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GSK-3326595

GSK-3326595 structure

CAS No.: 1616392-22-3

Chemical Name:: GSK-3326595

Synonyms: GSK3326595;6-[(1-acetylpiperidin-4-yl)amino]-N-[(2S)-2-hydroxy-3-(1,2,3,4-tetrahydroisoquinolin-2-yl)propyl]pyrimidine-4-carboxamide;EPZ-015938;GSK-3326595,EPZ-015938;EPZ-015938 (GSK3326595);EPZ015938(pemrametostat);Pemrametostat (GSK3326595);EPZ015938; EPZ 015938; EPZ-015938;Pemrametostat, GSK3326595, EPZ015938;6-[(1-acetylpiperidin-4-yl)amino]-N-[(2S)-2-hydroxy-3-(1

CBNumber:: CB03121890

Molecular Formula:: C24H32N6O3

Molecular Weight:: 452.55

MDL Number:: MFCD29991177

MOL File:: 1616392-22-3.mol

Last updated:2024-11-19 23:02:33

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GSK-3326595 Properties

Boiling point	760.3±60.0 °C(Predicted)
Density	1.275±0.06 g/cm3(Predicted)
storage temp.	under inert gas (nitrogen or Argon) at 2–8 °C
solubility	Soluble in DMSO (up to 20 mg/ml).
pka	12.44±0.46(Predicted)
form	solid
color	Off-white
Stability	Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20° for up to 1 month.
FDA UNII	VXT8SZ6875

SAFETY

Risk and Safety Statements

Symbol(GHS)

GHS07

Signal word

Warning

Hazard statements

H302-H315-H319-H335

Precautionary statements

P261-P264-P270-P271-P280-P301+P312-P330-P302+P352-P321-P304+P340-P305+P351+P338-P332+P313-P362+P364-P337+P313-P403+P233-P405-P501

NFPA 704

	0
2		0

GSK-3326595 price More Price(26)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
Cayman Chemical	27305	GSK3326595	1616392-22-3	5mg	$116	2024-03-01	Buy
Cayman Chemical	27305	GSK3326595	1616392-22-3	25mg	$343	2024-03-01	Buy
Cayman Chemical	27305	GSK3326595	1616392-22-3	1mg	$32	2024-03-01	Buy
Cayman Chemical	27305	GSK3326595	1616392-22-3	10mg	$199	2024-03-01	Buy
ChemScene	CS-6451	GSK3326595 99.55%	1616392-22-3	50mg	$250	2021-12-16	Buy

Product number	Packaging	Price	Buy
27305	5mg	$116	Buy
27305	25mg	$343	Buy
27305	1mg	$32	Buy
27305	10mg	$199	Buy
CS-6451	50mg	$250	Buy

GSK-3326595 Chemical Properties,Uses,Production

Description

GSK3326595 (1616395-22-3) is a potent (IC50?= 6.2nM), selective (>4000-fold over 20 other methyltransferases), SAM uncompetitive, peptide competitive inhibitor of PRMT5.1?PRMT5 inhibition activated the p53 pathway?via?induction of alternative splicing of MDM4 leading to a potent anti-proliferative response both?in vitro?and?in vivo. Combination therapy with palbociclib (CDK4/6 inhibitor, Focus Cat.# 10-4760) and GSK3326595 lead to increased efficacy of palbociclib in treating native and resistant models of melanoma via regulation of the PRMT5-MDM4 axis.2?Currently in clinical trials.3

Uses

GSK-3326595 is a protein arginine methyltransferase 5(PRMT5) inhibitor under clinical trial.

