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CAY10535 Exclusive

CAY10535 Exclusive Structure
CAY10535 Exclusive structure
CAS No.
945716-28-9
Chemical Name:
CAY10535 Exclusive
Synonyms
CAY10535,CAY-10535;CAY10535 Exclusive;1-tert-butyl-3-[2-(3-methoxyphenoxy)-5-nitrophenyl]sulfonylurea;Benzenesulfonamide, N-[[(1,1-dimethylethyl)amino]carbonyl]-2-(3-methoxyphenoxy)-5-nitro-
CBNumber:
CB03152937
Molecular Formula:
C18H21N3O7S
Molecular Weight:
423.44
MDL Number:
MOL File:
945716-28-9.mol
Last updated:2023-05-21 10:59:17
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CAY10535 Exclusive Properties

storage temp. Store at -20°C
solubility DMF: 20 mg/ml; DMF:PBS (pH 7.2) (1:3): 0.25 mg/ml; DMSO: 20 mg/ml; Ethanol: 10 mg/ml
form A crystalline solid

CAY10535 Exclusive price More Price(9)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Cayman Chemical 10010396 CAY10535 ≥98% 945716-28-9 1mg $36 2024-03-01 Buy
Cayman Chemical 10010396 CAY10535 ≥98% 945716-28-9 5mg $162 2024-03-01 Buy
Cayman Chemical 10010396 CAY10535 ≥98% 945716-28-9 10mg $286 2024-03-01 Buy
Cayman Chemical 10010396 CAY10535 ≥98% 945716-28-9 50mg $1498 2023-06-20 Buy
AK Scientific 9421CW 1-Tert-butyl-3-[2-(3-methoxyphenoxy)-5-nitrophenyl]sulfonylurea 945716-28-9 50mg $1801 2021-12-16 Buy
Product number Packaging Price Buy
10010396 1mg $36 Buy
10010396 5mg $162 Buy
10010396 10mg $286 Buy
10010396 50mg $1498 Buy
9421CW 50mg $1801 Buy

CAY10535 Exclusive Chemical Properties,Uses,Production

Description

TPα and TPβ are two isoforms of the human TP receptor, the G protein-coupled receptor (GPCR) that mediates the actions of thromboxane A2 (TXA2). Although their distinct physiological functions have not been fully elucidated, TPβ is believed to be responsible for vascular endothelial growth factor-induced endothelial cell differentiation and migration whereas TPα appears to be the predominant isoform expressed in platelets. CAY10535 is a TP receptor antagonist that shows ~20-fold selectivity for TPβ (IC50 = 99 nM) relative to TPα (IC50 = 1,970 nM) in the inhibition of U46619-mediated Ca2+ mobilization. This compound exhibits relatively poor activity on platelets (IC50 = 985 nM) when inhibiting U-46619-induced platelet aggregation.1

References

1. Hanson, J., Dogné, J.M., Ghiotto, J., et al. Design, synthesis, and SAR study of a series of N-alkyl-N'-[2-(aryloxy)-5-nitrobenzenesulfonyl]ureas and -cyanoguanidine as selective antagonists of the TPα and TPβ isoforms of the human thromboxane A2 receptor J. Med. Chem. 50(16),3928-3936(2007).

CAY10535 Exclusive Preparation Products And Raw materials

Raw materials

Preparation Products

CAY10535 Exclusive Suppliers

Global( 7)Suppliers
Supplier Tel Email Country ProdList Advantage
BOC Sciences 16314854226 info@bocsci.com United States 9926 65
Shanghai Hongye Biotechnology Co. Ltd 400-9205774 sales@glpbio.cn China 6870 58
ChemeGen(Shanghai) Biotechnology Co.,Ltd. 18818260767 sales@chemegen.com China 11289 58
TargetMol Chemicals Inc. 4008200310 marketing@tsbiochem.com China 24017 58
Shanghai Yifei Biotechnology Co. , Ltd. 021-65675885 18964387627 customer_service@efebio.com China 8740 58
Supplier Advantage
BOC Sciences 65
Shanghai Hongye Biotechnology Co. Ltd 58
ChemeGen(Shanghai) Biotechnology Co.,Ltd. 58
TargetMol Chemicals Inc. 58
Shanghai Yifei Biotechnology Co. , Ltd. 58
CAY10535 Exclusive 1-tert-butyl-3-[2-(3-methoxyphenoxy)-5-nitrophenyl]sulfonylurea Benzenesulfonamide, N-[[(1,1-dimethylethyl)amino]carbonyl]-2-(3-methoxyphenoxy)-5-nitro- CAY10535,CAY-10535 945716-28-9