Conivaptan impurity
- CAS No.
- 1129433-63-1
- Chemical Name:
- Conivaptan impurity
- Synonyms
- Conivaptan-d4;N-[4-[(4,5-dihydro-2-methylimidazo[4,5-d][1]benzazepin-6(1H)-yl)carbonyl]phenyl-d4]-[1,1'-biphenyl]-2-carboxamide
- CBNumber:
- CB03144862
- Molecular Formula:
- C32H26N4O2
- Molecular Weight:
- 498.59
- MDL Number:
- MOL File:
- 1129433-63-1.mol
Conivaptan impurity price More Price(3)
Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
---|---|---|---|---|---|---|---|
Cayman Chemical | 26455 | Conivaptan-d4 | 1129433-63-1 | 500μg | $194 | 2024-03-01 | Buy |
Cayman Chemical | 26455 | Conivaptan-d4 | 1129433-63-1 | 1mg | $369 | 2024-03-01 | Buy |
AK Scientific | 3226DC | 2-Phenyl-N-[2,3,5,6-tetradeuterio-4-(2-methyl-4,5-dihydro-3H-imidazo[4,5-d][1]benzazepine-6-carbonyl)phenyl]benzamide | 1129433-63-1 | 1mg | $753 | 2021-12-16 | Buy |
Conivaptan impurity Chemical Properties,Uses,Production
Biological Activity
Conivaptan-d4 is intended for use as an internal standard for the quantification of conivaptan by GC- or LC-MS. Conivaptan is an antagonist of the arginine vasopressin (AVP) receptors V1A and V2 (Kis = 0.48 and 3.04 nM for rat liver V1A and kidney V2, respectively).1 It also competitively inhibits oxytocin binding to rat uterine oxytocin receptors (Ki = 44 nM) but has no effect on AVP binding to anterior pituitary V1B receptors at concentrations up to 100 μM in a radioligand binding assay. Conivaptan suppresses AVP-induced increases in intracellular calcium in vascular smooth muscle cells (VSMCs) in vitro and the pressor response in pithed rats. Conivaptan (0.01-0.3 mg/kg, i.v.) increases urine output and decreases urine osmolality in dehydrated conscious rats in a dose-dependent manner. It also reduces brain edema and blood-brain barrier disruption in a mouse experimental stroke model.2
References
1.Tahara, A., Tomura, Y., Wada, K.-I., et al.Pharmacological profile of YM087, a novel potent nonpeptide vasopressin V1A and V2 receptor antagonist, in vitro and in vivoJ. Pharmacol. Exp. Ther.282(1)301-308(1997) 2.Zeynalov, E., Jones, S.M., Seo, J.W., et al.Arginine-vasopressin receptor blocker conivaptan reduces brain edema and blood-brain barrier disruption after experimental stroke in micePLoS One10(8)e0136121(2015)
Conivaptan impurity Preparation Products And Raw materials
Raw materials
Preparation Products
Conivaptan impurity Suppliers
Supplier | Tel | Country | ProdList | Advantage | |
---|---|---|---|---|---|
Pharmacodia (Beijing) Co.,Ltd | +86-400-851-9921 | sales@pharmacodia.com | China | 2317 | 55 |
SHENZHEN PHYSTANDARD BIO-TECH CO.,LTD | 0755-0755-0755-83725350 13380397412 | 3001280422@qq.com | China | 10071 | 58 |
Shanghai isotope chemical co.,ltd | 021-021-51600108 13062666369 | sales@chinaisotope.com | China | 4274 | 58 |
Shanghai Yifei Biotechnology Co. , Ltd. | 021-65675885 18964387627 | customer_service@efebio.com | China | 8739 | 58 |
Hubei Moco Chemical Co., Ltd. | 18576690171 | 3001025734@qq.com | China | 10974 | 58 |