References

1) Gerhart?et al.?(2018),?Activation of the p53-MDM4 regulatory axis defines the anti-tumor response to PRMT5 inhibition through its role in regulating cellular splicing; Sci. Rep.?8?9711 2) AbuHammad?et al.?(2019),?Regulation of PRMT5-MDM4 axis is critical in the response to CDK4/6 inhibitors in melanoma; Proc. Natl. Acad. Sci. USA?116?179909 3) NCT02783300

GSK-3326595 Preparation Products And Raw materials

Raw materials

Preparation Products

GSK-3326595 Suppliers

Global( 93)Suppliers

Supplier	Tel	Email	Country	ProdList	Advantage
ATK CHEMICAL COMPANY LIMITED	+undefined-21-51877795	ivan@atkchemical.com	China	32957	60
BOC Sciences	+1-631-485-4226	inquiry@bocsci.com	United States	19553	58
TargetMol Chemicals Inc.	+1-781-999-5354 +1-00000000000	marketing@targetmol.com	United States	32165	58
Career Henan Chemica Co	+86-0371-86658258 +8613203830695	laboratory@coreychem.com	China	30240	58
HANGZHOU CLAP TECHNOLOGY CO.,LTD	86-571-88216897,88216896 13588875226	sales@hzclap.com	CHINA	6312	58
InvivoChem	+1-708-310-1919 +1-13798911105	sales@invivochem.cn	United States	6391	58
TargetMol Chemicals Inc.		support@targetmol.com	United States	38632	58
Chemtour Biotech Co., Ltd	+8617327281506	market@chemtour.com	China	1460	58
Wuhan Topule Biopharmaceutical Co., Ltd	+8618327326525	masar@topule.com	China	8467	58
Aladdin Scientific	+1-+1(833)-552-7181	sales@aladdinsci.com	United States	57505	58

Supplier	Advantage
ATK CHEMICAL COMPANY LIMITED	60
BOC Sciences	58
TargetMol Chemicals Inc.	58
Career Henan Chemica Co	58
HANGZHOU CLAP TECHNOLOGY CO.,LTD	58
InvivoChem	58
TargetMol Chemicals Inc.	58
Chemtour Biotech Co., Ltd	58
Wuhan Topule Biopharmaceutical Co., Ltd	58
Aladdin Scientific	58

View Lastest Price from GSK-3326595 manufacturers

Image	Update time	Product	Price	Min. Order	Purity	Supply Ability	Manufacturer
	2024-11-19	GSK3326595 1616392-22-3	US $39.00-109.00 / mg		97.7%	10g	TargetMol Chemicals Inc.

GSK3326595
1616392-22-3
US $39.00-109.00 / mg
97.7%
TargetMol Chemicals Inc.

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EPZ-015938 4-Pyrimidinecarboxamide, 6-[(1-acetyl-4-piperidinyl)amino]-N-[(2S)-3-(3,4-dihydro-2(1H)-isoquinolinyl)-2-hydroxypropyl]- GSK-3326595,EPZ-015938 EPZ-015938 (GSK3326595) 4-tetrahydroisoquinolin-2-yl)propyl]pyrimidine-4-carboxamid 6-[(1-acetylpiperidin-4-yl)amino]-N-[(2S)-2-hydroxy-3-(1 EPZ015938; 6-[(1-ACETYLPIPERIDIN-4-YL)AMINO]-N-[(2S)-2-HYDROXY-3-(1;2;3;4-TETRAHYDROISOQUINOLIN-2-YL)PROPYL]PYRIMIDINE-4-CARBOXAMID EPZ015938; EPZ 015938; EPZ-015938 EPZ015938(pemrametostat) GSK3326595 6-[(1-acetylpiperidin-4-yl)amino]-N-[(2S)-2-hydroxy-3-(1,2,3,4-tetrahydroisoquinolin-2-yl)propyl]pyrimidine-4-carboxamide 6-[(1-acetyl-4-piperidyl)amino]-N-[(2S)-3-(3,4-dihydro-1H-isoquinolin-2-yl)-2-hydroxy-propyl]pyrimidine-4-carboxamide Pemrametostat, GSK3326595, EPZ015938 Pemrametostat (GSK3326595) 1616392-22-3 API