buy
TCI Chemical H0944 3-Hydroxy-1,2-dimethyl-4(1H)-pyridone >98.0%(T) 30652-11-0 25g $230 2024-03-01 Buy
Cayman Chemical 20387 Deferiprone ≥95% 30652-11-0 1g $32 2024-03-01 Buy
Product number Packaging Price Buy
379409 5g $76.8 Buy
379409 25g $233 Buy
H0944 5g $80 Buy
H0944 25g $230 Buy
20387 1g $32 Buy

Deferiprone Chemical Properties,Uses,Production

Description

Deferiprone is a lipophilic iron chelator that binds to iron at a molar ratio of 3:1 (ligand: iron). Its active form is available orally, making it the only oral iron chelator. Deferiprone is a member of the 4-pyridone family and is a pyridine 4-4 (1H) -one, with a methyl substitution at positions 1 and 2 and a hydroxyl substitution at position 3. By binding to iron, Deferiprone can remove excess iron from the body and prevent serum iron overload in patients with transfusion-dependent thalassemia. It has chelation and protective effects and is primarily used to treat thalassaemia.

Chemical Properties

White Needles

Originator

Cipla (India)

Uses

3-Hydroxy-1,2-dimethyl-4(1H)-pyridone (OH-pyridone) may be used in the bacterial killing assays. It has been employed as hydroxyketone chelating agent and its cytotoxic action against oral human normal and tumor cell lines has been evaluated.

Uses

A chelator that could replace disferrioxamine. It is orally and parenterally effective in the removal of iron in vivo from rabbits and mice and also from transferrin and ferritin in vitro

Definition

ChEBI: Deferiprone is a member of the class of 4-pyridones that is pyridin-4(1H)-one substituted at positions 1 and 2 by methyl groups and at position 3 by a hydroxy group. A lipid-soluble iron-chelator used for treatment of thalassaemia. It has a role as an iron chelator and a protective agent.

brand name

Kelfer

General Description

3-Hydroxy-1,2-dimethyl-4(1H)-pyridone (Hdpp, Deferiprone) is a hydroxy ketone derivative. It reacts with uranyl salts [UO2(NO3)2] in aqueous acidic solution to afford mono nuclear complexes ([UO2(dpp)(Hdpp)2(H2O)]ClO4). X-ray studies have been conducted to examine the structure and geometry of these complexes.

Clinical Use

Orally administered chelator:
Treatment of transfusional iron overload

Metabolism

Deferiprone is hepatically metabolised to an inactive glucuronide metabolite and is excreted mainly in the urine as the metabolite and the iron-deferiprone complex, with a small amount of unchanged drug.

References

1) Hider and Hoffbrand (2018),?The Role of Deferiprone in Iron Chelation; N. Engl. J. Med.,?379?2140 2) Sripetchwandee?et al.?(2016),?A combination of an iron chelator with an antioxidant effectively diminishes the dendritic loss, tau-hyperphosphorylation, amyloid-β accumulation and brain mitochondrial dynamic disruption in rats with chronic iron-overload., Neuroscience?332?191 3) Liu?et al.?(2018),?Iron and Alzheimer’s Disease: From Pathogenesis to Therapeutic Implications;?Front. Neurosci,?12?632

Deferiprone synthesis

118-71-8
30652-11-0
Synthesis of Deferiprone from 3-Hydroxy-2-methyl-4H-pyran-4-one

Deferiprone Preparation Products And Raw materials

Raw materials

4(1H)-Pyridinone, 3-hydroxy-1,2-dimethyl-, acetate (1:1) 3-(benzyloxy)-1,2- dimethylpyridin-4(1H)-one 1-(3-hydroxy-2-furyl)ethanone Methylamine 3-(BENZYLOXY)-2-METHYL-4H-PYRAN-4-ONE
3-Hydroxy-2-methyl-4H-pyran-4-one Iron Galactosylisomaltol Methylamine hydrochloride Acetic acid

