4-[(Biphenyl-2-ylcarbonyl)amino]benzoic acid
- CAS No.
- 168626-74-2
- Chemical Name:
- 4-[(Biphenyl-2-ylcarbonyl)amino]benzoic acid
- Synonyms
- Conivaptan-4;Conivaptan impurity D;Conivaptan Impurity 1;Conivaptan intermediate;4-(2-Phenylbenzamido)benzoic acid;Conivaptan hydrochloride Impurity D;4-[(2-phenylbenzoyl)amino]benzoic acid;4-[(2-Biphenylcarbonyl)amino]benzoic acid;4-[(biphenyl-2-carbonyl)amino]benzoic acid;4-[(Biphenyl-2-ylcarbonyl)amino]benzoic acid
- CBNumber:
- CB72510027
- Molecular Formula:
- C20H15NO3
- Molecular Weight:
- 317.34
- MDL Number:
- MFCD16038728
- MOL File:
- 168626-74-2.mol
Melting point | 246-248℃ |
---|---|
Boiling point | 474.5±38.0 °C(Predicted) |
Density | 1.29 |
pka | 4.26±0.10(Predicted) |
InChI | InChI=1S/C20H15NO3/c22-19(21-16-12-10-15(11-13-16)20(23)24)18-9-5-4-8-17(18)14-6-2-1-3-7-14/h1-13H,(H,21,22)(H,23,24) |
InChIKey | VIWLAZSPFNNYTJ-UHFFFAOYSA-N |
SMILES | C(O)(=O)C1=CC=C(NC(C2=CC=CC=C2C2=CC=CC=C2)=O)C=C1 |
FDA UNII | 26Q5WF9UVC |
4-[(Biphenyl-2-ylcarbonyl)amino]benzoic acid price More Price(9)
Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
---|---|---|---|---|---|---|---|
Matrix Scientific | 060040 | 4-([1,1'-Biphenyl]-2-ylcarboxamido)benzoic acid 90% | 168626-74-2 | 5g | $683 | 2021-12-16 | Buy |
AK Scientific | 5422AD | 4-([1,1'-Biphenyl]-2-ylcarboxamido)benzoicacid | 168626-74-2 | 5g | $972 | 2021-12-16 | Buy |
American Custom Chemicals Corporation | CHM0077932 | 4-[(BIPHENYL-2-CARBONYL)AMINO]BENZOIC ACID 95.00% | 168626-74-2 | 5G | $1501.5 | 2021-12-16 | Buy |
Crysdot | CD12134821 | 4-([1,1'-Biphenyl]-2-ylcarboxamido)benzoicacid 95+% | 168626-74-2 | 1g | $50 | 2021-12-16 | Buy |
Crysdot | CD12134821 | 4-([1,1'-Biphenyl]-2-ylcarboxamido)benzoicacid 95+% | 168626-74-2 | 5g | $150 | 2021-12-16 | Buy |
4-[(Biphenyl-2-ylcarbonyl)amino]benzoic acid Chemical Properties,Uses,Production
Synthesis
Thionyl chloride (10.4 g, 87.4 mmol) was added to a mixture of biphenyl-2-carboxylic acid (15.0 g, 75.7 mmol) and DMF (0.28 g, 3.83 mmol) in toluene (72 mL) at an internal temperature of 40 ºC. The mixture was stirred at this temperature for approximately 2 h. After completion of the reaction, the mixture was concentrated to dryness at 60 ºC. The resultant residue was then diluted with toluene (36 mL) and concentrated to dryness at 60 ºC, and the process was repeated again to give biphenyl-2- carbonyl chloride as an oil. Acetone (100 mL) was added to the oil, and 4-amino benzoic acid (10.4 g, 75.8 mmol) and N,N-dimethylaniline (10.1 g, 83.3 mmol) were added to the resultant solution at 25 ºC. The mixture was stirred at this temperature for approximately 2 h. Water (100 mL) was then poured into the mixture, and it was stirred at 25 ºC for more than 1 h. The resultant crystals were collected by fifiltration and dissolved in DMF (100 mL) at 25 ºC. The solution was then fifiltered to remove insoluble materials, water (100 mL) was poured into the fifiltrate, and it was stirred at 25 ºC for approximately 2 h. The resultant crystals were collected by fifiltration and dried at 40 ºC to give the amide as white crystals (22.7 g, 95%).
Reference: Tsunoda, T.; Yamazaki, A.; Mase, T.; Sakamoto, S. Org. Process Res. Dev. 2005, 9, 593–598.
4-[(Biphenyl-2-ylcarbonyl)amino]benzoic acid Preparation Products And Raw materials
Raw materials
Preparation Products
Supplier | Tel | Country | ProdList | Advantage | |
---|---|---|---|---|---|
Hefei TianRui Pharmaceutical Chemical Co., Ltd. | +86-0551-68665055 +86-+86-18616906106 | sales@trywchem.com | China | 129 | 58 |
Henan Tianfu Chemical Co.,Ltd. | +86-0371-55170693 +86-19937530512 | info@tianfuchem.com | China | 21668 | 55 |
Shanghai Yingrui Biopharma Co., Ltd. | +86-21-33585366 - 03@ | sales03@shyrchem.com | CHINA | 738 | 60 |
ATK CHEMICAL COMPANY LIMITED | +undefined-21-51877795 | ivan@atkchemical.com | China | 32760 | 60 |
Jinan Shengqi pharmaceutical Co,Ltd | 86+18663751872 | christine@shengqipharm.com | CHINA | 491 | 58 |
Standardpharm Co. Ltd. | 86-714-3992388 | overseasales1@yongstandards.com | United States | 14336 | 58 |
CONIER CHEM AND PHARMA LIMITED | +8618523575427 | sales@conier.com | China | 49391 | 58 |
career henan chemical co | +86-0371-86658258 +8613203830695 | factory@coreychem.com | China | 29825 | 58 |
Neostar United (Changzhou) Industrial Co., Ltd. | +86-519-519-85557386 | marketing1@neostarunited.com | China | 11006 | 58 |
Hefei Hirisun Pharmatech Co., Ltd | +8615056975894 | shawn@hirisunpharm.com | CHINA | 9923 | 58 |
View Lastest Price from 4-[(Biphenyl-2-ylcarbonyl)amino]benzoic acid manufacturers
Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
---|---|---|---|---|---|---|---|---|
2020-01-09 | 4-[(Biphenyl-2-ylcarbonyl)amino]benzoic acid
168626-74-2
|
US $9.80 / KG | 1g | ≥99% | 100kg | Career Henan Chemical Co |
- 4-[(Biphenyl-2-ylcarbonyl)amino]benzoic acid
168626-74-2
- US $9.80 / KG
- ≥99%
- Career Henan Chemical Co
168626-74-2(4-[(Biphenyl-2-ylcarbonyl)amino]benzoic acid)Related Search:
1of3