HLI 373 (hydrochloride)
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HLI 373 (hydrochloride) 속성
- 저장 조건
- Store at -20°C
- 용해도
- Soluble to 100 mM in water and to 10 mM in DMSO
- 물리적 상태
- Solid
- 색상
- Light yellow to yellow
안전
HLI 373 (hydrochloride) C화학적 특성, 용도, 생산
용도
HLI 373 (hydrochloride) is a ubiquitin ligase and key negative regulator of p53, targeting it for proteasomal degradation. Overexpression of HLI 373 (hydrochloride) in some tumors leads to inactivation of p53, thereby allowing tumor cells to escape p53-induced apoptosis. HLI 373 (hydrochloride) is an inhibitor of Hdm-2. At concentrations of 5-50 μM, it selectively inhibits autoubiquitylation of Hdm-2 as well as the ubiquitylation and degradation of p53. Through these actions, HLI 373 (hydrochloride) stabilizes p53 and increases p53-dependent transcription, inducing apoptosis of transformed cells, tumor cells, and mouse embryo fibroblasts harboring wild-type p53.[Cayman Chemical]HLI 373 (hydrochloride) 준비 용품 및 원자재
원자재
준비 용품
HLI 373 (hydrochloride) 공급 업체
글로벌( 16)공급 업체
| 공급자 | 전화 | 이메일 | 국가 | 제품 수 | 이점 |
|---|---|---|---|---|---|
| Aladdin Scientific | +1-+1(833)-552-7181 |
sales@aladdinsci.com | United States | 52927 | 58 |
| Shanghai EFE Biological Technology Co., Ltd. | 021-65675885 18964387627 |
info@efebio.com | China | 9707 | 58 |
| Shanghai Yiyan Biotechnology Co. , Ltd. | 021-69985186 13611928337 |
3427709316@qq.com | China | 7980 | 58 |
| Nantong QuanYi Biotechnology Co., Ltd | 0513-66337626 18051384581 |
sales@chemhifuture.com | China | 4578 | 58 |
| TargetMol Chemicals Inc. | 15002134094 |
marketing@targetmol.cn | China | 28091 | 58 |