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Preparation Products

D-glucose

Deferiprone Suppliers

Global( 327)Suppliers
Supplier Tel Email Country ProdList Advantage
Taizhou Creating Bio-pharm co., ltd.
+8613586099526 post@creatingbiopharm.com China 217 58
Hebei Weibang Biotechnology Co., Ltd 		+8615531157085 abby@weibangbio.com China 8807 58
Henan Research New Materials Co., Ltd. 		+8618903931531 sales018@researchvip.com China 179 58
shandong perfect biotechnology co.ltd 		+86-53169958659 +86-13153181156 sales@sdperfect.com China 294 58
Shanghai Daken Advanced Materials Co.,Ltd 		+86-371-66670886 info@dakenam.com China 18751 58
Henan Tianfu Chemical Co.,Ltd. 		+86-0371-55170693 +86-19937530512 info@tianfuchem.com China 21634 55
Hangzhou FandaChem Co.,Ltd. 		+8615858145714 FandaChem@Gmail.com China 8946 55
career henan chemical co 		+86-0371-86658258 +8613203830695 sales@coreychem.com China 29880 58
Hainan Xiyuan Chemical Technology Co., Ltd. 		+86-15008981366 15008981366@163.com CHINA 9 58
Accela ChemBio Inc. 		+1-858-6993322 info@accelachem.com United States 17836 58
Supplier Advantage
Taizhou Creating Bio-pharm co., ltd.
58
Hebei Weibang Biotechnology Co., Ltd 		58
Henan Research New Materials Co., Ltd. 		58
shandong perfect biotechnology co.ltd 		58
Shanghai Daken Advanced Materials Co.,Ltd 		58
Henan Tianfu Chemical Co.,Ltd. 		55
Hangzhou FandaChem Co.,Ltd. 		55
career henan chemical co 		58
Hainan Xiyuan Chemical Technology Co., Ltd. 		58
Accela ChemBio Inc. 		58

Related articles

View Lastest Price from Deferiprone manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
3-Hydroxy-1,2-dimethyl-4(1H)-pyridone pictures 2024-11-26 3-Hydroxy-1,2-dimethyl-4(1H)-pyridone
30652-11-0
 US $0.00-0.00 / Kg 1Kg 99% 1000kg Henan Research New Materials Co., Ltd.
Deferiprone pictures 2024-11-19 Deferiprone
30652-11-0
 US $42.00 / mg ≥95% 10g TargetMol Chemicals Inc.
Deferiprone pictures 2024-11-19 Deferiprone
30652-11-0
 US $0.00-0.00 / KG 1KG 98% HPLC 5 ton shandong perfect biotechnology co.ltd
  • Deferiprone pictures
  • Deferiprone
    30652-11-0
  • US $42.00 / mg
  • ≥95%
  • TargetMol Chemicals Inc.
  • Deferiprone pictures
  • Deferiprone
    30652-11-0
  • US $0.00-0.00 / KG
  • 98% HPLC
  • shandong perfect biotechnology co.ltd

Deferiprone Spectrum

Deferiprone(30652-11-0)MSDeferiprone(30652-11-0)1HNMRDeferiprone(30652-11-0)13CNMRDeferiprone(30652-11-0)RamanDeferiprone(30652-11-0)IR

30652-11-0(Deferiprone)Related Search:

