HLI 373 (hydrochloride)
- CAS No.
- 1782531-99-0
- Chemical Name:
- HLI 373 (hydrochloride)
- Synonyms
- HLI373 dihydrochloride;HLI 373 (hydrochloride)
- CBNumber:
- CB03152629
- Molecular Formula:
- C18H24ClN5O2
- Molecular Weight:
- 377.87
- MDL Number:
- MOL File:
- 1782531-99-0.mol
HLI 373 (hydrochloride) price More Price(4)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| TRC | H456348 | HLI373 | 1782531-99-0 | 5mg | $250 | 2021-12-16 | Buy |
| ChemScene | CS-0120642 | HLI373dihydrochloride | 1782531-99-0 | 5mg | $320 | 2021-12-16 | Buy |
| Axon Medchem | Axon1643 | HLI373 98% | 1782531-99-0 | 25mg | $335.5 | 2021-12-16 | Buy |
| ChemScene | CS-0120642 | HLI373dihydrochloride | 1782531-99-0 | 10mg | $540 | 2021-12-16 | Buy |
HLI 373 (hydrochloride) Chemical Properties,Uses,Production
Uses
HLI 373 is an apoptosis inducer and inhibitor of Hdm2 ubiquitin ligase.
Uses
HLI 373 (hydrochloride) is a ubiquitin ligase and key negative regulator of p53, targeting it for proteasomal degradation. Overexpression of HLI 373 (hydrochloride) in some tumors leads to inactivation of p53, thereby allowing tumor cells to escape p53-induced apoptosis. HLI 373 (hydrochloride) is an inhibitor of Hdm-2. At concentrations of 5-50 μM, it selectively inhibits autoubiquitylation of Hdm-2 as well as the ubiquitylation and degradation of p53. Through these actions, HLI 373 (hydrochloride) stabilizes p53 and increases p53-dependent transcription, inducing apoptosis of transformed cells, tumor cells, and mouse embryo fibroblasts harboring wild-type p53.[Cayman Chemical]
Definition
ChEBI: 5-[3-(dimethylamino)propylamino]-3,10-dimethylpyrimido[4,5-b]quinoline-2,4-dione is an aminoquinoline.
storage
Desiccate at RT
HLI 373 (hydrochloride) Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Aladdin Scientific | +1-+1(833)-552-7181 | sales@aladdinsci.com | United States | 52927 | 58 |
| Shanghai EFE Biological Technology Co., Ltd. | 021-65675885 18964387627 | info@efebio.com | China | 9707 | 58 |
| Shanghai Yiyan Biotechnology Co. , Ltd. | 021-69985186 13611928337 | 3427709316@qq.com | China | 7980 | 58 |
| Nantong QuanYi Biotechnology Co., Ltd | 0513-66337626 18051384581 | sales@chemhifuture.com | China | 4608 | 58 |
| TargetMol Chemicals Inc. | 15002134094 | marketing@targetmol.cn | China | 28091 | 58 |