Deferiprone 4-HYDROXYPYRIDINE 3-Hydroxypyridine 1-BENZYL-3-[(2,6-DICHLOROBENZYL)OXY]-2-METHYL-4(1H)-PYRIDINONE 1-(2-CHLORO-6-FLUOROBENZYL)-3-[(2,6-DICHLOROBENZYL)OXY]-2-METHYL-4(1H)-PYRIDINONE
3-[(2-CHLORO-6-FLUOROBENZYL)OXY]-1-(4-FLUOROBENZYL)-2-METHYL-4(1H)-PYRIDINONE 3-[(2-CHLORO-6-FLUOROBENZYL)OXY]-2-METHYL-1-(4-NITROBENZYL)-4(1H)-PYRIDINONE 1-(2-CHLORO-6-FLUOROBENZYL)-3-[(2-CHLORO-6-FLUOROBENZYL)OXY]-2-METHYL-4(1H)-PYRIDINONE 1-[3-CHLORO-5-(TRIFLUOROMETHYL)-2-PYRIDINYL]-3-([3-CHLORO-5-(TRIFLUOROMETHYL)-2-PYRIDINYL]OXY)-2-METHYL-4(1H)-PYRIDINONE 3-[(2-CHLORO-6-FLUOROBENZYL)OXY]-2-METHYL-1-(4-METHYLBENZYL)-4(1H)-PYRIDINONE
3-[(2,6-DICHLOROBENZYL)OXY]-2-METHYL-1-(4-METHYLBENZYL)-4(1H)-PYRIDINONE 1-(3,4-DICHLOROBENZYL)-3-[(2,6-DICHLOROBENZYL)OXY]-2-METHYL-4(1H)-PYRIDINONE 3-(BENZYLOXY)-1-(2-CHLORO-6-FLUOROBENZYL)-2-METHYL-4(1H)-PYRIDINONE 3-[(4-CHLOROBENZYL)OXY]-1-[3-CHLORO-5-(TRIFLUOROMETHYL)-2-PYRIDINYL]-2-METHYL-4(1H)-PYRIDINONE 1-BENZYL-3-[(2-CHLORO-6-FLUOROBENZYL)OXY]-2-METHYL-4(1H)-PYRIDINONE
1-(4-CHLOROBENZYL)-3-[(2-CHLORO-6-FLUOROBENZYL)OXY]-2-METHYL-4(1H)-PYRIDINONE 3-[(2,6-DICHLOROBENZYL)OXY]-1-(4-FLUOROBENZYL)-2-METHYL-4(1H)-PYRIDINONE 3-[(2-CHLORO-6-FLUOROBENZYL)OXY]-2-METHYL-1-(3-NITRO-2-PYRIDINYL)-4(1H)-PYRIDINONE

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L1 DMHP DEFERIDONE DEFERIPRON DEFERIPRONE CP20 3-HYDROXY-1,2-DIMETHYL-4(1H)PYRIDINONE 3-HYDROXY-1,2-DIMETHYL-4(1H)-PYRIDONE TIMTEC-BB SBB006753 1,2-DIMETHYL-3-HYDROXY-4-PYRIDONE 1,2-DIMETHYL-3-HYDROXYPYRID-4-ONE 1,2-DIMETHYL-3-HYDROXYPYRIDIN-4-ONE 1,2-DIMETHYL-3-HYDROXYPYRIDINE-4-ONE 1,2-dimethyl-3-hydroxy-4(1h)-pyridinon 1,2-dimethyl-3-hydroxy-4(1h)-pyridinone 3-hydroxy-1,2-dimethyl-4(1h)-pyridon cp20(chelatingagent) 3-HYDROXY-1,2-DIMETHYL-4(1H)-PYRIDONE, 9 8% deferiprone(DFP) 1,2-Dimethyl-3-hydroxy-4-pyridone, 99+% Kelfer 1,2-DiMethyl-3-hydroxy-4-pyridone, 99+% 10GR 4(1H)-Pyridinone,3-hydroxy-1,2-diMethyl- 1,2-Dimethyl-3-hydroxy-1,4-dihydropyridine-4-one 3-Hydroxy-1,2-diMethylpyridin-4(1H)-one DEFERIPRONE PHARMACEUTICAL RAW MATERIALS 3-Hydroxy-1,2-dimethyl-1,4-dihydropyridin-4-one 3-Hydroxy-1,2-dimethyl-4(1H)-pyridone, 98.5% Deferiprone CRS 3-Hydroxy-1,2-dimethyl-4(1H)-pyridone> eferiprone Deferiprone ISO 9001：2015 REACH DeferiproneQ: What is Deferiprone Q: What is the CAS Number of Deferiprone Q: What is the storage condition of Deferiprone Q: What are the applications of Deferiprone 3-hydroxy-1,2-dimethylpyridin-4-one Debrisoquine Hemisulfate-13C 3-Hydroxy-1,2-dimethyl-4(1H)-pyridone, ≥ 98.0% Deferrone 30652-11-0 C7H9NO2 ALCOHOL Building Blocks Heterocyclic Building Blocks Piperidones Heterocycles API intermediates Chelating Agents, Ligands Chelating Agents & Ligands Intermediates & Fine Chemicals Pharmaceuticals Building Blocks Heterocyclic Building Blocks Piperidones